PMID- 30085311
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20200220
IS  - 1525-3171 (Electronic)
IS  - 0032-5791 (Linking)
VI  - 97
IP  - 12
DP  - 2018 Dec 1
TI  - Betaine improves the growth performance and muscle growth of partridge shank 
      broiler chickens via altering myogenic gene expression and insulin-like growth 
      factor-1 signaling pathway.
PG  - 4297-4305
LID - 10.3382/ps/pey303 [doi]
AB  - This study was conducted to investigate the effect of betaine on growth 
      performance, carcass characteristics, myogenic gene expression, and insulin-like 
      growth factor-1 (IGF-1) signaling pathway in partridge shank broiler chickens. A 
      total of 192 one-day-old partridge shank broiler chickens were randomly divided 
      into 4 groups with 6 replicates of 8 chickens for a 52-d feeding trial. Broilers 
      were fed a basal diet supplemented with 0 (control), 250 (B250), 500 (B500), or 
      1,000 (B1000) mg/kg betaine. Compared with the control group, the B500 and B1000 
      groups had higher (P < 0.05) body weight gain (BWG), and the B500 group had a 
      lower (P < 0.05) feed/gain ratio (F:G) during the whole trial period. Moreover, 
      the B1000 group increased (P < 0.05) the breast muscle yield and decreased (P < 
      0.05) relative abdominal fat weight. The mRNA expression of myocyte enhancer 
      factor 2B (MEF2B) and mechanistic target of rapamycin (mTOR) and mTOR 
      phosporylation were higher (P < 0.05) in both breast and thigh muscles in the 
      B500 and B1000 groups than those in the control group. The higher (P < 0.05) 
      concentration and mRNA expression of IGF-1 were also observed in breast muscle in 
      the B500 and B1000 groups. Additionally, the B1000 group up-regulated (P < 0.05) 
      the mRNA level of myogenic differentiation factor 1 (MyoD1) in breast muscle and 
      myogenin (MyoG) in thigh muscle. In conclusion, diets supplemented with 500 or 
      1,000 mg/kg betaine improved the growth performance of partridge shank broiler 
      chickens during the whole trial period, and the B1000 group significantly 
      improved the breast muscle growth. These improvements might result from increased 
      mRNA expression of MyoD1 and MEF2B in breast muscle and MyoG and MEF2B in thigh 
      muscle, and through alterations in IGF-1/mTOR signaling pathway.
FAU - Chen, R
AU  - Chen R
AD  - College of Animal Science and Technology, Nanjing Agricultural University, 
      Nanjing 210095, China.
FAU - Zhuang, S
AU  - Zhuang S
AD  - College of Animal Science and Technology, Nanjing Agricultural University, 
      Nanjing 210095, China.
FAU - Chen, Y P
AU  - Chen YP
AD  - College of Animal Science and Technology, Nanjing Agricultural University, 
      Nanjing 210095, China.
FAU - Cheng, Y F
AU  - Cheng YF
AD  - College of Animal Science and Technology, Nanjing Agricultural University, 
      Nanjing 210095, China.
FAU - Wen, C
AU  - Wen C
AD  - College of Animal Science and Technology, Nanjing Agricultural University, 
      Nanjing 210095, China.
FAU - Zhou, Y M
AU  - Zhou YM
AD  - College of Animal Science and Technology, Nanjing Agricultural University, 
      Nanjing 210095, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Poult Sci
JT  - Poultry science
JID - 0401150
RN  - 0 (Avian Proteins)
RN  - 0 (Muscle Proteins)
RN  - 3SCV180C9W (Betaine)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animal Feed/analysis
MH  - Animals
MH  - Avian Proteins/*genetics
MH  - Betaine/*administration & dosage
MH  - Chickens/genetics/growth & development/*physiology
MH  - Diet/veterinary
MH  - Dietary Supplements/analysis
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression/*drug effects
MH  - Insulin-Like Growth Factor I/genetics
MH  - Muscle Development/*drug effects/genetics
MH  - Muscle Proteins/*genetics
MH  - Random Allocation
MH  - Signal Transduction/*drug effects/physiology
EDAT- 2018/08/08 06:00
MHDA- 2019/01/12 06:00
CRDT- 2018/08/08 06:00
PHST- 2018/01/23 00:00 [received]
PHST- 2018/06/25 00:00 [accepted]
PHST- 2018/08/08 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2018/08/08 06:00 [entrez]
AID - S0032-5791(19)30259-7 [pii]
AID - 10.3382/ps/pey303 [doi]
PST - ppublish
SO  - Poult Sci. 2018 Dec 1;97(12):4297-4305. doi: 10.3382/ps/pey303.