PMID- 30083436
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230928
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 6
DP  - 2018
TI  - Identification of exosome-like nanoparticle-derived microRNAs from 11 edible 
      fruits and vegetables.
PG  - e5186
LID - 10.7717/peerj.5186 [doi]
LID - e5186
AB  - Edible plant-derived exosome-like nanoparticles (EPDELNs) are novel naturally 
      occurring plant ultrastructures that are structurally similar to exosomes. Many 
      EPDELNs have anti-inflammatory properties. MicroRNAs (miRNAs) play a critical 
      role in mediating physiological and pathological processes in animals and plants. 
      Although miRNAs can be selectively encapsulated in extracellular vesicles, little 
      is known about their expression and function in EPDELNs. In this study, we 
      isolated nanovesicles from 11 edible fruits and vegetables and subjected the 
      corresponding EPDELN small RNA libraries to Illumina sequencing. We identified a 
      total of 418 miRNAs-32 to 127 per species-from the 11 EPDELN samples. Target 
      prediction and functional analyses revealed that highly expressed miRNAs were 
      closely associated with the inflammatory response and cancer-related pathways. 
      The 418 miRNAs could be divided into three classes according to their EPDELN 
      distributions: 26 "frequent" miRNAs (FMs), 39 "moderately present" miRNAs (MPMs), 
      and 353 "rare" miRNAs (RMs). FMs were represented by fewer miRNA species than RMs 
      but had a significantly higher cumulative expression level. Taken together, our 
      in vitro results indicate that miRNAs in EPDELNs have the potential to regulate 
      human mRNA.
FAU - Xiao, Juan
AU  - Xiao J
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
FAU - Feng, Siyuan
AU  - Feng S
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
FAU - Wang, Xun
AU  - Wang X
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
FAU - Long, Keren
AU  - Long K
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
FAU - Luo, Yi
AU  - Luo Y
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
FAU - Wang, Yuhao
AU  - Wang Y
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
FAU - Ma, Jideng
AU  - Ma J
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
FAU - Tang, Qianzi
AU  - Tang Q
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
FAU - Jin, Long
AU  - Jin L
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
FAU - Li, Xuewei
AU  - Li X
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
FAU - Li, Mingzhou
AU  - Li M
AD  - Sichuan Agricultural University, Institute of Animal Genetics and Breeding, 
      College of Animal Science and Technology, Chengdu, People's Republic of China.
AD  - Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and 
      Innovation Key Laboratory of Sichuan Province, Chengdu, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
DEP - 20180731
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC6074755
OTO - NOTNLM
OT  - Cross-kingdom
OT  - Exosome-like nanoparticles
OT  - Illumina sequencing
OT  - miRNA expression profile
OT  - miRNAs expression profile
COIS- The authors declare there are no competing interests.
EDAT- 2018/08/08 06:00
MHDA- 2018/08/08 06:01
PMCR- 2018/07/31
CRDT- 2018/08/08 06:00
PHST- 2018/03/18 00:00 [received]
PHST- 2018/06/15 00:00 [accepted]
PHST- 2018/08/08 06:00 [entrez]
PHST- 2018/08/08 06:00 [pubmed]
PHST- 2018/08/08 06:01 [medline]
PHST- 2018/07/31 00:00 [pmc-release]
AID - 5186 [pii]
AID - 10.7717/peerj.5186 [doi]
PST - epublish
SO  - PeerJ. 2018 Jul 31;6:e5186. doi: 10.7717/peerj.5186. eCollection 2018.