PMID- 30076416
OWN - NLM
STAT- MEDLINE
DCOM- 20191016
LR  - 20240329
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Aug 3
TI  - Biological and epidemiological evidence of anti-allergic effects of traditional 
      Japanese food ume (Prunus mume).
PG  - 11638
LID - 10.1038/s41598-018-30086-5 [doi]
LID - 11638
AB  - Japanese apricot (Prunus mume; ume) is a traditional food in Japan that has been 
      shown to have various beneficial health effects. There is some evidence to 
      suggest that ume is also effective against allergic disease. Here, we conducted a 
      cross-sectional epidemiological pilot study to examine the association between 
      ume intake frequency and allergic symptoms including rhinitis in 563 adults (288 
      men and 275 women) who resided in Wakayama, Japan. After adjusting for age, 
      present illness and medication, women with high ume intake had significantly 
      lower odds ratio (OR) for the presence of symptoms of allergy [OR: 0.49 with 95% 
      confidence interval (CI): 0.25-0.97]. Therefore, we investigated the 
      anti-allergic effect of ume on passive cutaneous anaphylaxis (PCA) reaction in 
      immunoglobulin E (IgE)-sensitized mice. The animal study demonstrated that oral 
      administration of ume extract attenuated the PCA reaction and mast cell 
      degranulation. Furthermore, RBL-2H3 mast cells were used to identify 
      anti-allergic ume compounds. The following ume compounds inhibited IgE-mediated 
      mast cell degranulation: vanillin, syringic acid, protocatechuic aldehyde, 
      lyoniresinol and p-coumaric acid. These results suggested that ume has the 
      potential to inhibit mast cell degranulation and may be associated with reduced 
      risk of allergic symptoms in women.
FAU - Kono, Ryohei
AU  - Kono R
AD  - Department of Strategic Surveillance for Functional Food and Comprehensive 
      Traditional Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 
      City, Wakayama, 641-0012, Japan.
FAU - Nakamura, Misa
AU  - Nakamura M
AD  - Department of Rehabilitation, Osaka Kawasaki Rehabilitation University, 158 
      Mizuma, Kaizuka City, Osaka, 597-0104, Japan.
FAU - Nomura, Sachiko
AU  - Nomura S
AD  - Department of Strategic Surveillance for Functional Food and Comprehensive 
      Traditional Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 
      City, Wakayama, 641-0012, Japan.
FAU - Kitano, Naomi
AU  - Kitano N
AUID- ORCID: 0000-0001-6103-4907
AD  - Research Center for Community Medicine, Wakayama Medical University, 811-1 
      Kimiidera, Wakayama City, Wakayama, 641-0012, Japan.
AD  - Department of Public Health, School of Medicine, Wakayama Medical University, 
      811-1 Kimiidera, Wakayama City, Wakayama, 641-0012, Japan.
FAU - Kagiya, Tomoko
AU  - Kagiya T
AD  - Faculty of Health Science, Kansai University of Health Science, 2-11-1 Wakaba, 
      Kumatori-cho, Sennan-gun, Osaka, 590-0482, Japan.
FAU - Okuno, Yoshiharu
AU  - Okuno Y
AUID- ORCID: 0000-0003-4422-9547
AD  - Department of Applied Chemistry and Biochemistry, National Institute of 
      Technology, Wakayama Collage, 77 Noshima, Nada, Gobo, Wakayama, 644-0023, Japan.
FAU - Inada, Ken-Ichi
AU  - Inada KI
AD  - Department of Pathology, Fujita Health University School of Medicine, 1-98 
      Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
FAU - Tokuda, Akihiko
AU  - Tokuda A
AD  - Department of Strategic Surveillance for Functional Food and Comprehensive 
      Traditional Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 
      City, Wakayama, 641-0012, Japan.
FAU - Utsunomiya, Hirotoshi
AU  - Utsunomiya H
AD  - Department of Strategic Surveillance for Functional Food and Comprehensive 
      Traditional Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 
      City, Wakayama, 641-0012, Japan. utsu@wakayama-med.ac.jp.
FAU - Ueno, Masami
AU  - Ueno M
AD  - Research Center for Community Medicine, Wakayama Medical University, 811-1 
      Kimiidera, Wakayama City, Wakayama, 641-0012, Japan.
LA  - eng
GR  - JP25870636/Japan Society for the Promotion of Science (JSPS)/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180803
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Anti-Allergic Agents/*administration & dosage/chemistry
MH  - Female
MH  - Food
MH  - Humans
MH  - Immunoglobulin E/administration & dosage/immunology
MH  - Japan/epidemiology
MH  - Male
MH  - Mast Cells/drug effects
MH  - Mice
MH  - Middle Aged
MH  - Passive Cutaneous Anaphylaxis/*drug effects
MH  - Plant Extracts/administration & dosage/chemistry
MH  - Prunus/*chemistry
MH  - Rhinitis, Allergic/*diet therapy/epidemiology/immunology/pathology
PMC - PMC6076304
COIS- The authors declare no competing interests.
EDAT- 2018/08/05 06:00
MHDA- 2019/10/17 06:00
PMCR- 2018/08/03
CRDT- 2018/08/05 06:00
PHST- 2017/08/29 00:00 [received]
PHST- 2018/07/24 00:00 [accepted]
PHST- 2018/08/05 06:00 [entrez]
PHST- 2018/08/05 06:00 [pubmed]
PHST- 2019/10/17 06:00 [medline]
PHST- 2018/08/03 00:00 [pmc-release]
AID - 10.1038/s41598-018-30086-5 [pii]
AID - 30086 [pii]
AID - 10.1038/s41598-018-30086-5 [doi]
PST - epublish
SO  - Sci Rep. 2018 Aug 3;8(1):11638. doi: 10.1038/s41598-018-30086-5.