PMID- 30102949
OWN - NLM
STAT- MEDLINE
DCOM- 20190917
LR  - 20190917
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 120
DP  - 2018 Nov
TI  - Pyrethroid bifenthrin induces oxidative stress, neuroinflammation, and neuronal 
      damage, associated with cognitive and memory impairment in murine hippocampus.
PG  - 121-133
LID - S0197-0186(18)30171-2 [pii]
LID - 10.1016/j.neuint.2018.08.004 [doi]
AB  - Exposure to synthetic pyrethroid (SPs) pesticides such as bifenthrin (BF) has 
      been associated with adverse neurodevelopmental outcomes and cognitive 
      impairments, but the underlying neurobiological mechanism is poorly understood so 
      far. The present study has been designed to evaluate changes in behavior and in 
      biomarkers of oxidative stress and neuroinflammation in the hippocampus of rats 
      subchronically treated with BF. Rats exposed daily to BF at doses of 0.6 and 
      2.1 mg/kg b. w. for 60 days exhibited spatial and cognitive impairments as well 
      as memory dysfunction after 60 days. This repeated BF treatment also 
      significantly increased mRNA expression of pro-inflammatory cytokines tumor 
      necrosis factor (TNF-alpha), interleukin (IL-1beta), (IL-6), nuclear factor erythroid-2 
      (Nrf2), cyclooxygenase-2 (COX-2), nuclear factor-kappaB pathway (NF-kappaB), and 
      prostaglandin E(2) (PGE(2)) in the hippocampus. It further resulted in a 
      significant increase in protein levels of Nrf2, COX-2, microsomal prostaglandin 
      synthase-1 (mPGES-1) and NF-kappaB. This was accompanied by oxidative/nitrosative 
      stress in the hippocampus of treated rats, as shown by increased levels of 
      malondialdehyde (MDA), protein carbonyls (PCO), and nitric oxide (NO), and 
      reduced levels of enzymatic (catalase, superoxide dismutase, and glutathione 
      peroxidase) and non-enzymatic (reduced glutathione) antioxidants. The data are in 
      line with those obtained in organotypic hippocampal slice cultures (OHSCs) 
      isolated from mouse brain and exposed to BF for 72 h, showing neuronal death only 
      at the high dose of 20 muM when compared to controls. These findings suggest that 
      exposure to BF induces neuronal damage, alters redox state, and causes 
      neuroinflammation in the hippocampus, which might lead to cognitive and memory 
      impairment.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Gargouri, Brahim
AU  - Gargouri B
AD  - Neurochemistry and Neuroimmunology Research Group, Department of Psychiatry and 
      Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, 
      University of Freiburg, Hauptstrasse 5, 79104, Freiburg, Germany; Laboratory of 
      Toxicology-Microbiology and Environmental Health (17ES06), Sciences Faculty of 
      Sfax, University of Sfax, BP1171, 3000, Sfax, Tunisia. Electronic address: 
      brahim.gargouri@uniklinik-freiburg.de.
FAU - Yousif, Nizar M
AU  - Yousif NM
AD  - Neurochemistry and Neuroimmunology Research Group, Department of Psychiatry and 
      Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, 
      University of Freiburg, Hauptstrasse 5, 79104, Freiburg, Germany; Faculty of 
      Biology, University of Freiburg, Freiburg, Germany. Electronic address: 
      nizar.yousif@uniklinik-freiburg.de.
FAU - Attaai, Abdelraheim
AU  - Attaai A
AD  - Institute for Anatomy and Cell Biology, Department of Molecular Embryology, 
      Albert-Ludwigs-University Freiburg, Albertstrasse 17, 79104, Freiburg Germany; 
      Department of Anatomy and Histology, Faculty of Veterinary Medicine, Assiut 
      University, Egypt. Electronic address: abdelraheim.attaai@vet.au.edu.eg.
FAU - Bouchard, Michele
AU  - Bouchard M
AD  - Department of Environmental and Occupational Health, Chair in Toxicological Risk 
      Assessment and Management, University of Montreal, Roger-Gaudry Building, U424, 
      P.O. Box 6128, Main Station, Montreal, Quebec, H3C 3J7, Canada. Electronic 
      address: michele.bouchard@umontreal.ca.
FAU - Chtourou, Yassine
AU  - Chtourou Y
AD  - Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Sciences 
      Faculty of Sfax, University of Sfax, BP1171, 3000, Sfax, Tunisia. Electronic 
      address: yacine_chtourou@yahoo.fr.
FAU - Fiebich, Bernd L
AU  - Fiebich BL
AD  - Neurochemistry and Neuroimmunology Research Group, Department of Psychiatry and 
      Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, 
      University of Freiburg, Hauptstrasse 5, 79104, Freiburg, Germany. Electronic 
      address: bernd.fiebich@uniklinik-freiburg.de.
FAU - Fetoui, Hamadi
AU  - Fetoui H
AD  - Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Sciences 
      Faculty of Sfax, University of Sfax, BP1171, 3000, Sfax, Tunisia. Electronic 
      address: fetoui_hamadi@yahoo.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180810
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Biomarkers)
RN  - 0 (Pyrethrins)
RN  - 6B66JED0KN (bifenthrin)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cognition/drug effects
MH  - Cognitive Dysfunction/drug therapy/metabolism
MH  - Hippocampus/*drug effects/metabolism
MH  - Inflammation/*drug therapy/metabolism
MH  - Memory Disorders/drug therapy/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Pyrethrins/*pharmacology
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Bifenthrin
OT  - Cognitive impairment
OT  - Cytokines
OT  - Hippocampus
OT  - Nrf2
OT  - Oxidative stress
EDAT- 2018/08/14 06:00
MHDA- 2019/09/19 06:00
CRDT- 2018/08/14 06:00
PHST- 2018/05/30 00:00 [received]
PHST- 2018/08/06 00:00 [revised]
PHST- 2018/08/08 00:00 [accepted]
PHST- 2018/08/14 06:00 [pubmed]
PHST- 2019/09/19 06:00 [medline]
PHST- 2018/08/14 06:00 [entrez]
AID - S0197-0186(18)30171-2 [pii]
AID - 10.1016/j.neuint.2018.08.004 [doi]
PST - ppublish
SO  - Neurochem Int. 2018 Nov;120:121-133. doi: 10.1016/j.neuint.2018.08.004. Epub 2018 
      Aug 10.