PMID- 30083439
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 6
DP  - 2018
TI  - Single nucleotide polymorphisms within HLA region are associated with disease 
      relapse for patients with unrelated cord blood transplantation.
PG  - e5228
LID - 10.7717/peerj.5228 [doi]
LID - e5228
AB  - Disease relapse occurs in unrelated cord blood transplantation (CBT) even when 
      the alleles of human leukocyte antigen (HLA) are fully matched between donor and 
      recipient. This is similar to that observed in other types of hematopoietic stem 
      cell transplantation. Fourteen single nucleotide polymorphisms (SNPs) within the 
      HLA region have been reported previously by Petersdorf et al. and Piras et al. as 
      transplantation determinants in unrelated hematopoietic cell transplantation. In 
      this study, the genomic sequences within 500 base pairs upstream and downstream 
      of the fourteen transplantation-related SNPs from 53 patients and their 
      HLA-matched unrelated donors were analyzed for determining whether or not genetic 
      variants, conferred by either recipient or donor SNP genotype or by 
      recipient-donor SNP mismatching, were associated with the risk of relapse. Seven 
      SNPs were associated with the risk of relapse in unrelated CBT. These included 
      the donor genotype with the SNPs of rs2523675 and rs2518028 at the telomeric end 
      of HCP5 gene, rs2071479 in the intron of the HLA-DOB gene, and rs2523958 in the 
      MICD gene; and the recipient genotype with SNPs of rs9276982 in the HLA-DOA gene, 
      and rs435766 and rs380924 in the MICD gene. As measured by pair-wise linkage 
      disequilibrium (LD) with D' as the parameter for normalized standard measurement 
      of LD which compares the observed and expected frequencies of one haplotype 
      comprised by alleles at different loci, rs2523675 had high LD with rs4713466 (D' 
      = 0.86) and rs2523676 (D' = 0.91) in the HCP5 gene. The rs2518028 had no LD with 
      all other SNPs except rs2523675 (D' = 0.76). This study provides the basis for 
      developing a method or algorithm for selecting better unrelated CBT candidate 
      donors.
FAU - Chen, Ding-Ping
AU  - Chen DP
AD  - Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
AD  - Department of Medical Biotechnology and Laboratory Science, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan.
AD  - Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Chang, Su-Wei
AU  - Chang SW
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital, Taoyuan, Taiwan.
AD  - Clinical Informatics and Medical Statistics Research Center, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan.
FAU - Jaing, Tang-Her
AU  - Jaing TH
AD  - Division of Hematology and Oncology, Department of Pediatrics, Chang Gung 
      Children's Hospital, Taoyuan, Taiwan.
FAU - Wang, Wei-Ting
AU  - Wang WT
AD  - Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Hus, Fang-Ping
AU  - Hus FP
AD  - Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Tseng, Ching-Ping
AU  - Tseng CP
AD  - Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
AD  - Department of Medical Biotechnology and Laboratory Science, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan.
AD  - Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung 
      University, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20180802
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC6076982
OTO - NOTNLM
OT  - Cord blood transplantation
OT  - Hematopoietic stem cell transplantation
OT  - Human leukocyte antigen
OT  - Linkage disequilibrium
OT  - Major histocompatibility complex
OT  - Single nucleotide polymorphisms
COIS- The authors declare that they have no competing interests.
EDAT- 2018/08/08 06:00
MHDA- 2018/08/08 06:01
PMCR- 2018/08/02
CRDT- 2018/08/08 06:00
PHST- 2017/12/05 00:00 [received]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2018/08/08 06:00 [entrez]
PHST- 2018/08/08 06:00 [pubmed]
PHST- 2018/08/08 06:01 [medline]
PHST- 2018/08/02 00:00 [pmc-release]
AID - 5228 [pii]
AID - 10.7717/peerj.5228 [doi]
PST - epublish
SO  - PeerJ. 2018 Aug 2;6:e5228. doi: 10.7717/peerj.5228. eCollection 2018.