PMID- 30086859
OWN - NLM
STAT- MEDLINE
DCOM- 20190827
LR  - 20190827
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 73
IP  - 11
DP  - 2018 Nov
TI  - Prognostic value of late gadolinium enhancement on CMR in patients with severe 
      aortic valve disease: a systematic review and meta-analysis.
PG  - 983.e7-983.e14
LID - S0009-9260(18)30365-9 [pii]
LID - 10.1016/j.crad.2018.07.095 [doi]
AB  - AIM: To evaluate the predictive value of late gadolinium enhancement (LGE) on 
      cardiac magnetic resonance (CMR) in patients with severe aortic valve disease. 
      MATERIALS AND METHODS: PubMed, EMBASE, and Web of Science were searched for 
      studies applying LGE-CMR to assess prognostic significance in patients with 
      severe aortic valve disease and to measure myocardial fibrosis (MF). The 
      association of LGE with outcomes was estimated for each study by an odds ratio 
      (OR) along with its 95% confidence interval (CI). Pooled estimates of ORs were 
      calculated using a Mantel-Haenszel fixed-effects model. RESULTS: Six studies 
      including 626 patients were included in the meta-analysis. The follow-up period 
      was from 0.5 to 5.7 years. The pooled OR was 3.28 (95% CI: 2.02-5.32; p<0.001) 
      for LGE (+) versus LGE (-) in predicting patients with aortic valve disease in 
      all-cause mortality. The presence of LGE was associated with cardiovascular 
      mortality (pooled OR: 3.10, 95% CI: 1.73-5.56; p<0.001). The presence of LGE was 
      associated with all-cause mortality in patients with severe aortic stenosis after 
      aortic valve replacement (pooled OR: 2.30, 95% CI: 1.06-4.99; p=0.036). 
      CONCLUSION: LGE on CMR is a promising risk stratification method, as it could 
      predict all-cause mortality and cardiovascular mortality in patients with aortic 
      valve disease, especially for aortic stenosis. LGE-CMR also has significant 
      prognostic value in patients after aortic valve replacement.
CI  - Copyright (c) 2018 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Chen, H
AU  - Chen H
AD  - Department of Radiology, The Yongchuan Affiliated Hospital, Chongqing Medical 
      University, Xuan hua Road, 402160, Yongchuan District, Chongqing, PR China.
FAU - Zeng, J
AU  - Zeng J
AD  - Department of Radiology, The Yongchuan Affiliated Hospital, Chongqing Medical 
      University, Xuan hua Road, 402160, Yongchuan District, Chongqing, PR China.
FAU - Liu, D
AU  - Liu D
AD  - Department of Radiology, The Yongchuan Affiliated Hospital, Chongqing Medical 
      University, Xuan hua Road, 402160, Yongchuan District, Chongqing, PR China.
FAU - Yang, Q
AU  - Yang Q
AD  - Department of Radiology, The Yongchuan Affiliated Hospital, Chongqing Medical 
      University, Xuan hua Road, 402160, Yongchuan District, Chongqing, PR China. 
      Electronic address: flyingfish0331@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20180804
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aortic Valve/*diagnostic imaging
MH  - Aortic Valve Insufficiency/diagnosis/diagnostic imaging/mortality
MH  - Aortic Valve Stenosis/diagnosis/*diagnostic imaging/mortality
MH  - Cardiovascular Diseases/mortality
MH  - *Contrast Media
MH  - *Gadolinium
MH  - Humans
MH  - *Magnetic Resonance Imaging/methods
MH  - Prognosis
EDAT- 2018/08/09 06:00
MHDA- 2019/08/28 06:00
CRDT- 2018/08/09 06:00
PHST- 2018/03/19 00:00 [received]
PHST- 2018/07/04 00:00 [accepted]
PHST- 2018/08/09 06:00 [pubmed]
PHST- 2019/08/28 06:00 [medline]
PHST- 2018/08/09 06:00 [entrez]
AID - S0009-9260(18)30365-9 [pii]
AID - 10.1016/j.crad.2018.07.095 [doi]
PST - ppublish
SO  - Clin Radiol. 2018 Nov;73(11):983.e7-983.e14. doi: 10.1016/j.crad.2018.07.095. 
      Epub 2018 Aug 4.