PMID- 30086547
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20190903
IS  - 2296-5262 (Electronic)
IS  - 2296-5270 (Linking)
VI  - 41
IP  - 9
DP  - 2018
TI  - Comparison of Multiple Treatment Planning Techniques for High-Grade Glioma Tumors 
      Near to Critical Organs.
PG  - 514-519
LID - 10.1159/000487642 [doi]
AB  - AIM: The purpose of this study was to compare 6 treatment planning methods 
      (5-beam coplanar intensity-modulated radiotherapy (IMRT), 7-beam coplanar IMRT, 
      7-beam noncoplanar IMRT, 2 full arc coplanar volumetric modulated arc therapy 
      (VMAT), 2 half partial arc coplanar VMAT, and 2 half partial arc noncoplanar 
      VMAT) for high-grade gliomas with planning target volumes (PTVs) overlapping the 
      optic pathway and/or brainstem. PATIENTS AND METHODS: 27 previously-treated 
      patients with high-grade gliomas were replanned for treatment with IMRT5, IMRT7, 
      IMRT7-non, VMAT2f, VMAT2h, and VMAT2h-non. In order to perform a comparative 
      study of the treatment outcomes, 3 tumor localizations (right-sided, left-sided, 
      and central tumors) were selected. Patients were administered a PTV dose of 60 Gy 
      in 30 fractions with a maximum permitted dose of 110%. RESULTS: Comparison of the 
      3 IMRT plans and 3 VMAT plans was performed for all 27 patients. The median 
      conformity index was significantly higher (p < 0.05) in all IMRT plans compared 
      to all VMAT plans in the case of right sided tumors. Significant differences were 
      also observed between coplanar and noncoplanar plans in IMRT and VMAT in 
      right-sided tumors (p < 0.05). Differences in brainstem mean doses were only 
      found to be significant between coplanar and noncoplanar plans in 
      centrally-located tumors. In right- and left-sided tumors, the VMAT2f plans 
      demonstrated higher values than all IMRT plans in their mean values for radiation 
      doses to the ipsilateral optic nerves, contralateral optic nerves, ipsilateral 
      lens, ipsilateral eye, contralateral lens, contralateral eye, and contralateral 
      optic nerves, as well in the maximums for the optic chiasm and contralateral 
      optic nerves. Significantly faster treatment times were achieved with all VMAT 
      plans compared to IMRT plans. CONCLUSION: IMRT techniques provided better target 
      coverage than VMAT plans. However, VMAT techniques reduced treatment delivery 
      time more than IMRT techniques. Technique selection for tumors located in 3 
      different localizations should be individualized in accordance with patients' 
      specific parameters.
CI  - (c) 2018 S. Karger GmbH, Freiburg.
FAU - Bas Ayata, Hande
AU  - Bas Ayata H
FAU - Ceylan, Cemile
AU  - Ceylan C
FAU - Kilic, Ayhan
AU  - Kilic A
FAU - Guden, Metin
AU  - Guden M
FAU - Engin, Kayihan
AU  - Engin K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180808
PL  - Switzerland
TA  - Oncol Res Treat
JT  - Oncology research and treatment
JID - 101627692
SB  - IM
MH  - Brain/diagnostic imaging/pathology/radiation effects
MH  - Brain Neoplasms/diagnostic imaging/pathology/*radiotherapy
MH  - Glioma/diagnostic imaging/pathology/*radiotherapy
MH  - Humans
MH  - Neoplasm Grading
MH  - Organs at Risk/diagnostic imaging/radiation effects
MH  - Radiation Injuries/etiology/*prevention & control
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/adverse effects/*methods
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - High-grade glioma
OT  - IMRT
OT  - Noncoplanar
OT  - VMAT
EDAT- 2018/08/08 06:00
MHDA- 2019/09/04 06:00
CRDT- 2018/08/08 06:00
PHST- 2017/04/27 00:00 [received]
PHST- 2018/02/13 00:00 [accepted]
PHST- 2018/08/08 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2018/08/08 06:00 [entrez]
AID - 000487642 [pii]
AID - 10.1159/000487642 [doi]
PST - ppublish
SO  - Oncol Res Treat. 2018;41(9):514-519. doi: 10.1159/000487642. Epub 2018 Aug 8.