PMID- 30078664
OWN - NLM
STAT- MEDLINE
DCOM- 20190227
LR  - 20190322
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 243
DP  - 2019 Jan 15
TI  - The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A 
      review: Special Section on "Translational and Neuroscience Studies in Affective 
      Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on 
      the relevance of translational and neuroscience studies in providing a better 
      understanding of the neural basis of affective disorders. The main aim is to 
      briefly summaries relevant research findings in clinical neuroscience with 
      particular regards to specific innovative topics in mood and anxiety disorders.
PG  - 552-558
LID - S0165-0327(18)30909-1 [pii]
LID - 10.1016/j.jad.2018.07.054 [doi]
AB  - BACKGROUND: Converging lines of evidence suggest that Brain-Derived Neurotrophic 
      Factor (BDNF) may play a central role in the pathogenesis of Bipolar Disorder 
      (BD), thus representing a valid biomarker of the disease. A common genetic 
      variation in the BDNF gene, the Val66Met, is associated with reduced maturation 
      and secretion of BDNF and therefore it has been related to specific mood, 
      cognitive and neuroanatomical alterations in BD. However, so far, only a handful 
      of studies have investigated the association between Val66Met polymorphism and 
      cognitive functioning in BD. METHODS: We performed a bibliographic search on 
      PUBMED of all genetic studies investigating Val66Met modulation on cognitive 
      performances in BD subjects. The inclusion criteria were met by nine studies, 
      including a total amount of 897 BD subjects and 803 healthy controls. RESULTS: 
      From the analysis of the existing literature emerged that a) Val allele in BD 
      adults, but not in BD adolescents, was associated with better performances in 
      selective cognitive domains including executive functions, verbal learning and 
      memory; b) Met allele may negatively modulate the association between childhood 
      trauma and performances in memory, verbal ability and verbal fluency tasks; c) 
      Met allele may also negatively regulate structural abnormalities in cognitive 
      cerebral structures; d) Val/Met carriers showed greater improvements in cognitive 
      functions compared to Val/Val and Met/Met carriers. LIMITATIONS: Few genetic 
      studies exploring the impact of Val66Met on cognition in BD. CONCLUSIONS: 
      Val66Met polymorphism likely modulates cognitive functions in BD patients with 
      complex gene-environment interactions and through potential modulations of 
      cerebral structures. Further and larger genetic studies are required in order to 
      detect association between BDNF polymorphism, BDNF levels, brain abnormalities 
      and cognition in BD.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Mandolini, G M
AU  - Mandolini GM
AD  - Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, University of Milan, Milan, Italy. Electronic 
      address: gianmario.mandolini@gmail.com.
FAU - Lazzaretti, M
AU  - Lazzaretti M
AD  - Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
FAU - Pigoni, A
AU  - Pigoni A
AD  - Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
FAU - Delvecchio, G
AU  - Delvecchio G
AD  - Department of Pathophysiology and Transplantation, University of Milan, Milan, 
      Italy.
FAU - Soares, J C
AU  - Soares JC
AD  - Department of Psychiatry and Behavioural Neurosciences, University of Texas, 
      Houston, TX, USA.
FAU - Brambilla, P
AU  - Brambilla P
AD  - Department of Pathophysiology and Transplantation, University of Milan, Milan, 
      Italy; Scientific Institute IRCCS "E. Medea", Bosisio Parini (Lc), Italy. 
      Electronic address: paolo.brambilla1@unimi.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180724
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Anxiety Disorders/genetics
MH  - Bipolar Disorder/*genetics/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Executive Function
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mood Disorders/*genetics/metabolism
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - BDNF
OT  - Bipolar Disorder
OT  - Cognition
OT  - Single-nucleotide polymorphism
EDAT- 2018/08/07 06:00
MHDA- 2019/02/28 06:00
CRDT- 2018/08/07 06:00
PHST- 2018/04/27 00:00 [received]
PHST- 2018/07/12 00:00 [revised]
PHST- 2018/07/20 00:00 [accepted]
PHST- 2018/08/07 06:00 [pubmed]
PHST- 2019/02/28 06:00 [medline]
PHST- 2018/08/07 06:00 [entrez]
AID - S0165-0327(18)30909-1 [pii]
AID - 10.1016/j.jad.2018.07.054 [doi]
PST - ppublish
SO  - J Affect Disord. 2019 Jan 15;243:552-558. doi: 10.1016/j.jad.2018.07.054. Epub 
      2018 Jul 24.