PMID- 30091667
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230523
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 125
IP  - 4
DP  - 2018 Oct 1
TI  - Skeletal muscle fiber characteristics in patients with chronic heart failure: 
      impact of disease severity and relation with muscle oxygenation during exercise.
PG  - 1266-1276
LID - 10.1152/japplphysiol.00057.2018 [doi]
AB  - Skeletal muscle function in patients with heart failure and reduced ejection 
      fraction (HFrEF) greatly determines exercise capacity. However, reports on 
      skeletal muscle fiber dimensions, fiber capillarization, and their physiological 
      importance are inconsistent. Twenty-five moderately impaired patients with HFrEF 
      and 25 healthy control (HC) subjects underwent muscle biopsy sampling. Type I and 
      type II muscle fiber characteristics were determined by immunohistochemistry. In 
      patients with HFrEF, enzymatic oxidative capacity was assessed, and pulmonary 
      oxygen uptake (V̇o(2)) and skeletal muscle oxygenation during maximal and 
      moderate-intensity exercise were measured using near-infrared spectroscopy. While 
      muscle fiber cross-sectional area (CSA) was not different between patients with 
      HFrEF and HC, the percentage of type I fibers was higher in HC (46 +/- 15 vs. 
      37 +/- 12%, respectively, P = 0.041). Fiber type distribution and CSA were not 
      different between patients in New York Heart Association (NYHA) class II and III. 
      Type I muscle fiber capillarization was higher in HFrEF compared with 
      HC[capillary-to-fiber perimeter exchange (CFPE) index: 5.70 +/- 0.92 vs. 
      5.05 +/- 0.82, respectively, P = 0.027]. Patients in NYHA class III had slower 
      V̇o(2) and muscle deoxygenation kinetics during onset of exercise and lower 
      muscle oxidative capacity than those in class II (P < 0.05). Also, fiber 
      capillarization was lower but not compared with HC. Higher CFPE index was related 
      to faster deoxygenation (r(spearman) = -0.682, P = 0.001), however, not to muscle 
      oxidative capacity (r = -0.282, P = 0.216). Type I muscle fiber capillarization 
      is higher in HFrEF compared with HC but not in patients with greater exercise 
      impairment. Greater capillarization may positively affect V̇o(2) kinetics by 
      enhancing muscle oxygen diffusion.NEW & NOTEWORTHY The skeletal myopathy of 
      chronic heart failure (HF) includes a greater percentage of fatigable type II 
      fibers and, for less impaired patients, greater skeletal muscle fiber 
      capillarization. Near-infrared spectroscopy measurements of skeletal muscle 
      oxygenation indicate that greater capillarization may compensate for reduced 
      blood flow in mild HF by enhancing the diffusive capacity of skeletal muscle. 
      This thereby augments and speeds oxygen extraction during contractions, which is 
      translated into faster pulmonary oxygen uptake kinetics.
FAU - Niemeijer, Victor M
AU  - Niemeijer VM
AD  - Department of Cardiology, Maxima Medical Centre, Veldhoven, The Netherlands.
AD  - Department of Applied Physics, Eindhoven University of Technology, Eindhoven, The 
      Netherlands.
FAU - Snijders, Tim
AU  - Snijders T
AD  - Department of Human Biology, Faculty of Health, Medicine and Life Sciences, 
      Maastricht University, Maastricht, The Netherlands.
FAU - Verdijk, Lex B
AU  - Verdijk LB
AD  - Department of Human Biology, Faculty of Health, Medicine and Life Sciences, 
      Maastricht University, Maastricht, The Netherlands.
FAU - van Kranenburg, Janneau
AU  - van Kranenburg J
AD  - Department of Human Biology, Faculty of Health, Medicine and Life Sciences, 
      Maastricht University, Maastricht, The Netherlands.
FAU - Groen, Bart B L
AU  - Groen BBL
AD  - Department of Human Biology, Faculty of Health, Medicine and Life Sciences, 
      Maastricht University, Maastricht, The Netherlands.
FAU - Holwerda, Andrew M
AU  - Holwerda AM
AD  - Department of Human Biology, Faculty of Health, Medicine and Life Sciences, 
      Maastricht University, Maastricht, The Netherlands.
FAU - Spee, Ruud F
AU  - Spee RF
AD  - Department of Cardiology, Maxima Medical Centre, Veldhoven, The Netherlands.
FAU - Wijn, Pieter F F
AU  - Wijn PFF
AD  - Department of Applied Physics, Eindhoven University of Technology, Eindhoven, The 
      Netherlands.
FAU - van Loon, Luc J C
AU  - van Loon LJC
AD  - Department of Human Biology, Faculty of Health, Medicine and Life Sciences, 
      Maastricht University, Maastricht, The Netherlands.
FAU - Kemps, Hareld M C
AU  - Kemps HMC
AD  - Department of Cardiology, Maxima Medical Centre, Veldhoven, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20180809
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
SB  - IM
OTO - NOTNLM
OT  - exercise capacity
OT  - fiber type
OT  - microvascular
OT  - myopathy
OT  - oxidative capacity
OT  - oxygen diffusion
EDAT- 2018/08/10 06:00
MHDA- 2018/08/10 06:01
CRDT- 2018/08/10 06:00
PHST- 2018/08/10 06:01 [medline]
PHST- 2018/08/10 06:00 [pubmed]
PHST- 2018/08/10 06:00 [entrez]
AID - 10.1152/japplphysiol.00057.2018 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2018 Oct 1;125(4):1266-1276. doi: 
      10.1152/japplphysiol.00057.2018. Epub 2018 Aug 9.