PMID- 30098201
OWN - NLM
STAT- MEDLINE
DCOM- 20190405
LR  - 20190405
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 59
IP  - 10
DP  - 2018 Aug 1
TI  - Retinal Microvascular Impairment in the Early Stages of Parkinson's Disease.
PG  - 4115-4122
LID - 10.1167/iovs.17-23230 [doi]
AB  - PURPOSE: To detect the retinal microvascular impairment using optical coherence 
      tomography angiography (OCT-A) in patients with Parkinson's disease (PD) and find 
      a correlation between the microvascular impairment and the neuronal damage. 
      METHODS: This is a prospective, observational study including 49 eyes from 38 PD 
      patients in their early stages and 34 eyes from 28 healthy controls with 
      comparable age range. Macula microvasculature was evaluated with the 
      spectral-domain optical coherence tomography (SD-OCT) angiography and 
      intraretinal layer thickness evaluated with the SD-OCT. A custom algorithm was 
      used for custom segmentation of retinal thickness and quantification of the 
      superficial and deep microvascular density of the macula, respectively. RESULTS: 
      PD patients showed reduced microvascular density in most of the areas of the 
      whole retina. In the superficial retinal capillary plexus, statistical difference 
      (P < 0.01) was seen in the total annular zone (TAZ), superior, temporal, 
      inferior, and nasal zones. In PD patients, there was a strong correlation between 
      the average ganglion cell layer and inner plexiform (GCIP) thickness and the TAZ 
      of the superficial microvascular density (r = 0.062, P = 0.032). CONCLUSION: We 
      demonstrated that retinal microvascular density decreased in PD patients. The 
      correlation between microvascular impairment in the superficial retinal capillary 
      layer and GCIP thinning also revealed that the retinal microvascular abnormality 
      may contribute to the neurodegeneration in PD patients. OCT-A with quantitative 
      analysis offers a new path of study and will likely be useful in the future as an 
      objective biomarker for detecting vessel impairment in early stages of PD.
FAU - Kwapong, William Robert
AU  - Kwapong WR
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Ye, Hua
AU  - Ye H
AD  - The Neurology Department, Wenzhou Peoples' Hospital, Wenzhou, Zhejiang, China.
FAU - Peng, Chenlei
AU  - Peng C
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Zhuang, Xiran
AU  - Zhuang X
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Wang, Jianhua
AU  - Wang J
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, 
      Miami, Florida, United States.
FAU - Shen, Meixiao
AU  - Shen M
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Lu, Fan
AU  - Lu F
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Macula Lutea/*blood supply
MH  - Male
MH  - Microvessels/*pathology
MH  - Middle Aged
MH  - Parkinson Disease/*pathology
MH  - Prospective Studies
MH  - Retinal Vessels/*pathology
MH  - Tomography, Optical Coherence
EDAT- 2018/08/12 06:00
MHDA- 2019/04/06 06:00
CRDT- 2018/08/12 06:00
PHST- 2018/08/12 06:00 [entrez]
PHST- 2018/08/12 06:00 [pubmed]
PHST- 2019/04/06 06:00 [medline]
AID - 2697355 [pii]
AID - 10.1167/iovs.17-23230 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4115-4122. doi: 
      10.1167/iovs.17-23230.