PMID- 30099416
OWN - NLM
STAT- MEDLINE
DCOM- 20181005
LR  - 20221207
IS  - 0043-5147 (Print)
IS  - 0043-5147 (Linking)
VI  - 71
IP  - 4
DP  - 2018
TI  - [The analysis of association between ENPP1 K121Q polymorphism and risk factors of 
      type 2 diabetes mellitus in ukrainian population].
PG  - 815-820
AB  - OBJECTIVE: Introduction: More than 100 genes have been described associations 
      between single nucleotide polymorphisms and type 2 diabetes mellitus (T2DM). 
      Among these candidate genes, Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 
      (ENPP1), is located on the long arm of chromosome 6 (6q23.2) and encodes for a 
      protein which is one of the factors determining the insulin sensitivity. An 
      allelic polymorphism in exon 4 of ENPP1 (rs1044498) has been designated K121Q and 
      widely investigated in T2DM in different populations. The aim: To analyze the 
      association between ENPP1 K121Q polymorphism with the risk factors of type 2 
      diabetes mellitus in the Ukrainian population. PATIENTS AND METHODS: Materials 
      and methods: Venous blood of 317 patients with type 2 diabetes mellitus and 302 
      controls was used for analysis. ENPP1 K121Q genotyping was performed using 
      PCR-RFLP method. RESULTS: Results: Our results revealed that ratio of K/K 
      homozygotes, K/Q heterozygotes and Q/Q homozygotes between case and control 
      groups was significantly different (59.3%, 34.1%, 6.6% vs 67.9%, 28.5%, 3.6%, P = 
      0.05). Method of binary logistic regression shown that a reliable relationship 
      was established in the general group for KQ/QQ vs K/K genetic model (P = 0.027). 
      It was shown that in carriers of the minor Q-allele, the risk of T2DM is 1.4x 
      higher than in homozygotes in the main K-allele (95% CI = 1.043-2.016). After 
      adjusting for age, sex, smoking habit, BMI, obesity and the presence of 
      hypertension, the reliability of these results persisted (P = 0.026). CONCLUSION: 
      Conclusions: ENPP1 K121Q polymorphism is associated with T2DM in Ukrainian 
      population. In carriers of the minor Q-allele the risk of T2DM is 1.4x higher 
      than in homozygotes in the main K-allele. The risk increases in patients with BMI 
      >/= 25 kg/m2.
FAU - Marchenko, Irina V
AU  - Marchenko IV
AD  - Sumy State University, Sumy, Ukraine.
FAU - Dubovyk, Yevhen I
AU  - Dubovyk YI
AD  - Sumy State University, Sumy, Ukraine.
FAU - Matlai, Olha I
AU  - Matlai OI
AD  - Sumy State University, Sumy, Ukraine.
FAU - Biesiedina, Antonina A
AU  - Biesiedina AA
AD  - Sumy State University, Sumy, Ukraine.
FAU - Kniazkova, Polina V
AU  - Kniazkova PV
AD  - Sumy State University, Sumy, Ukraine.
FAU - Harbuzova, Yelizaveta A
AU  - Harbuzova YA
AD  - Sumy State University, Sumy, Ukraine.
LA  - rus
PT  - Journal Article
PL  - Poland
TA  - Wiad Lek
JT  - Wiadomosci lekarskie (Warsaw, Poland : 1960)
JID - 9705467
RN  - EC 3.1.4.- (Phosphoric Diester Hydrolases)
RN  - EC 3.1.4.1 (ectonucleotide pyrophosphatase phosphodiesterase 1)
RN  - EC 3.6.1.- (Pyrophosphatases)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Diabetes Mellitus, Type 2/diagnosis/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/genetics
MH  - Phosphoric Diester Hydrolases/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - *Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide
MH  - Pyrophosphatases/*genetics
MH  - Ukraine
MH  - White People/*genetics
OTO - NOTNLM
OT  - type 2 diabetes mellitus
OT  - ENPP1
OT  - gene polymorphism
EDAT- 2018/08/14 06:00
MHDA- 2018/10/06 06:00
CRDT- 2018/08/13 06:00
PHST- 2018/08/13 06:00 [entrez]
PHST- 2018/08/14 06:00 [pubmed]
PHST- 2018/10/06 06:00 [medline]
PST - ppublish
SO  - Wiad Lek. 2018;71(4):815-820.