PMID- 30076998
OWN - NLM
STAT- MEDLINE
DCOM- 20190329
LR  - 20200930
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 388
DP  - 2018 Sep 15
TI  - BDNF and TrkB Mediate the Improvement from Chronic Stress-induced Spatial Memory 
      Deficits and CA3 Dendritic Retraction.
PG  - 330-346
LID - S0306-4522(18)30531-1 [pii]
LID - 10.1016/j.neuroscience.2018.07.049 [doi]
AB  - The brain is capable of improving from a chronically stressed state. The 
      hippocampus in particular appears to "recover" from chronic stress-induced 
      morphological and functional deficits following a post-stress rest period of 
      several weeks. We previously found that hippocampal brain-derived neurotrophic 
      factor (BDNF) was necessary for spatial ability to improve following a 
      post-stress rest period. The following studies are the first to investigate the 
      involvement of BDNF and its TrkB receptor on the recovery process following the 
      end of chronic stress, as it pertains to hippocampal dendritic retraction and 
      spatial memory deficits. In the first study, hippocampal BDNF was downregulated 
      via RNA interference and then hippocampal CA3 and CA1 dendritic complexity were 
      evaluated following chronic stress and a post-stress rest period in male 
      Sprague-Dawley rats. Downregulating hippocampal BDNF prevented the enhancement of 
      CA3 apical dendritic complexity following the rest period. Moreover, chronic 
      stress and downregulated BDNF in the post-stress rest group led to regionally 
      specific enhancements in CA1 dendritic complexity. In the second study, we tested 
      whether the TrkB receptor was involved by administering daily systemic injections 
      of ANA-12, a TrkB receptor antagonist, during the three-week post-stress rest 
      period. ANA-12 prevented the improvement in spatial ability and CA3 apical 
      dendritic complexity following the post-stress rest period. These data 
      demonstrate that hippocampal BDNF acting via its TrkB receptor is necessary 
      during the post-stress rest period in order to improve the impaired hippocampal 
      structural and cognitive outcomes that occur in response to chronic stress.
CI  - Copyright (c) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Ortiz, J Bryce
AU  - Ortiz JB
AD  - Department of Psychology, Arizona State University, Tempe, AZ 85287, USA.
FAU - Anglin, Julia M
AU  - Anglin JM
AD  - Department of Psychology, Arizona State University, Tempe, AZ 85287, USA.
FAU - Daas, Eshaan J
AU  - Daas EJ
AD  - Department of Psychology, Arizona State University, Tempe, AZ 85287, USA.
FAU - Paode, Pooja R
AU  - Paode PR
AD  - Department of Psychology, Arizona State University, Tempe, AZ 85287, USA.
FAU - Nishimura, Kenji
AU  - Nishimura K
AD  - Department of Psychology, Arizona State University, Tempe, AZ 85287, USA.
FAU - Conrad, Cheryl D
AU  - Conrad CD
AD  - Department of Psychology, Arizona State University, Tempe, AZ 85287, USA. 
      Electronic address: conradc@asu.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180802
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Ntrk2 protein, rat)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - CA1 Region, Hippocampal/metabolism/pathology
MH  - CA3 Region, Hippocampal/*metabolism/pathology
MH  - Chronic Disease
MH  - Dendrites/metabolism/pathology
MH  - Male
MH  - Memory Disorders/etiology/*metabolism/pathology
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/antagonists & inhibitors/*metabolism
MH  - Rest
MH  - Spatial Memory/*physiology
MH  - Stress, Psychological/*metabolism/pathology
OTO - NOTNLM
OT  - BDNF
OT  - TrkB
OT  - chronic stress
OT  - dendrites
OT  - hippocampus
OT  - spatial memory
EDAT- 2018/08/05 06:00
MHDA- 2019/03/30 06:00
CRDT- 2018/08/05 06:00
PHST- 2018/03/15 00:00 [received]
PHST- 2018/07/23 00:00 [revised]
PHST- 2018/07/25 00:00 [accepted]
PHST- 2018/08/05 06:00 [pubmed]
PHST- 2019/03/30 06:00 [medline]
PHST- 2018/08/05 06:00 [entrez]
AID - S0306-4522(18)30531-1 [pii]
AID - 10.1016/j.neuroscience.2018.07.049 [doi]
PST - ppublish
SO  - Neuroscience. 2018 Sep 15;388:330-346. doi: 10.1016/j.neuroscience.2018.07.049. 
      Epub 2018 Aug 2.