PMID- 30094036
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 2053-3624 (Print)
IS  - 2053-3624 (Electronic)
IS  - 2053-3624 (Linking)
VI  - 5
IP  - 2
DP  - 2018
TI  - Transcatheter aortic valve implantation in decompensated aortic stenosis within 
      the same hospital admission: early clinical experience.
PG  - e000827
LID - 10.1136/openhrt-2018-000827 [doi]
LID - e000827
AB  - OBJECTIVE: Severe decompensated aortic valve stenosis is associated with 
      noticeable reduction in survival. Until recently the options for such patients 
      were either high-risk surgery or percutaneous balloon valvuloplasty and medical 
      therapy which does not add any survival benefits and associated with high rate of 
      complications. We present our experience in the use of transcatheter aortic valve 
      implantation (TAVI) in patients with decompensated severe aortic stenosis 
      requiring urgent intervention in the same hospital admission. METHODS: In this 
      observational study, all patients who were admitted with decompensated severe 
      aortic stenosis were enrolled. Elective patients were excluded from the study. 
      Perioperative records were analysed and clinical, echocardiographic and survival 
      data were presented. RESULTS: 76 patients with a mean age of 81+/-6 years were 
      enrolled. All patients presented with New York Heart Association (NYHA) IV 
      status. Femoral approach was performed in 86.8%. Median postoperative hospital 
      stay was 6 days and intensive care unit admission rate was 15%. At follow-up, 
      61.8% of patients were in NYHA status I/II. Moderate or more paravalvular leak 
      occurred in 5.2% of patients. Permanent pacemaker was required in 14.4% of 
      patients. The incidence of in-hospital death was 2.6%. Kaplan-Meier analysis 
      indicated a survival rate of 81% at 1 year. CONCLUSIONS: Urgent in-hospital TAVI 
      is feasible as the first-line treatment in decompensated severe aortic stenosis. 
      In our cohort, it showed to be safe and achieved satisfactory survival rates and 
      symptom control.
FAU - Abdelaziz, Mahmoud
AU  - Abdelaziz M
AD  - Heart and Lung Centre, New Cross Hospital, Wolverhampton, UK.
FAU - Khogali, Saib
AU  - Khogali S
AD  - Heart and Lung Centre, New Cross Hospital, Wolverhampton, UK.
FAU - Cotton, James M
AU  - Cotton JM
AD  - Heart and Lung Centre, New Cross Hospital, Wolverhampton, UK.
FAU - Meralgia, Antonella
AU  - Meralgia A
AD  - Heart and Lung Centre, New Cross Hospital, Wolverhampton, UK.
FAU - Matuszewski, Maciej
AU  - Matuszewski M
AD  - Heart and Lung Centre, New Cross Hospital, Wolverhampton, UK.
FAU - Luckraz, Heyman
AU  - Luckraz H
AD  - Heart and Lung Centre, New Cross Hospital, Wolverhampton, UK.
LA  - eng
PT  - Journal Article
DEP - 20180725
PL  - England
TA  - Open Heart
JT  - Open heart
JID - 101631219
PMC - PMC6074622
OTO - NOTNLM
OT  - aortic valve disease
OT  - minimally invasive
OT  - surgery-valve
COIS- Competing interests: None declared.
EDAT- 2018/08/11 06:00
MHDA- 2018/08/11 06:01
PMCR- 2018/07/25
CRDT- 2018/08/11 06:00
PHST- 2018/03/29 00:00 [received]
PHST- 2018/05/17 00:00 [revised]
PHST- 2018/06/13 00:00 [accepted]
PHST- 2018/08/11 06:00 [entrez]
PHST- 2018/08/11 06:00 [pubmed]
PHST- 2018/08/11 06:01 [medline]
PHST- 2018/07/25 00:00 [pmc-release]
AID - openhrt-2018-000827 [pii]
AID - 10.1136/openhrt-2018-000827 [doi]
PST - epublish
SO  - Open Heart. 2018 Jul 25;5(2):e000827. doi: 10.1136/openhrt-2018-000827. 
      eCollection 2018.