PMID- 30102400
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20220330
IS  - 1460-2393 (Electronic)
IS  - 1460-2393 (Linking)
VI  - 111
IP  - 11
DP  - 2018 Nov 1
TI  - Chronic Q fever: patient and treatment-related factors influencing long-term 
      quality of life.
PG  - 791-797
LID - 10.1093/qjmed/hcy171 [doi]
AB  - BACKGROUND: Chronic Q fever is accompanied by high mortality and morbidity, and 
      requires prolonged antibiotic treatment. Little is known on long-term quality of 
      life (LQOL) in chronic Q fever patients treated with antibiotics. AIM: To 
      identify patient and treatment-related factors associated with impaired LQOL in 
      chronic Q fever patients treated with antibiotics, and to assess patients' 
      perception on treatment. DESIGN: Cross-sectional study. METHODS: LQOL was 
      assessed with a validated questionnaire from the Nijmegen Clinical Screening 
      Instrument. Patients' perception on treatment was measured with three newly 
      developed questions. RESULTS: We included 64 patients: LQOL was impaired in 55% 
      (n = 35) after a median follow-up of 5 years. Median treatment duration was 
      27 months. In multivariable analysis, treatment duration was significantly 
      associated with impaired LQOL (OR 1.07; 95%CI 1.02-1.12, P < 0.01 per month 
      increase). Age, gender, number of antibiotic regimens, surgical intervention, 
      complications, diagnostic classification, focus of infection or registration of 
      side effects during treatment were not associated with impaired LQOL. After start 
      of treatment, 17 patients (27%) perceived improvement of their condition. 
      Disadvantages of treatment were experienced on a daily basis by 24 patients (69%) 
      with impaired LQOL and 13 patients (46%) without impaired LQOL (P = 0.04). 
      CONCLUSIONS: LQOL in chronic Q fever patients treated with antibiotics is 
      impaired in more than half of patients 5 years after diagnosis. Antibiotic 
      treatment duration was the only variable associated with impaired LQOL. The 
      majority of patients experienced disadvantages on a daily basis, highlighting the 
      high burden of disease and treatment.
FAU - van Roeden, S E
AU  - van Roeden SE
AD  - Department of Internal Medicine and Infectious Diseases, University Medical 
      Center Utrecht, Heidelberglaan 100, CX Utrecht, The Netherlands.
FAU - Reukers, D F M
AU  - Reukers DFM
AD  - Department of Primary and Community Care, Academic Collaborative Center AMPHI, 
      Radboud University Medical Center, Geert Grooteplein Zuid 10, GA Nijmegen, The 
      Netherlands.
FAU - van Jaarsveld, C H M
AU  - van Jaarsveld CHM
AD  - Department of Primary and Community Care, Academic Collaborative Center AMPHI, 
      Radboud University Medical Center, Geert Grooteplein Zuid 10, GA Nijmegen, The 
      Netherlands.
FAU - Kampschreur, L M
AU  - Kampschreur LM
AD  - Department of Internal Medicine and Infectious Diseases, Medical Center 
      Leeuwarden, Henri Dunantweg 2, AD Leeuwarden, The Netherlands.
FAU - Hoepelman, I M
AU  - Hoepelman IM
AD  - Department of Internal Medicine and Infectious Diseases, University Medical 
      Center Utrecht, Heidelberglaan 100, CX Utrecht, The Netherlands.
FAU - Wever, P C
AU  - Wever PC
AD  - Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, 
      Henri Dunantstraat 1, GZ 's-Hertogenbosch, The Netherlands.
FAU - Bleeker-Rovers, C P
AU  - Bleeker-Rovers CP
AD  - Department of Internal Medicine and Infectious Diseases and Radboud Expert Center 
      for Q fever, Radboud University Medical Center, Geert Grooteplein Zuid 10, GA 
      Nijmegen, The Netherlands.
FAU - Oosterheert, J J
AU  - Oosterheert JJ
AD  - Department of Internal Medicine and Infectious Diseases, University Medical 
      Center Utrecht, Heidelberglaan 100, CX Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - QJM
JT  - QJM : monthly journal of the Association of Physicians
JID - 9438285
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Aged
MH  - Anti-Bacterial Agents/adverse effects/*therapeutic use
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Netherlands
MH  - Q Fever/*diagnosis/*drug therapy
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 2018/08/14 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/08/14 06:00
PHST- 2018/03/06 00:00 [received]
PHST- 2018/08/14 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/08/14 06:00 [entrez]
AID - 5068534 [pii]
AID - 10.1093/qjmed/hcy171 [doi]
PST - ppublish
SO  - QJM. 2018 Nov 1;111(11):791-797. doi: 10.1093/qjmed/hcy171.