PMID- 30101560
OWN - NLM
STAT- MEDLINE
DCOM- 20190510
LR  - 20200225
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Print)
IS  - 1545-5009 (Linking)
VI  - 65
IP  - 12
DP  - 2018 Dec
TI  - Feasibility and accuracy of UF/NCI phantoms and Monte Carlo retrospective 
      dosimetry in children treated on National Wilms Tumor Study protocols.
PG  - e27395
LID - 10.1002/pbc.27395 [doi]
AB  - PURPOSE: This pilot study was done to determine the feasibility and accuracy of 
      University of Florida/National Cancer Institute (UF/NCI) phantoms and Monte Carlo 
      (MC) retrospective dosimetry and had two aims: (1) to determine the anatomic 
      accuracy of UF/NCI phantoms by comparing 3D organ doses in National Wilms Tumor 
      Study (NWTS) patient-matched UF/NCI phantoms to organ doses in corresponding 
      patient-matched CT scans and (2) to compare infield and out-of-field organ 
      dosimetry using two dosimetry methods-standard radiation therapy (RT) treatment 
      planning systems (TPS) and MC dosimetry in these two anatomic models. METHODS: 
      Twenty NWTS patient-matched Digital Imaging and Communications in Medicine 
      (DICOM) files of UF/NCI phantoms and CT scans were imported into the Pinnacle RT 
      TPS. The NWTS RT fields (whole abdomen, flank, whole lung, or a combination) and 
      RT doses (10-45 Gy) were reconstructed in both models. Both TPS and MC dose 
      calculations were performed. For aim 1, the mean doses to the heart, kidney, 
      thyroid gland, testes, and ovaries using TPS and MC in both models were 
      statistically compared. For aim 2, the TPS and MC dosimetry for these organs in 
      both models were statistically compared. RESULTS: For aim 1, there was no 
      significant difference between phantom and CT scan dosimetry for any of the 
      organs using either TPS or MC dosimetry. For aim 2, there was a significant 
      difference between TPS and MC dosimetry for both CT scan and phantoms for all 
      organs. Although the doses for infield organs were similar for both TPS and MC, 
      the doses for near-field and out-of-field organs were consistently higher for 90% 
      to 100% of MC doses; however, the absolute dose difference was small (<1 Gy). 
      CONCLUSIONS: This pilot study has demonstrated that the patient-matched UF/NCI 
      phantoms together with MC dosimetry is an accurate model for performing 
      retrospective 3D dosimetry in large-scale epidemiology studies such as the NWTS.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Kalapurakal, John A
AU  - Kalapurakal JA
AUID- ORCID: 0000-0001-7405-6769
AD  - Department of Radiation Oncology, Northwestern University, Chicago, Illinois.
FAU - Gopalakrishnan, Mahesh
AU  - Gopalakrishnan M
AD  - Department of Radiation Oncology, Northwestern University, Chicago, Illinois.
FAU - Mille, Matthew
AU  - Mille M
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National 
      Institute of Health, Bethesda, Maryland.
FAU - Helenowski, Irene
AU  - Helenowski I
AD  - Northwestern University, Chicago, Illinois.
FAU - Peterson, Susan
AU  - Peterson S
AD  - Fred Hutchinson Cancer Center, Seattle, Washington.
FAU - Rigsby, Cynthia
AU  - Rigsby C
AD  - Department of Medical Imaging, Ann and Robert Lurie Children's Hospital, Chicago, 
      Illinois.
FAU - Laurie, Fran
AU  - Laurie F
AD  - Quality Assurance Review Center, Lincoln, Rhode Island.
FAU - Jung, Jae Won
AU  - Jung JW
AD  - Department of Physics, East Carolina University, Greenville, North Carolina.
FAU - Fitzgerald, Thomas J
AU  - Fitzgerald TJ
AD  - Quality Assurance Review Center, Lincoln, Rhode Island.
FAU - Lee, Choonsik
AU  - Lee C
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National 
      Institute of Health, Bethesda, Maryland.
LA  - eng
GR  - R01 CA219013/CA/NCI NIH HHS/United States
GR  - Z99 CA999999/Intramural NIH HHS/United States
GR  - ZIA CP010131-21/Intramural NIH HHS/United States
GR  - R01CA159547/Foundation for the National Institutes of Health/International
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180812
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Kidney Neoplasms/*radiotherapy
MH  - Male
MH  - Monte Carlo Method
MH  - Organs at Risk/radiation effects
MH  - *Phantoms, Imaging
MH  - Pilot Projects
MH  - Radiometry/*methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/instrumentation/*methods
MH  - Tomography, X-Ray Computed
MH  - Wilms Tumor/*radiotherapy
PMC - PMC6561477
MID - NIHMS983047
OTO - NOTNLM
OT  - Monte Carlo dosimetry
OT  - dosimetry
OT  - epidemiology
OT  - phantom model
OT  - radiation
COIS- Conflict of Interest: No
EDAT- 2018/08/14 06:00
MHDA- 2019/05/11 06:00
PMCR- 2019/12/01
CRDT- 2018/08/14 06:00
PHST- 2018/03/25 00:00 [received]
PHST- 2018/06/11 00:00 [revised]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2018/08/14 06:00 [pubmed]
PHST- 2019/05/11 06:00 [medline]
PHST- 2018/08/14 06:00 [entrez]
PHST- 2019/12/01 00:00 [pmc-release]
AID - 10.1002/pbc.27395 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2018 Dec;65(12):e27395. doi: 10.1002/pbc.27395. Epub 2018 
      Aug 12.