PMID- 30075432
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 63
DP  - 2018 Oct
TI  - The impact of metabolic reprogramming on dendritic cell function.
PG  - 84-93
LID - S1567-5769(18)30360-6 [pii]
LID - 10.1016/j.intimp.2018.07.031 [doi]
AB  - Dendritic cells (DCs) are antigen-presenting cells with the ability to activate 
      naive T cells and direct the adaptive cellular immune response toward a specific 
      profile. This is important, as different pathogens demand specific "profiles" of 
      immune responses for their elimination. Such a goal is achieved depending on the 
      maturation/activation status of DCs by the time of antigen presentation to T 
      cells. Notwithstanding this, recent studies have shown that DCs alter their 
      metabolic program to accommodate the functional changes in gene expression and 
      protein synthesis that follow antigen recognition. In this review, we aim to 
      summarize the data in the literature regarding the metabolic pathways involved 
      with DC phenotypes and their functions.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - de Lima Thomaz, Livia
AU  - de Lima Thomaz L
AD  - Department of Structural and Functional Biology, Institute of Biology, University 
      of Campinas, UNICAMP, Campinas, SP, Brazil.
FAU - Peron, Gabriela
AU  - Peron G
AD  - Department of Structural and Functional Biology, Institute of Biology, University 
      of Campinas, UNICAMP, Campinas, SP, Brazil.
FAU - Oliveira, Janine
AU  - Oliveira J
AD  - Department of Structural and Functional Biology, Institute of Biology, University 
      of Campinas, UNICAMP, Campinas, SP, Brazil.
FAU - da Rosa, Larissa Camargo
AU  - da Rosa LC
AD  - Department of Structural and Functional Biology, Institute of Biology, University 
      of Campinas, UNICAMP, Campinas, SP, Brazil. Electronic address: 
      darosalc@gmail.com.
FAU - Thome, Rodolfo
AU  - Thome R
AD  - Department of Neurology, Thomas Jefferson University, Philadelphia, USA.
FAU - Verinaud, Liana
AU  - Verinaud L
AD  - Department of Structural and Functional Biology, Institute of Biology, University 
      of Campinas, UNICAMP, Campinas, SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180801
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
SB  - IM
MH  - Animals
MH  - Dendritic Cells/immunology/*metabolism
MH  - Humans
MH  - Signal Transduction
OTO - NOTNLM
OT  - Autophagy
OT  - Dendritic cells
OT  - Fatty Acid
OT  - Glucose
OT  - Metabolism
OT  - mTOR
EDAT- 2018/08/04 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/08/04 06:00
PHST- 2018/05/21 00:00 [received]
PHST- 2018/07/24 00:00 [revised]
PHST- 2018/07/25 00:00 [accepted]
PHST- 2018/08/04 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/08/04 06:00 [entrez]
AID - S1567-5769(18)30360-6 [pii]
AID - 10.1016/j.intimp.2018.07.031 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2018 Oct;63:84-93. doi: 10.1016/j.intimp.2018.07.031. Epub 
      2018 Aug 1.