PMID- 30090444
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230926
IS  - 2045-452X (Print)
IS  - 2045-4538 (Electronic)
IS  - 2045-452X (Linking)
VI  - 5
IP  - 5
DP  - 2016 Sep 1
TI  - Epigenetic disruption and glucose homeostasis changes following low-dose maternal 
      bisphenol A exposure.
PG  - 1400-1409
LID - 10.1039/c6tx00047a [doi]
AB  - Developmental exposure to bisphenol A (BPA) has been linked to impaired glucose 
      homeostasis and pancreatic function in adulthood, which has been hypothesized to 
      result from the disruption of pancreatic beta-cell development at early life. Here 
      we evaluated whether maternal BPA exposure disrupts beta-cell development and 
      glucose tolerance and the role of epigenetic modifications of key regulator in 
      this process. We found that maternal exposure to BPA (10 mug kg(-1) d(-1)) reduced 
      the pancreatic beta-cell mass and the expression of pancreatic and duodenal homeobox 
      1 (Pdx1) at birth, as well as the expression of Pdx1 at gestational day (GD) 
      15.5. In parallel with the decreased expression of Pdx1, histones H3 and H4 
      deacetylation, along with demethylation of histone 3 lysine 4 (H3K4) and 
      methylation of histone 3 lysine 9 (H3K9), were found at the promoter of Pdx1, 
      while no significant changes in DNA methylation status were detected at this 
      region. Moreover, these alterations were observed in adult life along with 
      impaired glucose tolerance. We conclude that maternal exposure to BPA reduces 
      pancreatic beta-cell mass at birth by reducing PDX1(+) progenitors during fetal 
      development through altering the histone modifications of Pdx1, which can be 
      propagated to later life and increase the susceptibility to glucose intolerance.
FAU - Chang, Huailong
AU  - Chang H
AD  - Key Laboratory of Environment and Health , Ministry of Education & Ministry of 
      Environmental Protection , and State Key Laboratory of Environmental Health 
      (incubating) , School of Public Health , Tongji Medical College , Huazhong 
      University of Science and Technology , Wuhan 430030 , China . Email: 
      liyuanyuan@hsut.edu.cn ; Email: xust@hust.edu.cn ; ; Tel: +86-27-83693417, 
      86-27-83657705.
FAU - Wang, Danqi
AU  - Wang D
AD  - School of Public Health , Changsha Medical University , Changsha 410219 , China.
FAU - Xia, Wei
AU  - Xia W
AD  - Key Laboratory of Environment and Health , Ministry of Education & Ministry of 
      Environmental Protection , and State Key Laboratory of Environmental Health 
      (incubating) , School of Public Health , Tongji Medical College , Huazhong 
      University of Science and Technology , Wuhan 430030 , China . Email: 
      liyuanyuan@hsut.edu.cn ; Email: xust@hust.edu.cn ; ; Tel: +86-27-83693417, 
      86-27-83657705.
FAU - Pan, Xinyun
AU  - Pan X
AD  - Key Laboratory of Environment and Health , Ministry of Education & Ministry of 
      Environmental Protection , and State Key Laboratory of Environmental Health 
      (incubating) , School of Public Health , Tongji Medical College , Huazhong 
      University of Science and Technology , Wuhan 430030 , China . Email: 
      liyuanyuan@hsut.edu.cn ; Email: xust@hust.edu.cn ; ; Tel: +86-27-83693417, 
      86-27-83657705.
FAU - Huo, Wenqian
AU  - Huo W
AD  - Key Laboratory of Environment and Health , Ministry of Education & Ministry of 
      Environmental Protection , and State Key Laboratory of Environmental Health 
      (incubating) , School of Public Health , Tongji Medical College , Huazhong 
      University of Science and Technology , Wuhan 430030 , China . Email: 
      liyuanyuan@hsut.edu.cn ; Email: xust@hust.edu.cn ; ; Tel: +86-27-83693417, 
      86-27-83657705.
FAU - Xu, Shunqing
AU  - Xu S
AD  - Key Laboratory of Environment and Health , Ministry of Education & Ministry of 
      Environmental Protection , and State Key Laboratory of Environmental Health 
      (incubating) , School of Public Health , Tongji Medical College , Huazhong 
      University of Science and Technology , Wuhan 430030 , China . Email: 
      liyuanyuan@hsut.edu.cn ; Email: xust@hust.edu.cn ; ; Tel: +86-27-83693417, 
      86-27-83657705.
FAU - Li, Yuanyuan
AU  - Li Y
AD  - Key Laboratory of Environment and Health , Ministry of Education & Ministry of 
      Environmental Protection , and State Key Laboratory of Environmental Health 
      (incubating) , School of Public Health , Tongji Medical College , Huazhong 
      University of Science and Technology , Wuhan 430030 , China . Email: 
      liyuanyuan@hsut.edu.cn ; Email: xust@hust.edu.cn ; ; Tel: +86-27-83693417, 
      86-27-83657705.
LA  - eng
PT  - Journal Article
DEP - 20160620
PL  - England
TA  - Toxicol Res (Camb)
JT  - Toxicology research
JID - 101587950
PMC - PMC6061978
EDAT- 2016/06/20 00:00
MHDA- 2016/06/20 00:01
PMCR- 2017/06/20
CRDT- 2018/08/10 06:00
PHST- 2016/01/29 00:00 [received]
PHST- 2016/06/19 00:00 [accepted]
PHST- 2018/08/10 06:00 [entrez]
PHST- 2016/06/20 00:00 [pubmed]
PHST- 2016/06/20 00:01 [medline]
PHST- 2017/06/20 00:00 [pmc-release]
AID - c6tx00047a [pii]
AID - 10.1039/c6tx00047a [doi]
PST - epublish
SO  - Toxicol Res (Camb). 2016 Jun 20;5(5):1400-1409. doi: 10.1039/c6tx00047a. 
      eCollection 2016 Sep 1.