PMID- 30078837
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20180816
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 43
IP  - 8
DP  - 2018
TI  - Assessment of the skin sensitizing potential of chemicals, contained in foods 
      and/or cosmetic ingredients, using a modified local lymph node assay with an 
      elicitation phase (LLNA:DAE) method.
PG  - 513-520
LID - 10.2131/jts.43.513 [doi]
AB  - We evaluated the skin sensitizing potential of 10 natural organic chemicals, or 
      their derivatives, which are included in foods and/or skin products, using a 
      modified local lymph node assay (LLNA), with an elicitation phase (LLNA:DAE). The 
      following compounds were tested: carminic acid, esculetin, 4-methyl esculetin, 
      coumarin, quercetin, curcumin, naringenin, chlorogenic acid, isoscopoletin, and 
      shikonin. Esculetin, 4-methyl esculetin, isoscopoletin, and shikonin yielded 
      positive results. In particular, shikonin at a very low concentration (0.05%) 
      induced an elicitation response. In conclusion, four of the 10 natural organic 
      chemicals tested had a skin sensitization potential, with shikonin producing 
      serious reaction even at a very low concentration.
FAU - Yamashita, Kunihiko
AU  - Yamashita K
AD  - Corporate Research Center, Daicel Corporation.
FAU - Miyazaki, Hiroshi
AU  - Miyazaki H
AD  - Corporate Research Center, Daicel Corporation.
FAU - Shinoda, Shinsuke
AU  - Shinoda S
AD  - Yoshimi Laboratories, Drug Safety Testing Center Co., Ltd.
FAU - Hagiwara, Saori
AU  - Hagiwara S
AD  - Yoshimi Laboratories, Drug Safety Testing Center Co., Ltd.
FAU - Takahashi, Hirohito
AU  - Takahashi H
AD  - Yoshimi Laboratories, Drug Safety Testing Center Co., Ltd.
FAU - Itagaki, Hiroshi
AU  - Itagaki H
AD  - Faculty of Engineering, Dept. of Materials Science and Engineering, Yokohama 
      National University.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Cosmetics)
RN  - 0 (Coumarins)
RN  - 0 (Naphthoquinones)
RN  - 0 (Umbelliferones)
RN  - 3IK6592UBW (shikonin)
RN  - 9IKM0I5T1E (Quercetin)
RN  - A4VZ22K1WT (coumarin)
RN  - CID8Z8N95N (Carmine)
RN  - IT942ZTH98 (Curcumin)
RN  - SM2XD6V944 (esculetin)
SB  - IM
MH  - Animals
MH  - Carmine/*adverse effects
MH  - Cosmetics/*chemistry
MH  - Coumarins/adverse effects
MH  - Curcumin/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - *Food Analysis
MH  - *Local Lymph Node Assay
MH  - Mice, Inbred CBA
MH  - Naphthoquinones/*adverse effects
MH  - Quercetin/*adverse effects
MH  - Skin/*drug effects
MH  - Skin Irritancy Tests/*methods
MH  - Umbelliferones/*adverse effects
OTO - NOTNLM
OT  - Cosmetics
OT  - Food
OT  - Skin sensitization
EDAT- 2018/08/07 06:00
MHDA- 2018/08/17 06:00
CRDT- 2018/08/07 06:00
PHST- 2018/08/07 06:00 [entrez]
PHST- 2018/08/07 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
AID - 10.2131/jts.43.513 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2018;43(8):513-520. doi: 10.2131/jts.43.513.