PMID- 30084012 OWN - NLM STAT- MEDLINE DCOM- 20181101 LR - 20220801 IS - 1179-1969 (Electronic) IS - 1170-229X (Linking) VI - 35 IP - 9 DP - 2018 Sep TI - Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry. PG - 843-857 LID - 10.1007/s40266-018-0572-0 [doi] AB - BACKGROUND: With the aging of the hepatitis C virus (HCV)-infected patient cohort and the availability of highly effective and tolerable treatment regimens, an increasing number of elderly patients are now eligible for HCV therapy. This study investigated clinical and epidemiologic characteristics of elderly HCV-infected patients as well as the effectiveness and safety of available therapies. METHODS: Patients were enrolled into the German Hepatitis C Registry (DHC-R), a prospective, multicenter, real-world cohort study. Patients were treated at the discretion of the physician, and data were collected by a web-based system. RESULTS: Of 7133 patients who initiated treatment, 686 (9.6%) were > 70 years of age. In patients > 70 years, intent-to-treat (ITT) SVR12 was 92.6% (514/555) compared to 90.7% (4521/4985) in patients 70 or 70 or 70 years of age. Frequent comorbidities in patients > 70 years of age were cardiac disease, renal disease and diabetes. Psychiatric disorders, substance abuse and viral co-infection were more frequent in younger patients. CONCLUSION: Direct-acting antiviral therapies were well tolerated in patients older than 70 years. SVR12 rates in the elderly patient group were similar to those observed in younger patients. Differences in the prevalence of comorbidities between age groups warrant individualized attention with respect to drug-drug interactions and therapy adherence. The study was registered in the German Clinical Trials Register, DRKS-ID: DRKS00009717. FAU - Dultz, Georg AU - Dultz G AUID- ORCID: 0000-0003-0775-0907 AD - Department of Medicine 1, J.W. Goethe University Frankfurt, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany. georg.dultz@kgu.de. FAU - Muller, Tobias AU - Muller T AD - Charite Campus Virchow-Klinikum (CVK), Berlin, Germany. FAU - Petersen, Jorg AU - Petersen J AD - ifi-Institute for Interdisciplinary Medicine, Hamburg, Germany. FAU - Mauss, Stefan AU - Mauss S AD - Center for HIV and Hepatogastroenterology, Dusseldorf, Germany. FAU - Zimmermann, Tim AU - Zimmermann T AD - University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. FAU - Muche, Marion AU - Muche M AD - Charite Campus Virchow-Klinikum (CVK), Berlin, Germany. FAU - Simon, Karl-Georg AU - Simon KG AD - Hepatologische Praxis, Leverkusen, Germany. FAU - Berg, Thomas AU - Berg T AD - University Hospital Leipzig, Leipzig, Germany. FAU - Zeuzem, Stefan AU - Zeuzem S AD - Department of Medicine 1, J.W. Goethe University Frankfurt, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany. FAU - Huppe, Dietrich AU - Huppe D AD - Hepatologische Schwerpunktpraxis, Herne, Germany. FAU - Boker, Klaus AU - Boker K AD - Hepatologische Praxis, Hannover, Germany. FAU - Wedemeyer, Heiner AU - Wedemeyer H AD - Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg Essen, Essen, Germany. AD - Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. AD - Leberstiftungs-GmbH Deutschland, Hannover, Germany. FAU - Welzel, Tania M AU - Welzel TM AD - Department of Medicine 1, J.W. Goethe University Frankfurt, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany. CN - Leberstiftungs-GmbH Deutschland LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - New Zealand TA - Drugs Aging JT - Drugs & aging JID - 9102074 RN - 0 (Antiviral Agents) SB - IM MH - Adult MH - Aged MH - Antiviral Agents/*adverse effects/pharmacology/*therapeutic use MH - Drug Therapy, Combination MH - Female MH - Germany/*epidemiology MH - Hepacivirus/*drug effects/physiology MH - Hepatitis C, Chronic/*drug therapy/epidemiology MH - Humans MH - Immunotherapy, Adoptive MH - Male MH - Middle Aged MH - *Registries MH - *Safety MH - Treatment Outcome FIR - Gunther, Rainer IR - Gunther R FIR - Hinrichsen, Holger IR - Hinrichsen H FIR - Heyne, Renate IR - Heyne R FIR - Roth, Johannes IR - Roth J FIR - Goeser, Tobias IR - Goeser T FIR - Ullrich, Rainer IR - Ullrich R FIR - John, Christine IR - John C FIR - Hofmann, Wolf Peter IR - Hofmann WP FIR - Teuber, Gerlinde IR - Teuber G FIR - Moller, Hjordis IR - Moller H FIR - Baumgarten, Axel IR - Baumgarten A FIR - Schwenzer, Jeannette IR - Schwenzer J FIR - Pathil, Anita IR - Pathil A FIR - Kraus, Michael R IR - Kraus MR FIR - Weber, Andreas IR - Weber A FIR - Jung, Maria-Christina IR - Jung MC FIR - Gerken, Guido IR - Gerken G FIR - Antoni, Christoph IR - Antoni C FIR - Doss, Margareta Frank IR - Doss MF FIR - Schober, Andreas IR - Schober A FIR - Hoffstadt, Martin IR - Hoffstadt M FIR - Lucadou, Armand V IR - Lucadou AV FIR - Steffens, Hermann IR - Steffens H FIR - Klinker, Hartwig IR - Klinker H FIR - Geier, Andreas IR - Geier A FIR - Klausen, Gerd IR - Klausen G FIR - Buggisch, Peter IR - Buggisch P FIR - Cornberg, Markus IR - Cornberg M FIR - Sarrazin, Christoph IR - Sarrazin C FIR - Manns, Michael P IR - Manns MP FIR - Niederau, Claus IR - Niederau C FIR - Protzer, Ulla IR - Protzer U FIR - Schirmacher, Peter IR - Schirmacher P EDAT- 2018/08/08 06:00 MHDA- 2018/11/02 06:00 CRDT- 2018/08/08 06:00 PHST- 2018/08/08 06:00 [pubmed] PHST- 2018/11/02 06:00 [medline] PHST- 2018/08/08 06:00 [entrez] AID - 10.1007/s40266-018-0572-0 [pii] AID - 10.1007/s40266-018-0572-0 [doi] PST - ppublish SO - Drugs Aging. 2018 Sep;35(9):843-857. doi: 10.1007/s40266-018-0572-0.