PMID- 30091732
OWN - NLM
STAT- MEDLINE
DCOM- 20181121
LR  - 20181121
IS  - 0794-859X (Print)
IS  - 0794-859X (Linking)
VI  - 33
IP  - 1
DP  - 2018 Jun 30
TI  - Serum Levels of Inflammatory Cytokines in Helminth Infested Pregnant Women and 
      Cord Blood of their Babies in Relation to Pregnancy Outcome.
PG  - 51-56
AB  - Pregnancy places a very high demand on physical, physiological and immunological 
      responses of females,especially when aggravated by parasitic infestation. There 
      is strong evidence that maternal infestations with helminth haveprofound effects 
      on immunity to helminths and other pathogens. This case-control study involved 
      245 pregnant women aged18-40 years (>30 weeks of gestation) recruited from three 
      secondary level hospitals in Ibadan, Nigeria. Morning stoolsamples collected from 
      pregnant women were examine for intestinal helminths using formol-ether 
      concentration method. Atotal of 38 participants comprising 17 Helminth Positive 
      (HP) and 21 Helminth Negative (HN) pregnant women werepurposely selected for the 
      study. Sera from these women (38) and their babies' cord (38) were analysed for 
      immune factors[interleukins 6 and 8 (IL-6, IL-8), tumor necrosis factor-alpha 
      (TNF-alpha) and immunoglobulin E (IgE)] were analyzed usingELISA. Anthropometric 
      indices [weight and height in mothers and babies and Chest Circumference (CC) in 
      babies] weremeasured using standard methods. Data were subjected to descriptive 
      statistics and analysed using Student t-test and Pearsoncorrelation at alpha0.05. 
      Only Ascaris lumbricoides was found in the 17 (6.9%) infested pregnant women. The 
      mean levels of IL-6 (57.8 +/- 32.8 vs 52.8+/-39.6 pg/mL), IL-8 (24.3+/-3.5 vs 22.0+/-7.1 
      pg/mL) and IgE (333.3+/-96.6 vs 242.3+/-96.8 IU/mL) weresimilar in HP when compared 
      with HN. In cord sera, IL-8 level was significantly higher in babies of HP 
      (23.7+/-3.9 pg/mL)compared with babies of HN (20.1+/-5.9 pg/mL). The levels of IL-6, 
      TNF-alpha and nutritional indices in HP had significantpositive correlation with 
      corresponding levels in babies of HP mothers. Only CC was significantly lowered 
      in babies of HPcompared with HN mothers. Other anthropometric indices were not 
      significantly different. Therefore, this present studysuggests that helminth 
      infestation may lead to strong Th2 immune responses as is reflected by the 
      cytokine levels of mothersand babies as well as anthropometric measurements of 
      babies of infested mothers. The outcomes of this study provide basisto deworm 
      pregnant women during pregnancy.
FAU - Olateru-Olagbegi, O A
AU  - Olateru-Olagbegi OA
AD  - Immunology Unit, Department of Chemical Pathology, College of Medicine, 
      University of Ibadan and School of Medical Laboratory Science, University College 
      Hospital, Ibadan. kemiabraham@gmail.com.
FAU - Omoruyi, E C
AU  - Omoruyi EC
FAU - Dada, R A
AU  - Dada RA
FAU - Edem, V F
AU  - Edem VF
FAU - Arinola, O G
AU  - Arinola OG
LA  - eng
PT  - Journal Article
DEP - 20180630
PL  - Nigeria
TA  - Niger J Physiol Sci
JT  - Nigerian journal of physiological sciences : official publication of the 
      Physiological Society of Nigeria
JID - 8811109
RN  - 0 (Cytokines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Anthropometry
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - Female
MH  - Fetal Blood/*metabolism
MH  - Helminthiasis/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Nigeria
MH  - Pregnancy
MH  - Pregnancy Complications, Parasitic/*blood
MH  - Pregnancy Outcome
MH  - Young Adult
EDAT- 2018/08/10 06:00
MHDA- 2018/11/22 06:00
CRDT- 2018/08/10 06:00
PHST- 2018/08/09 00:00 [received]
PHST- 2018/08/09 00:00 [accepted]
PHST- 2018/08/10 06:00 [entrez]
PHST- 2018/08/10 06:00 [pubmed]
PHST- 2018/11/22 06:00 [medline]
PST - epublish
SO  - Niger J Physiol Sci. 2018 Jun 30;33(1):51-56.