PMID- 30094892
OWN - NLM
STAT- MEDLINE
DCOM- 20190910
LR  - 20190910
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Linking)
VI  - 57
IP  - 38
DP  - 2018 Sep 17
TI  - Self-Propelled Nanomotors for Thermomechanically Percolating Cell Membranes.
PG  - 12463-12467
LID - 10.1002/anie.201806759 [doi]
AB  - We report a near-infrared (NIR) light-powered Janus mesoporous silica nanomotor 
      (JMSNM) with macrophage cell membrane (MPCM) cloaking that can actively seek 
      cancer cells and thermomechanically percolate cell membrane. Upon exposure to NIR 
      light, a heat gradient across the Janus boundary of the JMSNMs is generated by 
      the photothermal effect of the Au half-shells, resulting in a self-thermophoretic 
      force that propels the JMSNMs. In biological medium, the MPCM camouflaging can 
      not only prevent dissociative biological blocks from adhering to JMSNMs but also 
      improve the seeking sensitivity of the nanomotors by specifically recognizing 
      cancer cells. The biofriendly propulsion and recognition capability enable JMSNMs 
      to achieve the active seeking and bind to the membrane of cancer cells. 
      Subsequent illumination with NIR then triggers the photothermal effect of 
      MPCM@JMSNMs to thermomechanically perforate the cytomembranes for guest molecular 
      injection. This approach integrates the functions of active seeking, 
      cytomembranes perforating, and thermomechanical therapy in nanomotors, which may 
      pave the way to apply self-propelled motors in biomedical fields.
CI  - (c) 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Xuan, Mingjun
AU  - Xuan M
AD  - Key Lab of Microsystems and Microstructures Manufacturing, Micro/Nanotechnology 
      Research Centre, Academy of Fundamental and Interdisciplinary Sciences, Harbin 
      Institute of Technology, Yikuangjie 2, Harbin, 150080, China.
FAU - Shao, Jingxin
AU  - Shao J
AD  - Key Lab of Microsystems and Microstructures Manufacturing, Micro/Nanotechnology 
      Research Centre, Academy of Fundamental and Interdisciplinary Sciences, Harbin 
      Institute of Technology, Yikuangjie 2, Harbin, 150080, China.
FAU - Gao, Changyong
AU  - Gao C
AD  - Key Lab of Microsystems and Microstructures Manufacturing, Micro/Nanotechnology 
      Research Centre, Academy of Fundamental and Interdisciplinary Sciences, Harbin 
      Institute of Technology, Yikuangjie 2, Harbin, 150080, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Key Lab of Microsystems and Microstructures Manufacturing, Micro/Nanotechnology 
      Research Centre, Academy of Fundamental and Interdisciplinary Sciences, Harbin 
      Institute of Technology, Yikuangjie 2, Harbin, 150080, China.
FAU - Dai, Luru
AU  - Dai L
AD  - CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National 
      Center for Nanoscience and Technology, Beiyitiao 11, Beijing, 100190, China.
FAU - He, Qiang
AU  - He Q
AUID- ORCID: 0000-0002-3557-6865
AD  - Key Lab of Microsystems and Microstructures Manufacturing, Micro/Nanotechnology 
      Research Centre, Academy of Fundamental and Interdisciplinary Sciences, Harbin 
      Institute of Technology, Yikuangjie 2, Harbin, 150080, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180828
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
RN  - 0 (Alexa Fluor 488 C5-maleimide)
RN  - 0 (Maleimides)
RN  - 7440-57-5 (Gold)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Biomechanical Phenomena
MH  - Cell Line, Tumor
MH  - Cell Membrane/*chemistry/metabolism
MH  - Gold/chemistry
MH  - Humans
MH  - *Infrared Rays
MH  - Maleimides/chemistry
MH  - Microscopy, Confocal
MH  - Nanostructures/*chemistry
MH  - Permeability
MH  - Porosity
MH  - Silicon Dioxide/chemistry
MH  - Temperature
MH  - Time-Lapse Imaging
OTO - NOTNLM
OT  - Janus nanomotor
OT  - actively seeking
OT  - cell membrane cloak
OT  - self-propulsion
OT  - thermomechanically perforating
EDAT- 2018/08/11 06:00
MHDA- 2019/09/11 06:00
CRDT- 2018/08/11 06:00
PHST- 2018/06/12 00:00 [received]
PHST- 2018/07/12 00:00 [revised]
PHST- 2018/08/11 06:00 [pubmed]
PHST- 2019/09/11 06:00 [medline]
PHST- 2018/08/11 06:00 [entrez]
AID - 10.1002/anie.201806759 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12463-12467. doi: 
      10.1002/anie.201806759. Epub 2018 Aug 28.