PMID- 30095059
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20211204
IS  - 2212-3946 (Electronic)
IS  - 1574-888X (Linking)
VI  - 13
IP  - 8
DP  - 2018
TI  - Human Umbilical Cord Mesenchymal Stem Cells Therapy for Insulin Resistance: A 
      Novel Strategy in Clinical Implication.
PG  - 658-664
LID - 10.2174/1574888X13666180810154048 [doi]
AB  - There is increasing evidence reporting that as a common phenomenon in MetS 
      relative diseases, insulin resistance (IR) is regarded as an independent 
      etiological factor and a warning indicator of MetS occurrence. Therefore, for the 
      special group (overweight or obesity), clinical regular monitoring of IR is an 
      important basis for the prevention and early intervention of MetS relative 
      diseases. This surveys reveals that human umbilical cord mesenchymal stem cells 
      (HUC-MSCs)possess a kind of potential: it may become a possible theraphy for IR 
      in type 2 diabetes mellitus (T2DM) and related diseases. Specific emphasis is 
      focused on evaluating the improvement IR function of HUC-MSCs under the 
      background of development in vitro and in vivo. Next, the action mechanisms of 
      HUC-MSCs is discussed, and some of their advantages and disadvantages in the 
      course of clinic application are presented. The final section highlights the 
      application of HUC-MSCs in T2DM and relative diseases at this stage. Up to now, 
      although many questions remain unresolved, we still consider that HUC-MSCs is one 
      of the best therapy ameliorating IR in the future.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Bi, Sheng
AU  - Bi S
AD  - The affiliated first Hospital Jiamusi University, Jiamusi, China.
FAU - Nie, Qing
AU  - Nie Q
AD  - Weifang Center for Disease Control and Prevention, Shandong Province, China.
FAU - Wang, Wei-Qun
AU  - Wang WQ
AD  - College of Basic Medicine, Jiamusi University, Jiamusi, China.
FAU - Zhu, Yan-Li
AU  - Zhu YL
AD  - The affiliated first Hospital Jiamusi University, Jiamusi, China.
FAU - Ma, Xue-Mei
AU  - Ma XM
AD  - The affiliated first Hospital Jiamusi University, Jiamusi, China.
FAU - Wang, Chun-Min
AU  - Wang CM
AD  - College of Basic Medicine, Jiamusi University, Jiamusi, China.
FAU - Zhang, Bao-Cheng
AU  - Zhang BC
AD  - College of Basic Medicine, Jiamusi University, Jiamusi, China.
FAU - Li, Han-Yang
AU  - Li HY
AD  - College of Basic Medicine, 2015 Grade, Clinic Medicine, Jiamusi University, 
      Jiamusi, China.
FAU - Zhang, Qiang
AU  - Zhang Q
AD  - College of Public Health, Jiamusi University, Jiamusi, China.
FAU - Chen, Guang
AU  - Chen G
AD  - College of Basic Medicine, Jiamusi University, Jiamusi, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Stem Cell Res Ther
JT  - Current stem cell research & therapy
JID - 101272517
SB  - IM
MH  - Diabetes Mellitus/therapy
MH  - Humans
MH  - *Insulin Resistance
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology
MH  - Translational Research, Biomedical
MH  - Umbilical Cord/*cytology
OTO - NOTNLM
OT  - Human umlilical cord mesenchymal stem cells
OT  - T2DM
OT  - clinical implication
OT  - insulin resistance
OT  - obesity
OT  - overweight.
EDAT- 2018/08/11 06:00
MHDA- 2018/12/18 06:00
CRDT- 2018/08/11 06:00
PHST- 2018/02/11 00:00 [received]
PHST- 2018/05/05 00:00 [revised]
PHST- 2018/08/01 00:00 [accepted]
PHST- 2018/08/11 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2018/08/11 06:00 [entrez]
AID - CSCR-EPUB-92335 [pii]
AID - 10.2174/1574888X13666180810154048 [doi]
PST - ppublish
SO  - Curr Stem Cell Res Ther. 2018;13(8):658-664. doi: 
      10.2174/1574888X13666180810154048.