PMID- 30089986
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 0974-7796 (Print)
IS  - 0974-7834 (Electronic)
IS  - 0974-7796 (Linking)
VI  - 10
IP  - 3
DP  - 2018 Jul-Sep
TI  - Clinical and biochemical markers of visceral adipose tissue activity: Body mass 
      index, visceral adiposity index, leptin, adiponectin, and matrix 
      metalloproteinase-3. Correlation with Gleason patterns 4 and 5 at prostate 
      biopsy.
PG  - 280-286
LID - 10.4103/UA.UA_188_17 [doi]
AB  - CONTEXT: The correlation between aggressive prostate cancer and obesity mainly 
      based on body mass index (BMI) and pathology after surgery remains controversial. 
      AIMS: The aim of the study was to correlate BMI, visceral adiposity index (VAI), 
      and the plasmatic levels of leptin, adiponectin, and matrix metalloproteinase-3 
      (MMP-3), and biomarkers of adipose tissue function, with the detection of Gleason 
      patterns 4 and 5 at biopsy. SUBJECTS AND METHODS: Consecutive patients with 
      prostate cancer at 12-core transrectal biopsy were enrolled. BMI, waist 
      circumference (WC), blood samples to evaluate the plasmatic levels of 
      triglycerides (TG) and high-density lipoproteins (HDL), adiponectin, leptin, and 
      MMP-3 were obtained immediately before biopsy. The VAI was calculated according 
      to the formula: WC/(39.68 + [1.88 x BMI]) x TG/1.03 x 1.31/HDL. RESULTS: One 
      hundred and forty-nine patients were entered. The median PSA, BMI, and VAI were 
      10.0 ng/ml, 27.6 kg/m(2), and 4.6, respectively. Gleason patterns 4 or 5 were 
      detected in 68 (45.6%) patients; in 15 (41.7%), 31 (44.9%), and 22 (50.0%) among 
      normal weight, overweight, and obese patients, respectively (P = 0.55). The 
      statistical analysis did not show any significant correlation between BMI, VAI, 
      the plasmatic levels of leptin, adiponectin, MMP-3, and the detection of Gleason 
      patterns 4 and 5 at biopsy. A statistically significant association emerged with 
      older age (P = 0.017) and higher PSA values (P = 0.02). CONCLUSION: We did not 
      find any association between BMI, VAI, the plasmatic levels of adiponectin, 
      leptin, and MMP-3 and the detection of Gleason patterns 4 and 5 at prostate 
      biopsy.
FAU - Serretta, Vincenzo
AU  - Serretta V
AD  - Department of Surgical, Oncological and Stomatological Sciences, University of 
      Palermo, Palermo, Italy.
FAU - Abrate, Alberto
AU  - Abrate A
AD  - Department of Surgical, Oncological and Stomatological Sciences, University of 
      Palermo, Palermo, Italy.
FAU - Siracusano, Simone
AU  - Siracusano S
AD  - Department of Surgical, Oncological and Stomatological Sciences, University of 
      Palermo, Palermo, Italy.
FAU - Gesolfo, Cristina Scalici
AU  - Gesolfo CS
AD  - Department of Surgical, Oncological and Stomatological Sciences, University of 
      Palermo, Palermo, Italy.
FAU - Vella, Marco
AU  - Vella M
AD  - Department of Surgical, Oncological and Stomatological Sciences, University of 
      Palermo, Palermo, Italy.
FAU - Di Maida, Fabrizio
AU  - Di Maida F
AD  - Department of Surgical, Oncological and Stomatological Sciences, University of 
      Palermo, Palermo, Italy.
FAU - Cangemi, Antonina
AU  - Cangemi A
AD  - Department of Surgical, Oncological and Stomatological Sciences, University of 
      Palermo, Palermo, Italy.
FAU - Cicero, Giuseppe
AU  - Cicero G
AD  - Department of Surgical, Oncological and Stomatological Sciences, University of 
      Palermo, Palermo, Italy.
FAU - Barresi, Elisabetta
AU  - Barresi E
AD  - Department of Human Pathology, University of Palermo, Palermo, Italy.
FAU - Sanfilippo, Chiara
AU  - Sanfilippo C
AD  - Stastistics, GSTU Foundation, Palermo, Italy.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Urol Ann
JT  - Urology annals
JID - 101510823
PMC - PMC6060586
OTO - NOTNLM
OT  - Adiponectin
OT  - Gleason pattern
OT  - body mass index
OT  - leptin
OT  - matrix metalloproteinase-3
OT  - obesity
OT  - prostate cancer
OT  - visceral adiposity index
COIS- There are no conflicts of interest.
EDAT- 2018/08/10 06:00
MHDA- 2018/08/10 06:01
PMCR- 2018/07/01
CRDT- 2018/08/10 06:00
PHST- 2018/08/10 06:00 [entrez]
PHST- 2018/08/10 06:00 [pubmed]
PHST- 2018/08/10 06:01 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - UA-10-280 [pii]
AID - 10.4103/UA.UA_188_17 [doi]
PST - ppublish
SO  - Urol Ann. 2018 Jul-Sep;10(3):280-286. doi: 10.4103/UA.UA_188_17.