PMID- 30084177
OWN - NLM
STAT- MEDLINE
DCOM- 20190501
LR  - 20190501
IS  - 1479-8301 (Electronic)
IS  - 1346-3500 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Jan
TI  - Medial temporal lobe atrophy is independently associated with behavioural and 
      psychological symptoms in Alzheimer's disease.
PG  - 46-54
LID - 10.1111/psyg.12363 [doi]
AB  - AIM: Evidence describing the contribution of cerebral white matter disease and 
      medial temporal atrophy (MTA) to behavioural and psychological symptoms of 
      dementia (BPSD) has been conflicting. The aim of this study was to assess the 
      relationship of white matter hyperintensities (WMH) and MTA observed on magnetic 
      resonance imaging with BPSD among patients with Alzheimer's disease. METHODS: In 
      a cross-sectional study of a prospective cohort of patients attending a memory 
      clinic, 46 patients with probable Alzheimer's disease (mean age: 72.38 +/- 7.05 
      years) were studied. Sociodemographic, cognitive, and BPSD data were collected. 
      BPSD were assessed using the Neuropsychiatric Inventory. Magnetic resonance 
      imaging, WMH, and MTA were rated using the Scheltens scales for the assessment of 
      signal hyperintensities and atrophy of medial temporal lobes. For multivariate 
      analysis, two binary logistic regression analyses were carried out, with presence 
      or absence of each BPSD as the dependent variable and with WMH or MTA as the 
      predictor variable. Results of the logistic regression were analyzed to see if 
      the significance of the WMH or MTA score was maintained in a model that factored 
      in other possible confounding variables identified in univariate analysis. 
      RESULTS: The results of binary logistic regression analysis showed that in models 
      that accounted for confounding variables, increased total MTA was significantly 
      associated with apathy (odds ratio = 1.605, adjusted P = 0.042) and disinhibition 
      (odds ratio = 0.607, adjusted P = 0.042). WMH measures did not significantly 
      predict any BPSD item. CONCLUSIONS: These findings indicate that MTA potentially 
      contributes to the aetiology of BPSD, and they provide evidence to support the 
      hypothesis that Alzheimer's disease pathology itself can contribute to BPSD.
CI  - (c) 2018 Japanese Psychogeriatric Society.
FAU - Garcia-Alberca, Jose Maria
AU  - Garcia-Alberca JM
AD  - Alzheimer Research Center and Memory Clinic, Andalusian Institute for 
      Neuroscience, Malaga, Spain.
FAU - Florido, Mercedes
AU  - Florido M
AD  - Alzheimer Research Center and Memory Clinic, Andalusian Institute for 
      Neuroscience, Malaga, Spain.
FAU - Caceres, Marta
AU  - Caceres M
AD  - Alzheimer Research Center and Memory Clinic, Andalusian Institute for 
      Neuroscience, Malaga, Spain.
FAU - Sanchez-Toro, Alicia
AU  - Sanchez-Toro A
AD  - Alzheimer Research Center and Memory Clinic, Andalusian Institute for 
      Neuroscience, Malaga, Spain.
FAU - Lara, Jose Pablo
AU  - Lara JP
AD  - Unit of Cognitive Neurophysiology, Research Medical Center of Malaga University, 
      Biomedical Research Institute of Malaga, Malaga, Spain.
FAU - Garcia-Casares, Natalia
AU  - Garcia-Casares N
AD  - Department of Medicine, Faculty of Medicine, University of Malaga, Research 
      Medical Center of Malaga University, Biomedical Research Institute of Malaga, 
      Malaga, Spain.
LA  - eng
PT  - Journal Article
DEP - 20180806
PL  - England
TA  - Psychogeriatrics
JT  - Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
JID - 101230058
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*pathology/physiopathology/*psychology
MH  - Atrophy
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Geriatric Assessment/methods/*statistics & numerical data
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Neuropsychological Tests
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Temporal Lobe/*diagnostic imaging/*pathology/physiopathology
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - behavioural and psychological symptoms of dementia
OT  - magnetic resonance imaging
OT  - medial temporal lobe atrophy
OT  - white matter hyperintensities
EDAT- 2018/08/08 06:00
MHDA- 2019/05/02 06:00
CRDT- 2018/08/08 06:00
PHST- 2017/11/01 00:00 [received]
PHST- 2018/01/31 00:00 [revised]
PHST- 2018/06/29 00:00 [accepted]
PHST- 2018/08/08 06:00 [pubmed]
PHST- 2019/05/02 06:00 [medline]
PHST- 2018/08/08 06:00 [entrez]
AID - 10.1111/psyg.12363 [doi]
PST - ppublish
SO  - Psychogeriatrics. 2019 Jan;19(1):46-54. doi: 10.1111/psyg.12363. Epub 2018 Aug 6.