PMID- 30099036
OWN - NLM
STAT- MEDLINE
DCOM- 20190906
LR  - 20190906
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 196
DP  - 2018 Dec
TI  - Combined Use of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer 
      Event-based Progression Analysis.
PG  - 65-71
LID - S0002-9394(18)30447-1 [pii]
LID - 10.1016/j.ajo.2018.08.007 [doi]
AB  - PURPOSE: To evaluate patterns of glaucomatous structural progression using the 
      combined retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer 
      (GCIPL) event-based progression analysis feature provided by spectral-domain 
      optical coherence tomography (SD-OCT)'s - (GPA) software. DESIGN: Retrospective 
      observational case series. METHODS: Seventy-nine (79) patients were identified 
      with open-angle glaucoma (OAG) showing clinically confirmed structural 
      progression within a minimum 3-year follow-up period. For each eye, RNFL and 
      GCIPL GPA data were obtained from serial SD-OCT data from 2012 to 2017. An 
      integrated GPA map thereafter was merged by vascular landmark-guided 
      superimposition of RNFL and GCIPL GPA event-based progression maps onto the RNFL 
      imagery (resulting in what we call the GPA PanoMap). The GPA PanoMap progression 
      patterns were classified as (1) RNFL-only, (2) GCIPL-only, (3) concurrent (both 
      RNFL and GCIPL), (4) GCIPL after RNFL, and (5) RNFL after GCIPL. The locations of 
      structural progression were classified, based on an earlier schematic model, as 
      (1) superior vulnerability zone (SVZ), (2) papillomacular bundle (PM), (3) 
      macular vulnerability zone (MVZ), and (4) inferoinferior portion. Structural 
      progression patterns on the GPA PanoMap were evaluated according to the location 
      of progression. Among the eyes with progression in the inferior hemiretina, 
      structural progression patterns on the GPA PanoMap were evaluated according to 
      the baseline structural damage. RESULTS: On the GPA PanoMap, when structural 
      progression was located in the SVZ or inferoinferior portion, it was detected 
      only in the RNFL area; when progression was located in the PM or MVZ, various 
      patterns were observed, among which the concurrent pattern was the majority in 
      both areas (43.8% and 45.6% in the PM and MVZ, respectively). Among the eyes with 
      progression in the inferior hemiretina (n = 66), the location of progression 
      varied but did not differ significantly according to the baseline deviation map 
      (P = .440). The progression patterns of MVZ were significantly different among 
      the baseline deviation map patterns (P = .023); however, all of the progression 
      patterns of the inferoinferior portion were RNFL-only. CONCLUSION: The various 
      progression patterns were confirmed according to the locations and baseline 
      patterns of glaucomatous structural change on the integrated GPA map (GPA 
      PanoMap). Combined use of RNFL and GCIPL GPA or the GPA PanoMap could be useful 
      for determination of structural progression and understanding of its patterns in 
      patients with glaucoma.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Lee, Won June
AU  - Lee WJ
AD  - Department of Ophthalmology, Hanyang University Seoul Hospital, Seoul, South 
      Korea; Department of Ophthalmology, Hanyang University College of Medicine, 
      Seoul, South Korea.
FAU - Na, Kyeong Ik
AU  - Na KI
AD  - Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University 
      College of Medicine, Seoul, South Korea.
FAU - Ha, Ahnul
AU  - Ha A
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, South Korea; Department of Ophthalmology, Seoul National University 
      Hospital, Seoul, South Korea.
FAU - Kim, Young Kook
AU  - Kim YK
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, South Korea; Department of Ophthalmology, Seoul National University 
      Hospital, Seoul, South Korea.
FAU - Jeoung, Jin Wook
AU  - Jeoung JW
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, South Korea; Department of Ophthalmology, Seoul National University 
      Hospital, Seoul, South Korea.
FAU - Park, Ki Ho
AU  - Park KH
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, South Korea; Department of Ophthalmology, Seoul National University 
      Hospital, Seoul, South Korea. Electronic address: kihopark@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180809
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease Progression
MH  - Female
MH  - Glaucoma, Open-Angle/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/methods
MH  - Young Adult
EDAT- 2018/08/14 06:00
MHDA- 2019/09/07 06:00
CRDT- 2018/08/13 06:00
PHST- 2018/03/13 00:00 [received]
PHST- 2018/08/03 00:00 [revised]
PHST- 2018/08/03 00:00 [accepted]
PHST- 2018/08/14 06:00 [pubmed]
PHST- 2019/09/07 06:00 [medline]
PHST- 2018/08/13 06:00 [entrez]
AID - S0002-9394(18)30447-1 [pii]
AID - 10.1016/j.ajo.2018.08.007 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2018 Dec;196:65-71. doi: 10.1016/j.ajo.2018.08.007. Epub 2018 
      Aug 9.