PMID- 30088367
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 10
IP  - 5
DP  - 2018 Sep
TI  - Prevalence, Risk Factors and Cutoff Values for Bronchial Hyperresponsiveness to 
      Provocholine in 7-Year-Old Children.
PG  - 466-477
LID - 10.4168/aair.2018.10.5.466 [doi]
AB  - BACKGROUND: A US Food and Drug Administration (FDA)-approved drug methacholine 
      chloride (Provocholine(R)) was recently introduced to Korea where it is now widely 
      used in clinical practice. We aimed to evaluate the prevalence, risk factors and 
      cutoff value of bronchial hyperresponsiveness (BHR) to Provocholine in 7-year-old 
      children. METHODS: Six hundred and thirty-three children from the Panel Study on 
      Korean Children who visited 16 regional hospitals were evaluated. Skin prick 
      tests, spirometry and bronchial provocation tests for Provocholine as well as a 
      detailed history and physical examinations were performed. The bronchial 
      provocation test was reliably performed on 559 of these children. RESULTS: The 
      prevalence of ever-diagnosed asthma via medical records was 7.7%, and that of 
      current asthma (wheezy episode in the last 12 months + diagnosed asthma by 
      physicians) was 3.2%. The prevalence of BHR to Provocholine was 17.2% and 25.8%, 
      respectively, for a PC20 < 8 and < 16 mg/mL. The risk factors for BHR (PC20 < 16 
      mg/mL) were atopic dermatitis diagnosis and current dog ownership, whereas those 
      for current asthma were allergy rhinitis diagnosis, a history of bronchiolitis 
      before the age of 3, recent use of analgesics/antipyretics and maternal history 
      of asthma. The BHR prevalence trend showed an increase along with the increased 
      immunoglobulin E (IgE) quartile. The cutoff value of PC20 for the diagnosis of 
      current asthma in children at age 7 was 5.8 mg/mL (sensitivity: 47.1%, 
      specificity: 87.4%). CONCLUSIONS: BHR to Provocholine (PC20 < 8 mg/mL) was 
      observed in 17.2% of 7-year-olds children from the general population and the 
      cutoff value of PC20 for the diagnosis of current asthma was 5.8 mg/mL in this 
      age group. The risk factors for BHR and current asthma showed discrepancies 
      suggesting different underlying mechanisms. Bronchial provocation testing with 
      Provocholine will be a useful clinical tool in the future.
CI  - Copyright (c) 2018 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Jung, Sungsu
AU  - Jung S
AUID- ORCID: 0000-0002-0559-4982
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 
      Korea.
FAU - Suh, Dong In
AU  - Suh DI
AUID- ORCID: 0000-0002-7817-8728
AD  - Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.
FAU - Lee, So Yeon
AU  - Lee SY
AUID- ORCID: 0000-0002-2499-0702
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 
      Korea.
FAU - Yoon, Jisun
AU  - Yoon J
AUID- ORCID: 0000-0002-4904-9118
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 
      Korea.
FAU - Cho, Hyun Ju
AU  - Cho HJ
AUID- ORCID: 0000-0003-4282-4000
AD  - Department of Pediatrics, International St. Mary's Hospital, Catholic Kwandong 
      University Hospital, Incheon, Korea.
FAU - Kim, Young Ho
AU  - Kim YH
AUID- ORCID: 0000-0001-7120-8130
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 
      Korea.
FAU - Yang, Song I
AU  - Yang SI
AUID- ORCID: 0000-0002-9648-4585
AD  - Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, Korea.
FAU - Kwon, Ji Won
AU  - Kwon JW
AUID- ORCID: 0000-0002-5129-928X
AD  - Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, 
      Korea.
FAU - Jang, Gwang Cheon
AU  - Jang GC
AD  - Department of Pediatrics, National Health Insurance Service Ilsan Hospital, 
      Goyang, Korea.
FAU - Sun, Yong Han
AU  - Sun YH
AUID- ORCID: 0000-0003-1527-6782
AD  - Department of Pediatrics, Gachon University Gil Medical Center, Incheon, Korea.
FAU - Woo, Sung Il
AU  - Woo SI
AUID- ORCID: 0000-0003-1896-6279
AD  - Department of Pediatrics, College of Medicine, Chungbuk National University, 
      Cheongju, Korea.
FAU - Youn, You Sook
AU  - Youn YS
AD  - Department of Pediatrics, The Catholic University of Korea College of Medicine, 
      Daejeon, Korea.
FAU - Park, Kang Seo
AU  - Park KS
AUID- ORCID: 0000-0003-3983-9770
AD  - Department of Pediatrics, Presbyterian Medical Center, Jeonju, Korea.
FAU - Cho, Hwa Jin
AU  - Cho HJ
AUID- ORCID: 0000-0002-2458-8529
AD  - Department of Pediatrics, Chonnam National University Hospital, Chonnam National 
      University Medical School, Gwangju, Korea.
FAU - Kook, Myung Hee
AU  - Kook MH
AD  - Department of Pediatrics, Gwangju Veterans Hospital, Gwangju, Korea.
FAU - Yi, Hye Ryoung
AU  - Yi HR
AD  - Department of Pediatrics, Gwangju Veterans Hospital, Gwangju, Korea.
FAU - Chung, Hai Lee
AU  - Chung HL
AUID- ORCID: 0000-0002-5364-5318
AD  - Department of Pediatrics, Catholic University of Daegu School of Medicine, Daegu, 
      Korea.
FAU - Kim, Ja Hyeong
AU  - Kim JH
AUID- ORCID: 0000-0003-0691-1924
AD  - Department of Pediatrics, Ulsan University Hospital, Ulsan, Korea.
FAU - Kim, Hyung Young
AU  - Kim HY
AUID- ORCID: 0000-0001-8591-1783
AD  - Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, 
      Korea.
FAU - Jung, Jin A
AU  - Jung JA
AD  - Department of Pediatrics, Dong-A University College of Medicine, Busan, Korea.
FAU - Woo, Hyang Ok
AU  - Woo HO
AUID- ORCID: 0000-0001-8849-9341
AD  - Department of Pediatrics, Health Science Institute, Gyeongsang National 
      University College of Medicine, Jinju, Korea.
FAU - Hong, Soo Jong
AU  - Hong SJ
AUID- ORCID: 0000-0003-1409-2113
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 
      Korea. sjhong@amc.seoul.kr.
LA  - eng
GR  - 2015-ER6601-00/Korea Centers for Disease Control & Prevention/
GR  - Korea Institute of Child Care and Education/
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC6082814
OTO - NOTNLM
OT  - Bronchial hyperreactivity
OT  - ROC curve
OT  - asthma
OT  - prevalence
OT  - risk factors
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2018/08/09 06:00
MHDA- 2018/08/09 06:01
PMCR- 2018/09/01
CRDT- 2018/08/09 06:00
PHST- 2017/12/07 00:00 [received]
PHST- 2018/03/30 00:00 [revised]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/08/09 06:00 [entrez]
PHST- 2018/08/09 06:00 [pubmed]
PHST- 2018/08/09 06:01 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
AID - 10.466 [pii]
AID - 10.4168/aair.2018.10.5.466 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2018 Sep;10(5):466-477. doi: 
      10.4168/aair.2018.10.5.466.