PMID- 30077805
OWN - NLM
STAT- MEDLINE
DCOM- 20190827
LR  - 20221207
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 195
DP  - 2018 Oct
TI  - Formononetin attenuated allergic diseases through inhibition of 
      epithelial-derived cytokines by regulating E-cadherin.
PG  - 67-76
LID - S1521-6616(18)30059-7 [pii]
LID - 10.1016/j.clim.2018.07.018 [doi]
AB  - Radix Astragali, has long been used to alleviate allergic diseases (ADs). 
      Formononetin is one of the major active components in Radix Astragali, but its 
      mechanism on ADs is not definitively known. The fluorescein isothiocyanate 
      isomer-induced atopic contact dermatitis mouse model and poly I:C or 
      lipopolysaccharide-treated HaCaT cells were used to examine thymic stromal 
      lymphopoietin (TSLP)/interleukin (IL)-33 production and expression of E-cadherin. 
      After administration of formononetin, TSLP/IL-33 levels decreased both in vitro 
      and in vivo, while E-cadherin was increased in vivo and restored in vitro. 
      Furthermore, small interference RNA silencing of E-cadherin resulted in elevated 
      levels of TSLP, whereas the inhibitory effect of formononetin on TSLP was no 
      longer observed. In addition, TSLP resulted in no detectable changes in 
      delocalization or protein expression of E-cadherin in HaCaT cells. These results 
      indicated that formononetin showed a protective effect in ADs, which was 
      correlated with decreasing TSLP/IL-33 production via regulation of E-cadherin.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Li, Lianqu
AU  - Li L
AD  - Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia 
      Medica, Jiangsu Key Laboratory of Pediatric Respiratory Disease, Nanjing 
      University of Chinese Medicine, Nanjing 210023, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia 
      Medica, Jiangsu Key Laboratory of Pediatric Respiratory Disease, Nanjing 
      University of Chinese Medicine, Nanjing 210023, China.
FAU - Wang, Xiaoyu
AU  - Wang X
AD  - Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia 
      Medica, Jiangsu Key Laboratory of Pediatric Respiratory Disease, Nanjing 
      University of Chinese Medicine, Nanjing 210023, China.
FAU - Tao, Yu
AU  - Tao Y
AD  - Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia 
      Medica, Jiangsu Key Laboratory of Pediatric Respiratory Disease, Nanjing 
      University of Chinese Medicine, Nanjing 210023, China; Suzhou Hospital of 
      Traditional Chinese Medicine, Suzhou 215009, China.
FAU - Bao, Kaifan
AU  - Bao K
AD  - Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia 
      Medica, Jiangsu Key Laboratory of Pediatric Respiratory Disease, Nanjing 
      University of Chinese Medicine, Nanjing 210023, China.
FAU - Hua, Yongqing
AU  - Hua Y
AD  - Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia 
      Medica, Jiangsu Key Laboratory of Pediatric Respiratory Disease, Nanjing 
      University of Chinese Medicine, Nanjing 210023, China.
FAU - Jiang, Guorong
AU  - Jiang G
AD  - Suzhou Hospital of Traditional Chinese Medicine, Suzhou 215009, China.
FAU - Hong, Min
AU  - Hong M
AD  - Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia 
      Medica, Jiangsu Key Laboratory of Pediatric Respiratory Disease, Nanjing 
      University of Chinese Medicine, Nanjing 210023, China. Electronic address: 
      hongmin72@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180802
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Cadherins)
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Interleukin-33)
RN  - 0 (Isoflavones)
RN  - 0 (Phytoestrogens)
RN  - 0 (RNA, Small Interfering)
RN  - 295DQC67BJ (formononetin)
RN  - 922OP8YUPF (Huang Qi)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Animals
MH  - Astragalus propinquus
MH  - Cadherins/genetics/*metabolism
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Dermatitis, Allergic Contact/*drug therapy
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/therapeutic use
MH  - Epithelial Cells/*drug effects/physiology
MH  - Humans
MH  - Interleukin-33/metabolism
MH  - Isoflavones/*therapeutic use
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Phytoestrogens/*therapeutic use
MH  - RNA, Small Interfering/genetics
MH  - Thymic Stromal Lymphopoietin
OTO - NOTNLM
OT  - Allergic disease
OT  - E-cadherin
OT  - Formononetin
OT  - IL-33
OT  - TSLP
EDAT- 2018/08/06 06:00
MHDA- 2019/08/28 06:00
CRDT- 2018/08/06 06:00
PHST- 2018/02/02 00:00 [received]
PHST- 2018/06/08 00:00 [revised]
PHST- 2018/07/31 00:00 [accepted]
PHST- 2018/08/06 06:00 [pubmed]
PHST- 2019/08/28 06:00 [medline]
PHST- 2018/08/06 06:00 [entrez]
AID - S1521-6616(18)30059-7 [pii]
AID - 10.1016/j.clim.2018.07.018 [doi]
PST - ppublish
SO  - Clin Immunol. 2018 Oct;195:67-76. doi: 10.1016/j.clim.2018.07.018. Epub 2018 Aug 
      2.