PMID- 30099412
OWN - NLM
STAT- MEDLINE
DCOM- 20190918
LR  - 20240109
IS  - 1553-3840 (Electronic)
IS  - 1553-3840 (Linking)
VI  - 16
IP  - 2
DP  - 2018 Aug 11
TI  - Asymmetric dimethylarginine and soluble inter-cellular adhesion molecule-1 serum 
      levels alteration following ginger supplementation in patients with type 2 
      diabetes: a randomized double-blind, placebo-controlled clinical trial.
LID - /j/jcim.2019.16.issue-2/jcim-2018-0019/jcim-2018-0019.xml [pii]
LID - 10.1515/jcim-2018-0019 [doi]
AB  - Aims Patients with type 2 diabetes mellitus (T2DM) are prone to cardiovascular 
      disease (CVD) due to inflammation process and oxidative stress. ADMA (Asymmetric 
      dimethylarginine) and ICAM-1 (inter-cellular adhesion molecule-1) play an 
      important role in CVD pathogenesis. Ginger as an anti-oxidant and 
      anti-inflammation can effect on these biomarkers. The aim of present study was to 
      characterize the effect of ginger supplementation on ADMA and ICAM-1 serum levels 
      in patients with T2DM. Methods The present study is a randomized double-blind 
      clinical trial which is conducted among 45 diabetic patients (nginger=23, 
      nplacebo=22). The participants were randomly divided into two intervention and 
      placebo groups which were received 2 g ginger powder and 2 g wheat flour for 
      10 weeks, respectively. ADMA and ICAM-1 concentration were measured by ELISA 
      method. Results Ginger supplementation decreased ADMA serum levels significantly 
      (P=0.002) and sICAM-1 serum levels marginally (P=0.097) in supplementation group 
      after intervention. No significant difference was observed between placebo and 
      supplementation groups. Conclusions Present study was conducted among patients 
      with type 2 diabetes mellitus to investigate the effect of ginger supplementation 
      on ADMA and sICAM-1 levels. There was a significant decrement in ADMA serum 
      concentration and slight reduction in sICAM-1 levels in intervention group. The 
      amount of reduction in both biomarkers was not statistically significant in 
      between-groups comparison.
FAU - Zarezadeh, Meysam
AU  - Zarezadeh M
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Saedisomeolia, Ahmad
AU  - Saedisomeolia A
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Khorshidi, Masoud
AU  - Khorshidi M
AD  - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Kord Varkane, Hamed
AU  - Kord Varkane H
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Makhdoomi Arzati, Motahareh
AU  - Makhdoomi Arzati M
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Abdollahi, Mina
AU  - Abdollahi M
AD  - AmirAlam Hospital Complex, Marvasti Hospital, Tehran University of Medical 
      Sciences, Tehran, Iran (Islamic Republic of).
FAU - Yekaninejad, Mir Saeed
AU  - Yekaninejad MS
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Hashemi, Rezvan
AU  - Hashemi R
AD  - Department of Geriatric Medicine, Ziaeian Hospital, School of Medicine, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Effatpanah, Mohammad
AU  - Effatpanah M
AD  - School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Mohammadzadeh Honarvar, Niyaz
AU  - Mohammadzadeh Honarvar N
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180811
PL  - Germany
TA  - J Complement Integr Med
JT  - Journal of complementary & integrative medicine
JID - 101313855
RN  - 0 (Biomarkers)
RN  - 0 (Plant Extracts)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Adult
MH  - Arginine/*analogs & derivatives/blood
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy
MH  - Dietary Supplements/*analysis
MH  - Double-Blind Method
MH  - Female
MH  - Zingiber officinale/*chemistry
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Male
MH  - Middle Aged
MH  - Plant Extracts/*administration & dosage
OTO - NOTNLM
OT  - asymmetric dimethylarginine
OT  - ginger
OT  - inter-cellular adhesion molecule-1
OT  - type 2 diabetes
OT  - vascular complications
EDAT- 2018/08/14 06:00
MHDA- 2019/09/19 06:00
CRDT- 2018/08/13 06:00
PHST- 2018/02/15 00:00 [received]
PHST- 2018/07/09 00:00 [accepted]
PHST- 2018/08/14 06:00 [pubmed]
PHST- 2019/09/19 06:00 [medline]
PHST- 2018/08/13 06:00 [entrez]
AID - /j/jcim.ahead-of-print/jcim-2018-0019/jcim-2018-0019.xml [pii]
AID - 10.1515/jcim-2018-0019 [doi]
PST - epublish
SO  - J Complement Integr Med. 2018 Aug 
      11;16(2):/j/jcim.2019.16.issue-2/jcim-2018-0019/jcim-2018-0019.xml. doi: 
      10.1515/jcim-2018-0019.