PMID- 30074603
OWN - NLM
STAT- MEDLINE
DCOM- 20190808
LR  - 20190808
IS  - 1460-4752 (Electronic)
IS  - 0265-0568 (Linking)
VI  - 36
IP  - 2
DP  - 2019 Feb 20
TI  - Native roles of Baeyer-Villiger monooxygenases in the microbial metabolism of 
      natural compounds.
PG  - 326-353
LID - 10.1039/c8np00054a [doi]
AB  - Covering: up to end of June 2018 Baeyer-Villiger monooxygenases (BVMOs) are 
      flavin-dependent enzymes that catalyse the oxidation of ketones and cyclic 
      ketones to esters and lactones, respectively, by using molecular oxygen and 
      NAD(P)H. BVMOs also catalyse sulfoxidations and N-oxidations. BVMOs are widely 
      studied as attractive biocatalysts, but also catalyse key reactions in metabolic 
      pathways of the organisms from which they are sourced. BVMOs are involved in the 
      primary metabolism of atypical carbon sources, thereby conferring an evolutionary 
      advantage to the host organism. In addition, BVMOs catalyse a plethora of diverse 
      Baeyer-Villiger and heteroatom oxidations in the construction of complex 
      secondary metabolites. These natural products often have attractive biological 
      properties, such as anti-bacterial, anti-cancer and anti-proliferative activity, 
      and can have clinical applications. In contrast, BVMOs are also involved in the 
      synthesis of microbial toxins. This review will discuss the inherent roles of 
      type I, type II and type O BVMOs in the metabolism of microorganisms.
FAU - Tolmie, Carmien
AU  - Tolmie C
AD  - Department of Biotechnology, University of the Free State, Bloemfontein, South 
      Africa. tolmiec@ufs.ac.za smitms@ufs.ac.za opperdj@ufs.ac.za.
FAU - Smit, Martha S
AU  - Smit MS
FAU - Opperman, Diederik J
AU  - Opperman DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Prod Rep
JT  - Natural product reports
JID - 8502408
RN  - 0 (Alcohols)
RN  - 0 (Alkanes)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Biological Products)
RN  - 0 (Dinitrocresols)
RN  - 0 (Ketones)
RN  - 0 (Mycotoxins)
RN  - 0 (Xenobiotics)
RN  - 1604ZJR09T (4,6-dinitro-o-cresol)
RN  - EC 1.- (Mixed Function Oxygenases)
MH  - Alcohols/chemistry/metabolism
MH  - Alkanes/metabolism
MH  - Anti-Bacterial Agents/chemistry/metabolism
MH  - Bacteria/*metabolism
MH  - Biological Products/*metabolism
MH  - Dinitrocresols/metabolism
MH  - Fungi/metabolism
MH  - Ketones/metabolism
MH  - Mixed Function Oxygenases/*chemistry/*metabolism
MH  - Mycotoxins/*metabolism
MH  - Oxidation-Reduction
MH  - Secondary Metabolism
MH  - Xenobiotics/metabolism
EDAT- 2018/08/04 06:00
MHDA- 2019/08/09 06:00
CRDT- 2018/08/04 06:00
PHST- 2018/08/04 06:00 [pubmed]
PHST- 2019/08/09 06:00 [medline]
PHST- 2018/08/04 06:00 [entrez]
AID - 10.1039/c8np00054a [doi]
PST - ppublish
SO  - Nat Prod Rep. 2019 Feb 20;36(2):326-353. doi: 10.1039/c8np00054a.