PMID- 30078651
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20190314
IS  - 1875-2128 (Electronic)
IS  - 1875-2128 (Linking)
VI  - 111
IP  - 12
DP  - 2018 Dec
TI  - Prophylactic implantable cardioverter defibrillators for primary prevention: From 
      implantation to heart transplantation.
PG  - 758-765
LID - S1875-2136(18)30102-5 [pii]
LID - 10.1016/j.acvd.2018.05.004 [doi]
AB  - BACKGROUND: The frequency, characteristics and outcomes of primary prevention 
      implantable cardioverter defibrillator (ICD) recipients who eventually undergo 
      heart transplantation (HT) during follow-up have not been well described. AIMS: 
      In a cohort of patients with heart failure implanted with an ICD for primary 
      prevention of sudden cardiac death, to identify those at high risk of subsequent 
      HT and evaluate ICD usefulness. METHODS: Between 2002 and 2012, 5539 patients 
      received a primary prevention ICD across 12 centers, and were enrolled in the 
      DAI-PP programme, including 5427 with full HT information available. RESULTS: 
      During a median follow-up of 1024 days (interquartile range 484-1702 days), 176 
      (3.2%) patients underwent HT. Median duration between ICD implantation and HT was 
      484 days (IQR 169-1117 days). Among those aged</=65 years (theoretical age limit 
      for HT registration in France), the overall incidence per 1000 person-years was 
      18.03 (95% confidence interval [CI]: 15.32-20.74). Left ventricular ejection 
      fraction<25% (hazard ratio [HR]: 3.43, 95% CI: 2.34-5.04; P<0.0001), younger age 
      (HR: 0.95, 95% CI: 0.93-0.96; P<0.0001), New York Heart Association (NYHA) class 
      III-IV (HR: 2.67, 95% CI: 1.79-4.00; P<0.0001) and no cardiac resynchronization 
      therapy (HR: 2.09, 95% CI: 1.39-3.14; P=0.0004) were independently associated 
      with HT. Patients with these three characteristics (excluding age) had a 1-year 
      HT rate of 15.2%. Incidence of appropriate ICD therapies was 92.7 per 1000 
      person-years for patients who underwent HT versus 76.1 for those who did not 
      (P=0.64). CONCLUSIONS: The overall incidence of HT in this primary prevention 
      population was relatively high, especially among young patients with a very low 
      ejection fraction, an advanced NYHA class and were unsuitable for cardiac 
      resynchronization therapy (up to 15% annually). Patients awaiting HT experienced 
      a significant rate of appropriate ICD therapies, reinforcing the importance of 
      specific cardiac rhythm management in these patients.
CI  - Copyright (c) 2018. Published by Elsevier Masson SAS.
FAU - Algalarrondo, Vincent
AU  - Algalarrondo V
AD  - CHU Antoine-Beclere, 92140 Clamart, France.
FAU - Perault, Romain
AU  - Perault R
AD  - Universite Francois-Rabelais, CHU Trousseau, 37170 Tours, France.
FAU - Bories, Marie-Cecile
AU  - Bories MC
AD  - Georges-Pompidou European Hospital, 75015 Paris, France.
FAU - Narayanan, Kumar
AU  - Narayanan K
AD  - Paris Cardiovascular Research Centre, 75015 Paris, France; MaxCure Hospitals, 
      Hyderabad, 500081 Telangana, India.
FAU - Garcia, Rodrigue
AU  - Garcia R
AD  - CHU de Poitiers, 86021 Poitiers, France.
FAU - Combes, Nicolas
AU  - Combes N
AD  - Clinique Pasteur, 31076 Toulouse, France.
FAU - Perier, Marie-Cecile
AU  - Perier MC
AD  - Paris Cardiovascular Research Centre, 75015 Paris, France.
FAU - Defaye, Pascal
AU  - Defaye P
AD  - CHU Michallon, 38700 La Tronche, France.
FAU - Sadoul, Nicolas
AU  - Sadoul N
AD  - CHU Brabois, 54500 Vandoeuvre-les-Nancy, France.
FAU - Gras, Daniel
AU  - Gras D
AD  - Nouvelles Cliniques Nantaises, 44202 Nantes, France.
FAU - Klug, Didier
AU  - Klug D
AD  - CHRU de Lille, 59000 Lille, France.
FAU - Bordachar, Pierre
AU  - Bordachar P
AD  - CHU Haut-Leveque, 33600 Pessac, France.
FAU - Fauchier, Laurent
AU  - Fauchier L
AD  - Universite Francois-Rabelais, CHU Trousseau, 37170 Tours, France.
FAU - Deharo, Jean-Claude
AU  - Deharo JC
AD  - CHU La Timone, 13005 Marseille, France.
FAU - Leclercq, Christophe
AU  - Leclercq C
AD  - CHU Pontchaillou, 35000 Rennes, France.
FAU - Boveda, Serge
AU  - Boveda S
AD  - Clinique Pasteur, 31076 Toulouse, France.
FAU - Marijon, Eloi
AU  - Marijon E
AD  - Georges-Pompidou European Hospital, 75015 Paris, France; Paris Cardiovascular 
      Research Centre, 75015 Paris, France; Paris Descartes University, 75006 Paris, 
      France.
FAU - Babuty, Dominique
AU  - Babuty D
AD  - Universite Francois-Rabelais, CHU Trousseau, 37170 Tours, France. Electronic 
      address: d.babuty@chu-tours.fr.
CN  - DAI-PP investigators
AD  - Paris Descartes University, 75006 Paris, France.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20180802
PL  - Netherlands
TA  - Arch Cardiovasc Dis
JT  - Archives of cardiovascular diseases
JID - 101465655
SB  - IM
MH  - Adult
MH  - Aged
MH  - Death, Sudden, Cardiac/epidemiology/*prevention & control
MH  - *Defibrillators, Implantable
MH  - Electric Countershock/adverse effects/*instrumentation/mortality
MH  - Female
MH  - France/epidemiology
MH  - Heart Failure/diagnosis/mortality/physiopathology/*therapy
MH  - *Heart Transplantation/adverse effects/mortality
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Primary Prevention/*instrumentation
MH  - Recovery of Function
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Defibrillateur automatique implantable
OT  - Heart failure
OT  - Heart transplantation
OT  - Implantable cardioverter defibrillator
OT  - Insuffisance cardiaque
OT  - Mort subite
OT  - Mortality
OT  - Mortalite
OT  - Sudden death
OT  - Transplantation cardiaque
EDAT- 2018/08/07 06:00
MHDA- 2019/03/15 06:00
CRDT- 2018/08/07 06:00
PHST- 2017/10/03 00:00 [received]
PHST- 2018/04/30 00:00 [revised]
PHST- 2018/05/14 00:00 [accepted]
PHST- 2018/08/07 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
PHST- 2018/08/07 06:00 [entrez]
AID - S1875-2136(18)30102-5 [pii]
AID - 10.1016/j.acvd.2018.05.004 [doi]
PST - ppublish
SO  - Arch Cardiovasc Dis. 2018 Dec;111(12):758-765. doi: 10.1016/j.acvd.2018.05.004. 
      Epub 2018 Aug 2.