PMID- 30082011
OWN - NLM
STAT- MEDLINE
DCOM- 20181218
LR  - 20181218
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 47
IP  - 3
DP  - 2018 May
TI  - [Effects of maternal exposure to bisphenol A during pregnancy on puberty in 
      advance and hypothalamo-pituitary gonadal axis hormones level in female 
      offspring].
PG  - 425-431
AB  - OBJECTIVE: To investigate the effect of maternal exposure to bisphenol A on 
      puberty in advance and hypothalamus-pituitary-gonad axis( HPG axis) hormones 
      level in female offspring. METHODS: A total of 105 pregnant CD-1 mice aged 8 
      weeks were daily administered with BPA at four different doses( 0, 8, 40 and 200 
      mg/kg) by gavage from gestational day( GD) 0 to 18. Offspring were weighed and 
      determined sex by anal reproductive distance after birth. From postnatal day( 
      PND) 21-34, the vaginal opening of female offspring and distinguished the estrous 
      stage through vaginal smears wereobserved. The level of GnRH, FSH, LH and E2 
      hormone in serum were detected. RESULTS: The mean initial time of vaginal opening 
      in 8 mg/kg group [( 28. 0 +/- 0. 36)days], 40 mg/kg group [( 28. 0 +/- 0. 33) days] 
      and 200 mg/kg group [( 28. 0 +/- 0. 61)days]was earlier than that in the control 
      group [( 30. 0 +/- 0. 27) days]. The vaginal opening in advance rate of BPA 
      exposure group was higher than that of the control group and the first estrus 
      occurrence was earlier than controls( P < 0. 05). The levels of GnRH[8 mg/kg:( 9. 
      78 +/- 1. 07) pg/mL, 40 mg/kg:( 11. 55 +/- 1. 38) pg/mL, 200 mg/kg:( 10. 09 +/- 1. 51) 
      pg/mL]with increased expressions compared with the controls [( 5. 18+/- 4. 63) 
      pg/mL]. LH level in low dose group [( 1. 86 +/- 0. 79) pg/mL] was significantly 
      lower than that in control group [( 2. 37 +/- 1. 56) pg/mL]. The above differences 
      were statistically significant( P < 0. 05). CONCLUSION: These findings suggested 
      that maternal exposure to BPA result in advancing puberty and increase the GnRH 
      hormone level to affect the function of HPG axis in female offspring.
FAU - Xu, Geng
AU  - Xu G
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Anhui Medical University, Hefei 230032, China.
FAU - Han, Azhu
AU  - Han A
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Anhui Medical University, Hefei 230032, China.
FAU - Xu, Nuo
AU  - Xu N
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Anhui Medical University, Hefei 230032, China.
FAU - Su, Puyu
AU  - Su P
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Anhui Medical University, Hefei 230032, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds/*toxicity
MH  - Female
MH  - Humans
MH  - Hypothalamo-Hypophyseal System/*drug effects/metabolism
MH  - Hypothalamus/drug effects/metabolism
MH  - *Maternal Exposure
MH  - Mice
MH  - Phenols/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*physiopathology
MH  - Sexual Maturation/*drug effects/physiology
OTO - NOTNLM
OT  - animal experiment
OT  - bisphenol A
OT  - environmental toxicology
OT  - hypothalamo-pituitary gonadal axis
OT  - puberty in advance
EDAT- 2018/08/08 06:00
MHDA- 2018/12/19 06:00
CRDT- 2018/08/08 06:00
PHST- 2018/08/08 06:00 [entrez]
PHST- 2018/08/08 06:00 [pubmed]
PHST- 2018/12/19 06:00 [medline]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2018 May;47(3):425-431.