PMID- 30098714
OWN - NLM
STAT- MEDLINE
DCOM- 20190308
LR  - 20230804
IS  - 1558-4410 (Electronic)
IS  - 0889-8529 (Print)
IS  - 0889-8529 (Linking)
VI  - 47
IP  - 3
DP  - 2018 Sep
TI  - Molecular Genetic Studies of Pancreatic Neuroendocrine Tumors: New Therapeutic 
      Approaches.
PG  - 525-548
LID - S0889-8529(18)30519-X [pii]
LID - 10.1016/j.ecl.2018.04.007 [doi]
AB  - Pancreatic neuroendocrine tumors (PNETs) arise sporadically or as part of 
      familial syndromes. Genetic studies of hereditary syndromes and whole exome 
      sequencing analysis of sporadic NETs have revealed the roles of some genes 
      involved in PNET tumorigenesis. The multiple endocrine neoplasia type 1 (MEN1) 
      gene is most commonly mutated. Its encoded protein, menin, has roles in 
      transcriptional regulation, genome stability, DNA repair, protein degradation, 
      cell motility and adhesion, microRNA biogenesis, cell division, cell cycle 
      control, and epigenetic regulation. Therapies targeting epigenetic regulation and 
      MEN1 gene replacement have been reported to be effective in preclinical models.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Stevenson, Mark
AU  - Stevenson M
AD  - Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and 
      Metabolism (OCDEM), University of Oxford, Churchill Hospital, Headington, Oxford 
      OX3 7LJ, UK.
FAU - Lines, Kate E
AU  - Lines KE
AD  - Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and 
      Metabolism (OCDEM), University of Oxford, Churchill Hospital, Headington, Oxford 
      OX3 7LJ, UK.
FAU - Thakker, Rajesh V
AU  - Thakker RV
AD  - Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and 
      Metabolism (OCDEM), University of Oxford, Churchill Hospital, Headington, Oxford 
      OX3 7LJ, UK. Electronic address: rajesh.thakker@ndm.ox.ac.uk.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - G1000467/MRC_/Medical Research Council/United Kingdom
GR  - G9825289/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Endocrinol Metab Clin North Am
JT  - Endocrinology and metabolism clinics of North America
JID - 8800104
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1
MH  - Neuroendocrine Tumors/*genetics/*therapy
MH  - Pancreatic Neoplasms/*genetics/*therapy
MH  - Proto-Oncogene Proteins/genetics
PMC - PMC7614857
MID - EMS181859
OTO - NOTNLM
OT  - Epigenetic
OT  - MEN1
OT  - Menin
OT  - PNETs
OT  - RAS
OT  - SSTRs
OT  - VHL
OT  - mTOR
COIS- Disclosure Statement: The authors have no conflicts of interest to disclose.
EDAT- 2018/08/14 06:00
MHDA- 2019/03/09 06:00
PMCR- 2023/08/01
CRDT- 2018/08/13 06:00
PHST- 2018/08/13 06:00 [entrez]
PHST- 2018/08/14 06:00 [pubmed]
PHST- 2019/03/09 06:00 [medline]
PHST- 2023/08/01 00:00 [pmc-release]
AID - S0889-8529(18)30519-X [pii]
AID - 10.1016/j.ecl.2018.04.007 [doi]
PST - ppublish
SO  - Endocrinol Metab Clin North Am. 2018 Sep;47(3):525-548. doi: 
      10.1016/j.ecl.2018.04.007.