PMID- 30080693
OWN - NLM
STAT- MEDLINE
DCOM- 20190517
LR  - 20190517
IS  - 1542-233X (Electronic)
IS  - 1542-2321 (Linking)
VI  - 45
IP  - 2
DP  - 2019 Mar
TI  - Comparative Analysis of Adverse Events From a Series of Proof-of-Principle 
      Extended Wear Studies.
PG  - 88-92
LID - 10.1097/ICL.0000000000000546 [doi]
AB  - AIM: A series of proof-of-principle extended wear (EW) contact lens studies were 
      conducted to assess what effect different interventions had on adverse events 
      (AEs). Comparative analysis of AEs across studies was conducted to determine 
      whether some interventions were more effective at reducing inflammatory AEs. 
      METHOD: Multiple logistic regression analysis of AEs from 30-day EW studies each 
      with a different intervention including (1) nightly replacement (NR) of lenses, 
      (2) morning replacement (MR) of lenses, (3) instillation of prophylactic 
      antibiotic drops (AB) each morning/evening, (4) daily lens cleaning (LC) each 
      morning. All studies conducted at the same site using same lens type (lotrafilcon 
      A) and EW schedule. RESULTS: Comparison of the different interventions to the 
      individual control groups showed no difference in significant corneal 
      infiltrative event (CIE) or mechanical events. Replacing lenses nightly, during 
      an EW schedule, had the highest incidence of significant CIEs (4.9% [NR] vs. 2.5% 
      [MR] vs. 1.8% [AB] vs. 0% [LC]); however, adjusted logistic regression analysis 
      of the combined control data compared with the individual interventions showed no 
      difference in significant CIEs (P=0.086) or mechanical AEs (P=0.140). 
      CONCLUSIONS: Replacing lenses each night seemed to be inferior compared with the 
      other interventions of replacing lenses each morning, daily lens cleaning, and 
      daily antibiotic drop instillation during EW. The results of the collective 
      studies and additional analysis suggest that overnight wear of contact lenses 
      seems to create an adverse environment that remains, despite the various 
      interventions intended to improve this adverse environment.
FAU - Ozkan, Jerome
AU  - Ozkan J
AD  - School of Optometry and Vision Science (J.O., P.L.d.l.J., M.W.), University of 
      New South Wales, Sydney, New South Wales, Australia; Currently Director of 
      Research Programs (P.L.d.l.J.), CooperVision, Pleasanton, CA.
FAU - Lazon de la Jara, Percy
AU  - Lazon de la Jara P
FAU - Willcox, Mark
AU  - Willcox M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Eye Contact Lens
JT  - Eye & contact lens
JID - 101160941
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Ophthalmic Solutions)
SB  - IM
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Contact Lenses, Extended-Wear/*adverse effects
MH  - Disposable Equipment
MH  - Eye Infections, Bacterial/epidemiology/*prevention & control
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Ophthalmic Solutions
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2018/08/07 06:00
MHDA- 2019/05/18 06:00
CRDT- 2018/08/07 06:00
PHST- 2018/08/07 06:00 [pubmed]
PHST- 2019/05/18 06:00 [medline]
PHST- 2018/08/07 06:00 [entrez]
AID - 10.1097/ICL.0000000000000546 [doi]
PST - ppublish
SO  - Eye Contact Lens. 2019 Mar;45(2):88-92. doi: 10.1097/ICL.0000000000000546.