PMID- 30093543
OWN - NLM
STAT- MEDLINE
DCOM- 20190405
LR  - 20190405
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 105
IP  - 2
DP  - 2019 Jan
TI  - Long-term outcomes of His bundle pacing in patients with heart failure with left 
      bundle branch block.
PG  - 137-143
LID - 10.1136/heartjnl-2018-313415 [doi]
AB  - OBJECTIVES: His bundle pacing (HBP) can potentially correct left bundle branch 
      block (LBBB). We aimed to assess the efficacy of HBP to correct LBBB and 
      long-term clinical outcomes with HBP in patients with heart failure (HF). 
      METHODS: This is an observational study of patients with HF with typical LBBB who 
      were indicated for pacing therapy and were consecutively enrolled from one 
      centre. Permanent HBP leads were implanted if the LBBB correction threshold was 
      <3.5V/0.5 ms or 3.0 V/1.0 ms. Pacing parameters, left ventricular ejection 
      fraction (LVEF), left ventricular end-systolic volume (LVESV) and New York Heart 
      Association (NYHA) Class were assessed during follow-up. RESULTS: In 74 enrolled 
      patients (69.6+/-9.2 years and 43 men), LBBB correction was acutely achieved in 72 
      (97.3%) patients, and 56 (75.7%) patients received permanent HBP (pHBP) while 18 
      patients did not receive permanent HBP (non-permanent HBP), due to no LBBB 
      correction (n=2), high LBBB correction thresholds (n=10) and fixation failure 
      (n=6). The median follow-up period of pHBP was 37.1 (range 15.0-48.7) months. 
      Thirty patients with pHBP had completed 3-year follow-up, with LVEF increased 
      from baseline 32.4+/-8.9% to 55.9+/-10.7% (p<0.001), LVESV decreased from a baseline 
      of 137.9+/-64.1 mL to 52.4+/-32.6 mL (p<0.001) and NYHA Class improvement from 
      baseline 2.73+/-0.58 to 1.03+/-0.18 (p<0.001). LBBB correction threshold remained 
      stable with acute threshold of 2.13+/-1.19 V/0.5 ms to 2.29+/-0.92 V/0.5 ms at 3-year 
      follow-up (p>0.05). CONCLUSIONS: pHBP improved LVEF, LVESV and NYHA Class in 
      patients with HF with typical LBBB.
CI  - (c) Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Huang, Weijian
AU  - Huang W
AD  - Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
AD  - The Key Lab of Cardiovascular Disease of Wenzhou, Wenzhou, China.
FAU - Su, Lan
AU  - Su L
AD  - Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
AD  - The Key Lab of Cardiovascular Disease of Wenzhou, Wenzhou, China.
FAU - Wu, Shengjie
AU  - Wu S
AD  - Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
AD  - The Key Lab of Cardiovascular Disease of Wenzhou, Wenzhou, China.
FAU - Xu, Lei
AU  - Xu L
AD  - Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
AD  - The Key Lab of Cardiovascular Disease of Wenzhou, Wenzhou, China.
FAU - Xiao, Fangyi
AU  - Xiao F
AD  - Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
AD  - The Key Lab of Cardiovascular Disease of Wenzhou, Wenzhou, China.
FAU - Zhou, Xiaohong
AU  - Zhou X
AD  - CRHF Division, Medtronic plc, Mounds View, Minnesota, USA.
FAU - Mao, Guangyun
AU  - Mao G
AD  - Department of Preventive Medicine, School of Public Health, Wenzhou Medical 
      University, Wenzhou, China.
FAU - Vijayaraman, Pugazhendhi
AU  - Vijayaraman P
AD  - Cardiac Electrophysiology, Geisinger Heart Institute, Wilkes Barre, Pennsylvania, 
      USA.
FAU - Ellenbogen, Kenneth A
AU  - Ellenbogen KA
AD  - Department of Cardiology, Virginia Commonwealth University Health System, 
      Richmond, Virginia, USA.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180809
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
MH  - Aged
MH  - Bundle of His/*physiopathology
MH  - Bundle-Branch Block/complications/physiopathology/*therapy
MH  - Cardiac Catheterization
MH  - Cardiac Pacing, Artificial/*methods
MH  - Echocardiography
MH  - *Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/complications/physiopathology/*therapy
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Stroke Volume/*physiology
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - cardiac arrhythmias and resuscitation science
OT  - heart failure
OT  - pacemakers
COIS- Competing interests: XZ is an employee of Medtronic plc. PV and KAE are 
      consultants, investigators and receive honoraria from Medtronic plc.
EDAT- 2018/08/11 06:00
MHDA- 2019/04/06 06:00
CRDT- 2018/08/11 06:00
PHST- 2018/04/08 00:00 [received]
PHST- 2018/06/19 00:00 [revised]
PHST- 2018/07/09 00:00 [accepted]
PHST- 2018/08/11 06:00 [pubmed]
PHST- 2019/04/06 06:00 [medline]
PHST- 2018/08/11 06:00 [entrez]
AID - heartjnl-2018-313415 [pii]
AID - 10.1136/heartjnl-2018-313415 [doi]
PST - ppublish
SO  - Heart. 2019 Jan;105(2):137-143. doi: 10.1136/heartjnl-2018-313415. Epub 2018 Aug 
      9.