PMID- 30100604
OWN - NLM
STAT- MEDLINE
DCOM- 20181031
LR  - 20220321
IS  - 2173-9110 (Electronic)
IS  - 1135-5727 (Linking)
VI  - 92
DP  - 2018 Aug 16
TI  - [Analysis of proton pump inhibitors anti-ulcer drugs use in the Araba district 
      primary care area].
LID - e201808047 [pii]
AB  - OBJECTIVE: The proton pump inhibitors (PPI) anti-ulcer drugs are one of the most 
      prescribed pharmacological groups in primary care. The objective of the work was 
      to know the prescription of PPI in a Primary Care Area, the Araba district of the 
      Basque Health Service, to advise family doctors about its correct use, and 
      encourage the prescription of the most efficient PPIs. METHODS: Descriptive study 
      of 200 family doctors PPI prescription at the Araba district of the Basque Health 
      Service. Data were obtained from prescriptions billed by pharmacies between 2009 
      and 2014. We analyzed the expenses and DHD (DDD per 1000 inhabitants/day) of PPIs 
      dispensed and the omeprazole relative uptake compared to other PPIs. Statistical 
      analysis was performed with IBM SPSS v23(R) statistic software. RESULTS: IBP 
      prescription increased by 23.75% (from 78.14 DHD in 2009 to 96.70 DHD in 2014). 
      Their use was much higher than that of other European countries. In the same 
      period, omeprazole relative prescription compared to other PPIs decreased by 
      4.56% (omeprazole % Defined daily dose (DDD) went from 74.67% in 2009 to 70.11% 
      in 2014). The overall expenditure of these medicines decreased by 17.60%. 
      CONCLUSIONS: There is an overall increase in the prescription of PPIs, although 
      the expenses have decreased due to price drop. Likewise there is a decrease in 
      the relative consumption of omeprazole, although the indications approved had not 
      changed. PPIs prescription should be done with caution since their unjustified 
      high use in the prevention of gastropathy increases the risk of inappropriate 
      prescriptions. The most recommended PPI continues to be omeprazole.
FAU - Martinez Gorostiaga, Javier
AU  - Martinez Gorostiaga J
AD  - Organizacion Sanitaria Integrada de Alava. OSI Araba. Osakidetza. 
      Vitoria-Gasteiz. Espana.
FAU - Echevarria Orella, Enrique
AU  - Echevarria Orella E
AD  - Departamento de Fisiologia. Facultad de Farmacia. Universidad del Pais Vasco 
      (UPV/EHU). Vitoria-Gasteiz. Espana.
FAU - Calvo Hernaez, Begona
AU  - Calvo Hernaez B
AD  - Area de Farmacia y Tecnologia Farmaceutica. Facultad de Farmacia. Universidad del 
      Pais Vasco (UPV/EHU). Vitoria-Gasteiz. Espana.
LA  - spa
PT  - Journal Article
TT  - Analisis de la utilizacion de antiulcerosos inhibidores de la bomba de protones 
      en el area de atencion primaria de la comarca Araba.
DEP - 20180816
PL  - Spain
TA  - Rev Esp Salud Publica
JT  - Revista espanola de salud publica
JID - 9600212
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Drug Utilization/statistics & numerical data/*trends
MH  - Humans
MH  - Medical Overuse/statistics & numerical data/trends
MH  - Peptic Ulcer/*drug therapy
MH  - Practice Patterns, Physicians'/statistics & numerical data/*trends
MH  - Primary Health Care/statistics & numerical data/*trends
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Spain
OTO - NOTNLM
OT  - Esomeprazole
OT  - Inappropriate prescription
OT  - Lansoprazole
OT  - Medicines use
OT  - Omeprazole
OT  - Overprescription
OT  - Pantoprazole
OT  - Primary care
OT  - Proton pump inhibitors
OT  - Rabeprazole
OT  - Spain
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2018/08/14 06:00
MHDA- 2018/11/01 06:00
CRDT- 2018/08/14 06:00
PHST- 2017/11/09 00:00 [received]
PHST- 2018/07/12 00:00 [accepted]
PHST- 2018/08/14 06:00 [entrez]
PHST- 2018/08/14 06:00 [pubmed]
PHST- 2018/11/01 06:00 [medline]
AID - e201808047 [pii]
PST - epublish
SO  - Rev Esp Salud Publica. 2018 Aug 16;92:e201808047.