PMID- 30078796
OWN - NLM
STAT- MEDLINE
DCOM- 20190705
LR  - 20190705
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 59
IP  - 7
DP  - 2018
TI  - [FGFR1-mutated B-cell acute lymphoblastic leukemia transforming to 
      myelodysplastic / myeloproliferative neoplasm and acute myeloid leukemia].
PG  - 872-877
LID - 10.11406/rinketsu.59.872 [doi]
AB  - A 77-year-old male with hyperleukocytosis and thrombocytopenia was diagnosed with 
      Philadelphia chromosome (Ph) -negative B-cell acute lymphoblastic leukemia (ALL) 
      ; he was treated with induction chemotherapy. Despite an initial complete 
      remission, hyperleukocytosis was returned 18 months later. A bone marrow smear 
      revealed a substantial increase in the number of myeloid cells with each stage of 
      differentiation, which was markedly different from the initial presentation, 
      resulting in the diagnosis of Ph-negative myelodysplastic 
      syndrome/myeloproliferative neoplasm (MDS/MPN). After a month, an autopsy 
      revealed that the disease had progressed to acute myelogenous leukemia (AML). 
      Since the first diagnosis, a chromosomal translocation, t (8;13) (p12;q12), was 
      identified; this was subsequently confirmed by fluorescence in situ hybridization 
      (FISH) analysis to comprise a genomic rearrangement of the fibroblast growth 
      factor receptor 1 (FGFR1) gene. Collectively, this is a rare case of a 
      myeloid/lymphoid neoplasm with an FGFR1 genomic rearrangement that initially 
      presented as B-cell ALL, before developing into MDS/MPN and finally into AML. In 
      the literature, although a transformation of MPN into ALL is often reported, the 
      transformation of B-cell ALL into MPN is an infrequent event.
FAU - Ide, Shiro
AU  - Ide S
AD  - Department of Hematology, Eiju General Hospital.
FAU - Ohara, Shin
AU  - Ohara S
AD  - Department of Hematology, Eiju General Hospital.
FAU - Inoue, Morihiro
AU  - Inoue M
AD  - Department of Hematology, Eiju General Hospital.
FAU - Hua, Jian
AU  - Hua J
AD  - Department of Hematology, Eiju General Hospital.
FAU - Hagihara, Masao
AU  - Hagihara M
AD  - Department of Hematology, Eiju General Hospital.
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - EC 2.7.10.1 (FGFR1 protein, human)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
SB  - IM
MH  - Aged
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics/pathology
MH  - Male
MH  - Myelodysplastic Syndromes/*genetics/pathology
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/pathology
MH  - Receptor, Fibroblast Growth Factor, Type 1/*genetics
OTO - NOTNLM
OT  - Acute lymphoblastic leukemia (ALL)
OT  - FGFR1
OT  - MDS/MPN
OT  - t(8;13)(p12;q12)
EDAT- 2018/08/07 06:00
MHDA- 2019/07/06 06:00
CRDT- 2018/08/07 06:00
PHST- 2018/08/07 06:00 [entrez]
PHST- 2018/08/07 06:00 [pubmed]
PHST- 2019/07/06 06:00 [medline]
AID - 10.11406/rinketsu.59.872 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2018;59(7):872-877. doi: 10.11406/rinketsu.59.872.