PMID- 30095400
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20190215
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 39
IP  - 4
DP  - 2018 Jul 1
TI  - Differences in cytokine levels between the nasal polyps of adolescents with local 
      allergic and adolescents with allergic or nonallergic rhinitis.
PG  - e30-e37
LID - 10.2500/aap.2018.39.4135 [doi]
AB  - BACKGROUND: Local allergic rhinitis (LAR) is rhinitis with a localized nasal 
      allergic response in the absence of systemic allergy. This study aimed to 
      evaluate the pathogenesis specific to LAR compared with allergic rhinitis (AR) 
      and nonallergic rhinitis (NAR) by using cytokines from polypous tissues. METHODS: 
      We recruited 43 patients with AR (n = 15; mean age, 17.4 years), LAR (n = 12; 
      mean age, 15.9 years), and NAR (n = 16; mean age, 15.6 years) who underwent 
      polypectomy. Atopic status was defined as presenting a sufficiently high total 
      immunoglobulin E (IgE) serum concentration and skin-prick test or serum allergen 
      test. Immunoassays were performed by using polyp tissue homogenates to quantify 
      the levels of regulated on activation of normal T cell expressed and secreted 
      (RANTES), tumor necrosis factor (TNF) alpha, interleukin (IL) 5, and sera to 
      assess total IgE and eosinophil cationic protein. RESULTS: RANTES levels were 
      higher in patients with LAR than in patients with AR and NAR. There was a 
      significant correlation in the concentration of RANTES between polyp tissue 
      homogenates and serum (R2 = 0.51, p < 0.05). The levels of IL-5, TNF alpha, and 
      interferon gamma also demonstrated positive correlations between polyp tissue 
      homogenates and serum; however, they were not significantly different. 
      CONCLUSION: Results of our study indicated that RANTES may play an important role 
      and contribute to allergic reaction in LAR, and RANTES may be related to the 
      pathogenesis of LAR.
FAU - Choi, Young-Jin
AU  - Choi YJ
AD  - From the Department of Pediatrics, College of Medicine, Hanyang University Seoul, 
      Korea.
FAU - Kang, Ha-Na
AU  - Kang HN
AD  - From the Department of Pediatrics, College of Medicine, Hanyang University Seoul, 
      Korea.
FAU - Kim, Joo-Hwa
AU  - Kim JH
AD  - From the Department of Pediatrics, College of Medicine, Hanyang University Seoul, 
      Korea.
FAU - Oh, Jae-Won
AU  - Oh JW
AD  - From the Department of Pediatrics, College of Medicine, Hanyang University Seoul, 
      Korea.
FAU - Jeong, Jin Hyeok
AU  - Jeong JH
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang 
      University Seoul, Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Child
MH  - Cytokines/blood/*metabolism
MH  - Eosinophils/immunology/metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Nasal Polyps/immunology/*metabolism
MH  - Nasal Provocation Tests
MH  - Rhinitis/immunology/*metabolism
MH  - Rhinitis, Allergic/immunology/*metabolism
MH  - Young Adult
EDAT- 2018/08/11 06:00
MHDA- 2019/02/12 06:00
CRDT- 2018/08/11 06:00
PHST- 2018/08/11 06:00 [entrez]
PHST- 2018/08/11 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
AID - 10.2500/aap.2018.39.4135 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2018 Jul 1;39(4):e30-e37. doi: 10.2500/aap.2018.39.4135.