PMID- 30092983 OWN - NLM STAT- MEDLINE DCOM- 20181018 LR - 20181018 IS - 1879-1344 (Electronic) IS - 0144-8617 (Linking) VI - 198 DP - 2018 Oct 15 TI - Cellulose acetate electrospun nanofibers for drug delivery systems: Applications and recent advances. PG - 131-141 LID - S0144-8617(18)30726-4 [pii] LID - 10.1016/j.carbpol.2018.06.072 [doi] AB - Electrospinning process of nanofibers specially derivatives of cellulose presents high behest for developing several kinds of novel drug delivery systems (DDSs) due to their specific characteristics, the simplicity, beneficial and impressive top-down fabricating procedure. Moreover, the novel techniques of therapeutic agents for entrapment into core-shell nanofibers including single, coaxial and triaxial applied for DDSs. Recently, biodegradable polymers including derivatives of cellulose, hybrid materials, artificial and natural polymers have been remarkably considered. The acetate ester of cellulose (cellulose acetate (CA)), has been widely used due to biodegradability, chemical persistence, biocompatibility, and thermal constancy for DDSs. This article submits an overview of CA electrospinning techniques, applications, and its usage as a carrier for therapeutic agents in DDSs. Furthermore, in this study, we aimed to summarize the classification of therapeutic agents comprising antimicrobial agents incorporated CA fibers, antibacterial nanoparticles incorporated CA fibers, antioxidant agents loaded CA nanofibers, systematic and anti-inflammatory agents containing CA nanofibers. Our study has been concluded that CA electrospun nanofibers could be potentially applied as biocompatible and biodegradable for DDSs specifically in purpose-designed transdermal or wound dressing patches. CI - Copyright (c) 2018 Elsevier Ltd. All rights reserved. FAU - Khoshnevisan, Kamyar AU - Khoshnevisan K AD - Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: k-khoshnevisan@razi.tums.ac.ir. FAU - Maleki, Hassan AU - Maleki H AD - Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Samadian, Hadi AU - Samadian H AD - Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Shahsavari, Shadab AU - Shahsavari S AD - Department of Chemical Engineering, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran. FAU - Sarrafzadeh, Mohammad Hossein AU - Sarrafzadeh MH AD - School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran. FAU - Larijani, Bagher AU - Larijani B AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: larijanib@tums.ac.ir. FAU - Dorkoosh, Farid Abedin AU - Dorkoosh FA AD - Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. FAU - Haghpanah, Vahid AU - Haghpanah V AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. FAU - Khorramizadeh, Mohammad Reza AU - Khorramizadeh MR AD - Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: khoramza@tums.ac.ir. LA - eng PT - Journal Article PT - Review DEP - 20180618 PL - England TA - Carbohydr Polym JT - Carbohydrate polymers JID - 8307156 RN - 0 (Anti-Infective Agents) RN - 0 (Anti-Inflammatory Agents) RN - 0 (Antioxidants) RN - 3J2P07GVB6 (acetylcellulose) RN - 9004-34-6 (Cellulose) SB - IM MH - Animals MH - Anti-Infective Agents/administration & dosage MH - Anti-Inflammatory Agents/administration & dosage MH - Antioxidants/administration & dosage MH - Cellulose/administration & dosage/*analogs & derivatives MH - *Drug Delivery Systems MH - Humans MH - Nanofibers/*administration & dosage OTO - NOTNLM OT - Alkannin (PubChem CID: 72521) OT - Amoxicillin (PubChem CID: 33613) OT - Anti-inflammatory agents OT - Antimicrobial agents OT - Antioxidant agents OT - Asiaticoside (PubChem CID: 108062) OT - Cellulose acetate OT - Cellulose acetate (PubChem CID: 348285308) OT - Chlorhexidine (PubChem CID: 9552079) OT - Cisplatin (PubChem CID: 341139396) OT - Curcumin (PubChem CID: 969516) OT - Drug delivery systems OT - Electrospun nanofibers OT - Ferulic acid (PubChem CID: 445858) OT - Ketoprofen (PubChem CID: 134994171) OT - Naproxen (PubChem CID: 319172369) OT - Nisin (PubChem CID: 16133235) OT - Rosemary (PubChem CID: 5281792) OT - Shikonin (PubChem CID: 5208) OT - Silymarin (PubChem CID: 319084266) OT - Tetracycline hydrochloride (PubChem CID: 54704426) OT - Vitamin A acid (PubChem CID: 223992671) OT - Vitamin E (PubChem CID: 85165371) OT - [6]-gingerol (PubChem CID: 14330776) OT - bis (N-choloro-2, 2, 6, 6-tetramethyl-4-piperidinyl) sebacate (CI-BTMP) (PubChem CID: 13035) EDAT- 2018/08/11 06:00 MHDA- 2018/10/20 06:00 CRDT- 2018/08/11 06:00 PHST- 2018/01/23 00:00 [received] PHST- 2018/04/16 00:00 [revised] PHST- 2018/06/14 00:00 [accepted] PHST- 2018/08/11 06:00 [entrez] PHST- 2018/08/11 06:00 [pubmed] PHST- 2018/10/20 06:00 [medline] AID - S0144-8617(18)30726-4 [pii] AID - 10.1016/j.carbpol.2018.06.072 [doi] PST - ppublish SO - Carbohydr Polym. 2018 Oct 15;198:131-141. doi: 10.1016/j.carbpol.2018.06.072. Epub 2018 Jun 18.