PMID- 30090490
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2045-452X (Print)
IS  - 2045-4538 (Electronic)
IS  - 2045-452X (Linking)
VI  - 6
IP  - 2
DP  - 2017 Mar 1
TI  - Cystamine attenuated behavioral deficiency via increasing the expression of BDNF 
      and activating PI3K/Akt signaling in 2,5-hexanedione intoxicated rats.
PG  - 199-204
LID - 10.1039/c6tx00409a [doi]
AB  - Organic solvent-induced neurodegeneration is a severe public health problem which 
      has no effective prevention measures yet. Cystamine stands as a promising 
      neuroprotective agent against many degenerative diseases. In the present study, 
      we investigated the possible protective effects of cystamine against 
      2,5-hexanedione (2,5-HD) induced peripheral neuropathy. Chronic exposure to 
      2,5-HD (300 mg kg(-1), 6 times per week for 6 weeks) resulted in obvious 
      peripheral nerve damage shown as the elevation of gait scores and the increase of 
      latency in an accelerating rota-rod test. Cystamine (30 mg kg(-1) and 60 mg 
      kg(-1)) co-treatment obviously ameliorated 2,5-HD-induced impairments of the 
      peripheral nervous system. To decipher the underlying mechanisms, we investigated 
      the effects of cystamine on the regulation of brain-derived neurotrophic factor 
      (BDNF) and heat shock protein-70 (Hsp70) expression and the PI3K/Akt signaling 
      pathway. The results revealed that cystamine up-regulated the protein levels of 
      BDNF and Hsp70, accompanied by the activation of the PI3K/Akt pathway in the 
      spinal cord, which might account for the protection of cystamine against 
      2,5-HD-induced neuropathy.
FAU - Wang, Shuo
AU  - Wang S
AD  - Institute of Toxicology , School of Public Health , Shandong University , Jinan , 
      Shandong 250012 , China . Email: keqinx@sdu.edu.cn ; Tel: +86-531-88382132.
FAU - Li, Xianjie
AU  - Li X
AD  - Institute of Toxicology , School of Public Health , Shandong University , Jinan , 
      Shandong 250012 , China . Email: keqinx@sdu.edu.cn ; Tel: +86-531-88382132.
FAU - Li, Ming
AU  - Li M
AD  - Institute of Toxicology , School of Public Health , Shandong University , Jinan , 
      Shandong 250012 , China . Email: keqinx@sdu.edu.cn ; Tel: +86-531-88382132.
FAU - Jiang, Lulu
AU  - Jiang L
AD  - Institute of Toxicology , School of Public Health , Shandong University , Jinan , 
      Shandong 250012 , China . Email: keqinx@sdu.edu.cn ; Tel: +86-531-88382132.
FAU - Yuan, Hua
AU  - Yuan H
AD  - The People's Hospital of Shouguang , Weifang , Shandong 262700 , China.
FAU - Han, Wenting
AU  - Han W
AD  - Institute of Toxicology , School of Public Health , Shandong University , Jinan , 
      Shandong 250012 , China . Email: keqinx@sdu.edu.cn ; Tel: +86-531-88382132.
FAU - Wang, Xujing
AU  - Wang X
AD  - Institute of Toxicology , School of Public Health , Shandong University , Jinan , 
      Shandong 250012 , China . Email: keqinx@sdu.edu.cn ; Tel: +86-531-88382132.
FAU - Zeng, Tao
AU  - Zeng T
AD  - Institute of Toxicology , School of Public Health , Shandong University , Jinan , 
      Shandong 250012 , China . Email: keqinx@sdu.edu.cn ; Tel: +86-531-88382132.
FAU - Xie, Keqin
AU  - Xie K
AUID- ORCID: 0000-0001-9634-5983
AD  - Institute of Toxicology , School of Public Health , Shandong University , Jinan , 
      Shandong 250012 , China . Email: keqinx@sdu.edu.cn ; Tel: +86-531-88382132.
LA  - eng
PT  - Journal Article
DEP - 20161212
PL  - England
TA  - Toxicol Res (Camb)
JT  - Toxicology research
JID - 101587950
PMC - PMC6062339
EDAT- 2016/12/12 00:00
MHDA- 2016/12/12 00:01
PMCR- 2017/12/12
CRDT- 2018/08/10 06:00
PHST- 2016/11/02 00:00 [received]
PHST- 2016/12/09 00:00 [accepted]
PHST- 2018/08/10 06:00 [entrez]
PHST- 2016/12/12 00:00 [pubmed]
PHST- 2016/12/12 00:01 [medline]
PHST- 2017/12/12 00:00 [pmc-release]
AID - c6tx00409a [pii]
AID - 10.1039/c6tx00409a [doi]
PST - epublish
SO  - Toxicol Res (Camb). 2016 Dec 12;6(2):199-204. doi: 10.1039/c6tx00409a. 
      eCollection 2017 Mar 1.