PMID- 30089265
OWN - NLM
STAT- MEDLINE
DCOM- 20200127
LR  - 20210109
IS  - 2211-1247 (Electronic)
VI  - 24
IP  - 6
DP  - 2018 Aug 7
TI  - Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in 
      Synaptic Efficacy of CA3-CA1 Synapses.
PG  - 1550-1561
LID - S2211-1247(18)31110-0 [pii]
LID - 10.1016/j.celrep.2018.07.020 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, 
      tropomyosin receptor kinase B (TrkB), regulate long-term potentiation (LTP) in 
      the hippocampus, although the sites of BDNF-TrkB receptors in this process are 
      controversial. We used a viral-mediated approach to delete BDNF or TrkB 
      specifically in CA1 and CA3 regions of the Schaffer collateral pathway. Deletion 
      of BDNF in CA3 or CA1 revealed that presynaptic BDNF is involved in LTP 
      induction, while postsynaptic BDNF contributes to LTP maintenance. Similarly, 
      loss of presynaptic or postsynaptic TrkB receptors leads to distinct LTP 
      deficits, with presynaptic TrkB required to maintain LTP, while postsynaptic TrkB 
      is essential for LTP formation. In addition, loss of TrkB in CA3 significantly 
      diminishes release probability, uncovering a role for presynaptic TrkB receptors 
      in basal neurotransmission. Taken together, this direct comparison of presynaptic 
      and postsynaptic BDNF-TrkB reveals insight into BDNF release and TrkB activation 
      sites in hippocampal LTP.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Lin, Pei-Yi
AU  - Lin PY
AD  - Department of Neuroscience, The University of Texas Southwestern Medical Center, 
      Dallas, TX 75390-9111, USA.
FAU - Kavalali, Ege T
AU  - Kavalali ET
AD  - Department of Neuroscience, The University of Texas Southwestern Medical Center, 
      Dallas, TX 75390-9111, USA.
FAU - Monteggia, Lisa M
AU  - Monteggia LM
AD  - Department of Neuroscience, The University of Texas Southwestern Medical Center, 
      Dallas, TX 75390-9111, USA. Electronic address: 
      lisa.monteggia@utsouthwestern.edu.
LA  - eng
GR  - R01 MH066198/MH/NIMH NIH HHS/United States
GR  - R01 MH070727/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (Receptors, Presynaptic)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mice
MH  - Receptor, trkB/*metabolism
MH  - Receptors, Presynaptic/*genetics
MH  - Signal Transduction
MH  - Synapses/*metabolism
MH  - Synaptic Potentials/*genetics
PMC - PMC7176480
MID - NIHMS1563805
OTO - NOTNLM
OT  - BDNF
OT  - LTP
OT  - TrkB
OT  - hippocampus
OT  - postsynaptic
OT  - presynaptic
OT  - synaptic plasticity
EDAT- 2018/08/09 06:00
MHDA- 2020/01/28 06:00
PMCR- 2020/04/22
CRDT- 2018/08/09 06:00
PHST- 2017/12/27 00:00 [received]
PHST- 2018/05/31 00:00 [revised]
PHST- 2018/07/05 00:00 [accepted]
PHST- 2018/08/09 06:00 [entrez]
PHST- 2018/08/09 06:00 [pubmed]
PHST- 2020/01/28 06:00 [medline]
PHST- 2020/04/22 00:00 [pmc-release]
AID - S2211-1247(18)31110-0 [pii]
AID - 10.1016/j.celrep.2018.07.020 [doi]
PST - ppublish
SO  - Cell Rep. 2018 Aug 7;24(6):1550-1561. doi: 10.1016/j.celrep.2018.07.020.