PMID- 30090583
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2045-452X (Print)
IS  - 2045-4538 (Electronic)
IS  - 2045-452X (Linking)
VI  - 7
IP  - 2
DP  - 2018 Mar 1
TI  - Prenatal food restriction induces neurobehavioral abnormalities in adult female 
      offspring rats and alters intrauterine programming.
PG  - 293-306
LID - 10.1039/c7tx00133a [doi]
AB  - The higher risk of adult neuropsychiatric diseases in individuals with low fetal 
      birth weight may be related to brain-derived neurotrophic factor (BDNF) signaling 
      pathway inhibition. Here, we investigated whether prenatal food restriction (PFR) 
      induces neurobehavioral alterations in adult female offspring and explored the 
      underlying intrauterine programming mechanism. Pregnant Wistar rats in the PFR 
      group were fed 50% of the daily food intake of control rats from gestational day 
      (GD) 11 to 20; some pregnant rats were sacrificed at GD20, and the remaining 
      female pups had normal delivery and were fed a post-weaning high-fat diet (HFD) 
      and half of them were exposed to an unpredictable chronic stress (UCS) from 
      postnatal week (PW) 21. All adult female offspring were sacrificed at PW24. At 
      GD20, PFR altered fetal hippocampal structure and function, increased 
      glucocorticoid receptor (GR) expression, and decreased mineralocorticoid receptor 
      (MR), BDNF and synaptic plasticity-related gene expressions. At PW24, PFR induced 
      depression-like behavioral abnormalities in adult rat offspring fed an HFD. These 
      rats exhibited depression- and anxiety-like behavioral changes after HFD/UCS. 
      Furthermore, the hippocampal morphology of the PFR group showed abnormal changes 
      in adult offspring fed an HFD and more serious damage after HFD/UCS. These 
      changes were accompanied by increased serum corticosterone levels, elevated GR 
      expression, and reduced expression of the BDNF signaling pathway and synaptic 
      plasticity-related genes in the hippocampus. In conclusion, PFR may induce 
      neurobehavioral abnormalities in adult offspring, especially those exposed to 
      UCS, through high levels of glucocorticoids, which increase hippocampal GR 
      expression and decrease BDNF expression.
FAU - He, Bo
AU  - He B
AUID- ORCID: 0000-0002-4029-5435
AD  - Department of Pharmacology , Wuhan University School of Basic Medical Sciences , 
      Wuhan 430071 , China . Email: wanghui19@whu.edu.cn ; Email: 
      xuyidan70188@whu.edu.cn ; ; Tel: +86 27 68758665.
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Disease , Wuhan 
      430071 , China.
FAU - Xu, Dan
AU  - Xu D
AUID- ORCID: 0000-0003-4408-2469
AD  - Department of Pharmacology , Wuhan University School of Basic Medical Sciences , 
      Wuhan 430071 , China . Email: wanghui19@whu.edu.cn ; Email: 
      xuyidan70188@whu.edu.cn ; ; Tel: +86 27 68758665.
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Disease , Wuhan 
      430071 , China.
FAU - Zhang, Chong
AU  - Zhang C
AD  - Department of Pharmacology , Wuhan University School of Basic Medical Sciences , 
      Wuhan 430071 , China . Email: wanghui19@whu.edu.cn ; Email: 
      xuyidan70188@whu.edu.cn ; ; Tel: +86 27 68758665.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Pharmacology , Wuhan University School of Basic Medical Sciences , 
      Wuhan 430071 , China . Email: wanghui19@whu.edu.cn ; Email: 
      xuyidan70188@whu.edu.cn ; ; Tel: +86 27 68758665.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Pharmacology , Wuhan University School of Basic Medical Sciences , 
      Wuhan 430071 , China . Email: wanghui19@whu.edu.cn ; Email: 
      xuyidan70188@whu.edu.cn ; ; Tel: +86 27 68758665.
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Disease , Wuhan 
      430071 , China.
LA  - eng
PT  - Journal Article
DEP - 20180122
PL  - England
TA  - Toxicol Res (Camb)
JT  - Toxicology research
JID - 101587950
PMC - PMC6060730
EDAT- 2018/08/10 06:00
MHDA- 2018/08/10 06:01
PMCR- 2019/01/22
CRDT- 2018/08/10 06:00
PHST- 2017/05/14 00:00 [received]
PHST- 2018/01/21 00:00 [accepted]
PHST- 2018/08/10 06:00 [entrez]
PHST- 2018/08/10 06:00 [pubmed]
PHST- 2018/08/10 06:01 [medline]
PHST- 2019/01/22 00:00 [pmc-release]
AID - c7tx00133a [pii]
AID - 10.1039/c7tx00133a [doi]
PST - epublish
SO  - Toxicol Res (Camb). 2018 Jan 22;7(2):293-306. doi: 10.1039/c7tx00133a. 
      eCollection 2018 Mar 1.