PMID- 30077618
OWN - NLM
STAT- MEDLINE
DCOM- 20190329
LR  - 20190329
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 388
DP  - 2018 Sep 15
TI  - Is Objectively Assessed Sedentary Behavior, Physical Activity and 
      Cardiorespiratory Fitness Linked to Brain Plasticity Outcomes in Old Age?
PG  - 384-392
LID - S0306-4522(18)30532-3 [pii]
LID - 10.1016/j.neuroscience.2018.07.050 [doi]
AB  - The aim of this cross-sectional study was to determine the associations of 
      objectively assessed habitual physical activity and physical performance with 
      brain plasticity outcomes and brain-derived neurotrophic factor (BDNF) levels in 
      cognitively healthy older adults. Physical performance was analyzed based on 
      cardiopulmonary exercise-testing data and accelerometer-based physical activity 
      was analyzed as total activity counts, sedentary time, light physical activity 
      and moderate to vigorous physical activity. Brain plasticity outcomes included 
      magnetic resonance spectroscopy (MRS)-based markers, quantitative imaging-based 
      hippocampal volume and BDNF serum levels. The association between physical 
      performance and hippocampal volume was strongly influenced by participants' 
      education, sex, age and BMI. Confounder-controlled correlation revealed 
      significant associations of brain plasticity outcomes with physical activity but 
      not with performance. MRS-based adenosine triphosphate to phosphocreatine and 
      glycerophosphocholine to phosphocreatine ratios were significantly associated 
      with accelerometer total activity counts. BDNF was detrimentally associated with 
      sedentary time but beneficially related to accelerometer total activity counts 
      and moderate to vigorous physical activity. Exceeding the current moderate to 
      vigorous physical activity recommendations led to significantly higher BDNF 
      levels. Our results indicate that regular physical activity might be beneficial 
      for preserving brain plasticity in higher age. In this study these associations 
      were not mediated significantly by physical performance. Overall physical 
      activity and exceeding current moderate to vigorous physical activity 
      recommendations were positively associated with BDNF. Sedentary behavior, 
      however, seems to be negatively related to neurotrophic factor bioavailability in 
      the elderly.
CI  - Copyright (c) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Engeroff, Tobias
AU  - Engeroff T
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt, Germany. Electronic address: Engeroff@sport.uni-frankfurt.de.
FAU - Fuzeki, Eszter
AU  - Fuzeki E
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt, Germany.
FAU - Vogt, Lutz
AU  - Vogt L
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt, Germany.
FAU - Fleckenstein, Johannes
AU  - Fleckenstein J
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt, Germany; Department of Sports Medicine and Exercise Physiology, 
      Institute of Sports Sciences, Justus-Liebig University, Giessen, Germany.
FAU - Schwarz, Sina
AU  - Schwarz S
AD  - Neurocognition and Action - Biomechanics Research Group, Faculty of Psychology 
      and Sport Science, Center of Excellence "Cognitive Interaction Technology", 
      Research Institute for Cognition and Robotics, Bielefeld University, Germany.
FAU - Matura, Silke
AU  - Matura S
AD  - Institute of General Practice, Goethe University, Frankfurt, Germany; Laboratory 
      of Neurophysiology and Neuroimaging, Department of Psychiatry, Psychosomatic 
      Medicine and Psychotherapy, Goethe University, Frankfurt/Main, Germany.
FAU - Pilatus, Ulrich
AU  - Pilatus U
AD  - Institute of Neuroradiology, Goethe University Hospital Frankfurt, Germany.
FAU - Deichmann, Ralf
AU  - Deichmann R
AD  - Brain Imaging Center, 60528 Frankfurt, Germany.
FAU - Hellweg, Rainer
AU  - Hellweg R
AD  - Neurobiology and Neurotophins Laboratory, Department of Psychiatry and 
      Psychotherapy, Charite University Medicine, Berlin, Germany.
FAU - Pantel, Johannes
AU  - Pantel J
AD  - Institute of General Practice, Goethe University, Frankfurt, Germany.
FAU - Banzer, Winfried
AU  - Banzer W
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt, Germany.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180803
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Accelerometry
MH  - Aged
MH  - Aging/*metabolism/pathology
MH  - Body Mass Index
MH  - Brain/diagnostic imaging/pathology/*physiology
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Cardiorespiratory Fitness/*physiology
MH  - Cross-Sectional Studies
MH  - Educational Status
MH  - Endurance Training
MH  - Exercise/*physiology
MH  - Female
MH  - Health Promotion
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Organ Size
MH  - *Sedentary Behavior
OTO - NOTNLM
OT  - aging
OT  - brain volume
OT  - cognitive decline
OT  - cognitive function
OT  - elderly
OT  - neuronal energy reserve
EDAT- 2018/08/06 06:00
MHDA- 2019/03/30 06:00
CRDT- 2018/08/06 06:00
PHST- 2018/03/23 00:00 [received]
PHST- 2018/06/13 00:00 [revised]
PHST- 2018/07/25 00:00 [accepted]
PHST- 2018/08/06 06:00 [pubmed]
PHST- 2019/03/30 06:00 [medline]
PHST- 2018/08/06 06:00 [entrez]
AID - S0306-4522(18)30532-3 [pii]
AID - 10.1016/j.neuroscience.2018.07.050 [doi]
PST - ppublish
SO  - Neuroscience. 2018 Sep 15;388:384-392. doi: 10.1016/j.neuroscience.2018.07.050. 
      Epub 2018 Aug 3.