PMID- 30090556
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230926
IS  - 2045-452X (Print)
IS  - 2045-4538 (Electronic)
IS  - 2045-452X (Linking)
VI  - 6
IP  - 6
DP  - 2017 Nov 1
TI  - Evaluation of the toxicity of iron-ion irradiation in murine bone marrow 
      dendritic cells via increasing the expression of indoleamine 2,3-dioxygenase 1.
PG  - 958-968
LID - 10.1039/c7tx00194k [doi]
AB  - High linear energy transfer radiation is known to deposit higher energy in 
      tissues and cause greater toxicity compared to low-LET irradiation. Local 
      immunosuppression is frequently observed after irradiation (IR). Dendritic cells 
      (DCs) play important roles in the initiation and maintenance of the immune 
      response. The dysfunction of DCs contributes to tumor evasion and growth. 
      However, molecular mechanisms underlying the establishment of immune tolerance 
      induced by heavy ion IR through this DC population are poorly understood. 
      Therefore, here we report our findings on the dysfunction of bone marrow-derived 
      dendritic cells (BMDCs) induced by 1 Gy iron ion radiation and promotions of 
      expressions of JNK1/2/3, indoleamine 2,3-dioxygenase 1 (IDO1), p-ERK1/2 and 
      p38/MAPK; and decrease of IDO2, MHC class II, CD40, CD80 expressions and IFN-gamma 
      and TNF-alpha secretion after total-body IR in mice. JNK(+)IDO1(+) BMDCs showed 
      up-expression of p-ERK1/2 and p-p38/MAPK, reduced expression of MHC class II and 
      CD80, and were not able to effectively stimulate allogeneic spleen T cells. The 
      inhibition of IDO1 expressions could partly restore the function of BMDCs. In 
      all, our study shows that elevated JNK and IDO1 expression induced by Fe ion IR 
      could result in dysfunction of BMDCs via p-p38/MAPK and p-ERK1/2 signal pathway, 
      and it may represent a new mechanism in radiation-induced immune tolerance.
FAU - Xie, Yi
AU  - Xie Y
AD  - Institute of Modern Physics , Chinese Academy of Sciences , 509 Nanchang Road , 
      Lanzhou 730000 , China . Email: zhangh@impcas.ac.cn ; ; Tel: +86 931 4969344.
AD  - CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine , Institute of 
      Modern Physics , Lanzhou 730000 , Gansu , China.
AD  - Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine , 
      Gansu Province , Lanzhou 730000 , China.
FAU - Yan, Jun-Fang
AU  - Yan JF
AD  - Institute of Modern Physics , Chinese Academy of Sciences , 509 Nanchang Road , 
      Lanzhou 730000 , China . Email: zhangh@impcas.ac.cn ; ; Tel: +86 931 4969344.
AD  - CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine , Institute of 
      Modern Physics , Lanzhou 730000 , Gansu , China.
AD  - Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine , 
      Gansu Province , Lanzhou 730000 , China.
AD  - Graduate School of University of Chinese Academy of Sciences , Beijing 100039 , 
      China.
FAU - Ma, Jing-Yi
AU  - Ma JY
AD  - School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , 
      China.
FAU - Li, Hong-Yan
AU  - Li HY
AD  - Institute of Modern Physics , Chinese Academy of Sciences , 509 Nanchang Road , 
      Lanzhou 730000 , China . Email: zhangh@impcas.ac.cn ; ; Tel: +86 931 4969344.
AD  - CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine , Institute of 
      Modern Physics , Lanzhou 730000 , Gansu , China.
AD  - Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine , 
      Gansu Province , Lanzhou 730000 , China.
FAU - Ye, Yan-Cheng
AU  - Ye YC
AD  - Gansu Wuwei Tumor Hospital , Wuwei , 733000 , China.
FAU - Zhang, Yan-Shan
AU  - Zhang YS
AD  - Gansu Wuwei Tumor Hospital , Wuwei , 733000 , China.
FAU - Zhang, Hong
AU  - Zhang H
AUID- ORCID: 0000-0002-1790-6314
AD  - Institute of Modern Physics , Chinese Academy of Sciences , 509 Nanchang Road , 
      Lanzhou 730000 , China . Email: zhangh@impcas.ac.cn ; ; Tel: +86 931 4969344.
AD  - CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine , Institute of 
      Modern Physics , Lanzhou 730000 , Gansu , China.
AD  - Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine , 
      Gansu Province , Lanzhou 730000 , China.
AD  - Gansu Wuwei Tumor Hospital , Wuwei , 733000 , China.
LA  - eng
PT  - Journal Article
DEP - 20170925
PL  - England
TA  - Toxicol Res (Camb)
JT  - Toxicology research
JID - 101587950
PMC - PMC6061850
EDAT- 2018/08/10 06:00
MHDA- 2018/08/10 06:01
PMCR- 2018/09/25
CRDT- 2018/08/10 06:00
PHST- 2017/07/13 00:00 [received]
PHST- 2017/09/24 00:00 [accepted]
PHST- 2018/08/10 06:00 [entrez]
PHST- 2018/08/10 06:00 [pubmed]
PHST- 2018/08/10 06:01 [medline]
PHST- 2018/09/25 00:00 [pmc-release]
AID - c7tx00194k [pii]
AID - 10.1039/c7tx00194k [doi]
PST - epublish
SO  - Toxicol Res (Camb). 2017 Sep 25;6(6):958-968. doi: 10.1039/c7tx00194k. 
      eCollection 2017 Nov 1.