PMID- 30095393
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20190215
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 39
IP  - 4
DP  - 2018 Jul 1
TI  - Allergic sensitization and clinical outcomes in urban children with asthma, 
      2013-2016.
PG  - 281-288
LID - 10.2500/aap.2018.39.4147 [doi]
AB  - BACKGROUND: The aim of this study was to examine if food and/or aeroallergen 
      sensitization was associated with worse asthma, pulmonary function tests (PFT), 
      and laboratory markers. METHODS: At our institution, 386 children with asthma 
      were divided into allergic and nonallergic groups based on allergen-specific 
      immunoglobulin E (IgE) testing classes 1-6 versus 0. Asthma severity and/or 
      control, IgE level, eosinophil counts and/or percentages, forced vital capacity 
      (FVC), forced expiratory volume in the first second of expiration (FEV1), and 
      FEV1/FVC, were compared by using bivariate, regression, and subgroup analyses for 
      children who were highly allergic (>/=4 allergens). RESULTS: A total of 291 
      subjects with asthma were allergic, significantly older, and had higher mean IgE 
      levels and eosinophil counts and percentages (all p < 0.001). A total of 203 
      subjects who were highly allergic had worse obstruction on PFTs. Increasing age 
      predicted allergen sensitization after confounder adjustment, odds ratio (OR) 
      1.54 (95% confidence interval [CI], 1.18-2.02). Similarly, PFT obstruction was 
      associated with multiple allergen sensitization (OR 0.97 [95% CI, 0.93-1.02]). 
      CONCLUSION: Increasing age predicted allergic sensitization and multiple allergen 
      sensitization. Worse obstruction on PFT also predicted multiple allergen 
      sensitization. Continued surveillance of aeroallergen sensitization and PFT 
      results may be beneficial in asthma management, particularly in older urban 
      children.
FAU - Nagarajan, Sairaman
AU  - Nagarajan S
AD  - From the Department of Pediatrics, State University of New York Downstate Medical 
      Center, Brooklyn, New York.
FAU - Ahmad, Sabina
AU  - Ahmad S
AD  - From the Department of Pediatrics, State University of New York Downstate Medical 
      Center, Brooklyn, New York.
FAU - Quinn, Markus
AU  - Quinn M
AD  - From the Department of Pediatrics, State University of New York Downstate Medical 
      Center, Brooklyn, New York.
FAU - Agrawal, Sabhyata
AU  - Agrawal S
AD  - From the Department of Pediatrics, State University of New York Downstate Medical 
      Center, Brooklyn, New York.
FAU - Manilich, Elena
AU  - Manilich E
AD  - Department of Biostatistics, John Carroll University, Cleveland, Ohio.
FAU - Concepcion, Emily
AU  - Concepcion E
AD  - From the Department of Pediatrics, State University of New York Downstate Medical 
      Center, Brooklyn, New York.
FAU - Lee, Haesoon
AU  - Lee H
AD  - From the Department of Pediatrics, State University of New York Downstate Medical 
      Center, Brooklyn, New York.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Asthma/diagnosis/*epidemiology/history/*immunology
MH  - Biomarkers
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - History, 21st Century
MH  - Humans
MH  - *Immunization
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Patient Outcome Assessment
MH  - Respiratory Function Tests
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - *Urban Population
MH  - Young Adult
PMC - PMC6052173
COIS- The authors have no conflicts of interest to declare pertaining to this article
EDAT- 2018/08/11 06:00
MHDA- 2019/02/12 06:00
PMCR- 2018/07/01
CRDT- 2018/08/11 06:00
PHST- 2018/08/11 06:00 [entrez]
PHST- 2018/08/11 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - AAP186-17 [pii]
AID - 10.2500/aap.2018.39.4147 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2018 Jul 1;39(4):281-288. doi: 10.2500/aap.2018.39.4147.