PMID- 30093342 OWN - NLM STAT- MEDLINE DCOM- 20190903 LR - 20220129 IS - 2451-9030 (Electronic) IS - 2451-9022 (Linking) VI - 3 IP - 10 DP - 2018 Oct TI - Resting-State Connectivity and Its Association With Cognitive Performance, Educational Attainment, and Household Income in the UK Biobank. PG - 878-886 LID - S2451-9022(18)30158-7 [pii] LID - 10.1016/j.bpsc.2018.06.007 [doi] AB - BACKGROUND: Cognitive ability is an important predictor of lifelong physical and mental well-being, and impairments are associated with many psychiatric disorders. Higher cognitive ability is also associated with greater educational attainment and increased household income. Understanding neural mechanisms underlying cognitive ability is of crucial importance for determining the nature of these associations. In the current study, we examined the spontaneous activity of the brain at rest to investigate its relationships with not only cognitive ability but also educational attainment and household income. METHODS: We used a large sample of resting-state neuroimaging data from the UK Biobank (n = 3950). RESULTS: First, analysis at the whole-brain level showed that connections involving the default mode network (DMN), frontoparietal network (FPN), and cingulo-opercular network (CON) were significantly positively associated with levels of cognitive performance assessed by a verbal-numerical reasoning test (standardized beta cingulo-opercular values ranged from 0.054 to 0.097, p(corrected) < .038). Connections associated with higher levels of cognitive performance were also significantly positively associated with educational attainment (r = .48, n = 4160) and household income (r = .38, n = 3793). Furthermore, analysis on the coupling of functional networks showed that better cognitive performance was associated with more positive DMN-CON connections, decreased cross-hemisphere connections between the homotopic network in the CON and FPN, and stronger CON-FPN connections (absolute betas ranged from 0.034 to 0.063, p(corrected) < .045). CONCLUSIONS: The current study found that variation in brain resting-state functional connectivity was associated with individual differences in cognitive ability, largely involving the DMN and lateral prefrontal network. In addition, we provide evidence of shared neural associations of cognitive ability, educational attainment, and household income. CI - Copyright (c) 2018 Society of Biological Psychiatry. All rights reserved. FAU - Shen, Xueyi AU - Shen X AD - Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom. Electronic address: s1517658@sms.ed.ac.uk. FAU - Cox, Simon R AU - Cox SR AD - Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom. FAU - Adams, Mark J AU - Adams MJ AD - Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom. FAU - Howard, David M AU - Howard DM AD - Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom. FAU - Lawrie, Stephen M AU - Lawrie SM AD - Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom. FAU - Ritchie, Stuart J AU - Ritchie SJ AD - Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom. FAU - Bastin, Mark E AU - Bastin ME AD - Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom. FAU - Deary, Ian J AU - Deary IJ AD - Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom. FAU - McIntosh, Andrew M AU - McIntosh AM AD - Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom. FAU - Whalley, Heather C AU - Whalley HC AD - Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom. LA - eng GR - MC_PC_17228/MRC_/Medical Research Council/United Kingdom GR - MR/R024065/1/MRC_/Medical Research Council/United Kingdom GR - MR/M013111/1/MRC_/Medical Research Council/United Kingdom GR - 104036/Z/14/Z/WT_/Wellcome Trust/United Kingdom GR - Wellcome Trust/United Kingdom GR - MC_QA137853/MRC_/Medical Research Council/United Kingdom GR - MR/K026992/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180704 PL - United States TA - Biol Psychiatry Cogn Neurosci Neuroimaging JT - Biological psychiatry. Cognitive neuroscience and neuroimaging JID - 101671285 SB - IM CIN - Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Oct;3(10):824-825. PMID: 30297031 MH - Adult MH - Aged MH - *Biological Specimen Banks MH - Brain/physiology/*physiopathology MH - Brain Mapping/methods MH - Cognition/*physiology MH - Female MH - Humans MH - Male MH - Middle Aged MH - Neural Pathways/physiology/*physiopathology MH - Neuropsychological Tests MH - Rest/physiology MH - United Kingdom PMC - PMC6289224 OTO - NOTNLM OT - Big data OT - Cognition OT - Educational attainment OT - Household income OT - Resting-state fMRI OT - UK Biobank EDAT- 2018/08/11 06:00 MHDA- 2019/09/04 06:00 PMCR- 2018/10/01 CRDT- 2018/08/11 06:00 PHST- 2018/03/22 00:00 [received] PHST- 2018/06/18 00:00 [revised] PHST- 2018/06/18 00:00 [accepted] PHST- 2018/08/11 06:00 [pubmed] PHST- 2019/09/04 06:00 [medline] PHST- 2018/08/11 06:00 [entrez] PHST- 2018/10/01 00:00 [pmc-release] AID - S2451-9022(18)30158-7 [pii] AID - 10.1016/j.bpsc.2018.06.007 [doi] PST - ppublish SO - Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Oct;3(10):878-886. doi: 10.1016/j.bpsc.2018.06.007. Epub 2018 Jul 4.