PMID- 30103233 OWN - NLM STAT- MEDLINE DCOM- 20191119 LR - 20220331 IS - 1438-9010 (Electronic) IS - 1438-9010 (Linking) VI - 191 IP - 2 DP - 2019 Feb TI - Higher Detection Rates of Biologically Aggressive Breast Cancers in Mammography Screening than in the Biennial Interval. PG - 130-136 LID - 10.1055/a-0657-3970 [doi] AB - PURPOSE: Assessment of age group-dependent detection rates of invasive breast cancers among participants in mammography screening including the interval, classified into immunohistochemical subtypes indicating the intrinsic tumor aggressiveness. MATERIALS UND METHODS: The target population comprises women aged 50 - 69 years. All invasive breast cancers diagnosed in one screening (sc) unit during the implementation phase 1/2006 - 12/2010 or identified by the cancer registry during the biennial interval (iv) were categorized based on hormonal-receptor status (HR) and Her2-expression (Her2) into the following subtypes: a) HR+ Her2-, b) HR+ Her2 +, c) HR- Her2 + or d) HR- Her2- (triple-negative); Her2 + and triple-negative types were defined as aggressive. The calculated detection rates (DR, per thousand) were based on 53 375 sc-examinations and for the interval on 52 887 sc-negative examinations. RESULTS: The DRs of all subtypes were higher in screening versus the interval: (a) 4.95 per thousand (n = 264) vs. 1.00 per thousand (n = 53); b) 0.92 per thousand (n = 49) vs. 0.25 per thousand (n = 13); c) 0.36 per thousand (n = 19) vs. 0.06 per thousand (n = 3); d) 0.39 per thousand (n = 21) vs. 0.19 per thousand (n = 10). 77.4 per thousand (89/115) of all aggressive breast cancers including the following 2-year interval were diagnosed by screening. The sum of the DR of aggressive cancers was 1.67 per thousand in screening and 0.49 per thousand in the interval; the corresponding DRs for women aged 60 - 69 years [sc: 2.24 per thousand (51/22 814), iv: 0.58 per thousand (13/22 536)] were higher than among women aged 50 - 59 years [sc: 1.24 per thousand (38/30 561), iv: 0.43 per thousand (13/30 351)]. CONCLUSION: Screening has the potential for earlier diagnosis of aggressive tumor types as its detection rate is about three-fold higher compared to the interval. Within the target group, participants aged 60 - 69 years are at risk based on absolute numbers. They show a nearly two-fold higher detection rate of Her2-positive or triple-negative tumors compared to the age group 50 - 59 years. KEY POINTS: . Her2-positive and triple-negative detection rates are higher in screening than in the interval.. . 77 % of aggressive subtypes are diagnosed by screening, 23 % during the 2-year interval.. . The detection rate is highest among women aged 60 - 69 years in screening.. CITATION FORMAT: . Prange A, Bokhof B, Polzer P et al. Higher Detection Rates of Biologically Aggressive Breast Cancers in Mammography Screening than in the Biennial Interval. Fortschr Rontgenstr 2019; 191: 130 - 136. CI - (c) Georg Thieme Verlag KG Stuttgart . New York. FAU - Prange, Anna AU - Prange A AD - Institute of Clinical Radiology and Reference Center for Mammography Muenster, University of Muenster and University Hospital Muenster, Germany. FAU - Bokhof, Beate AU - Bokhof B AD - Institute of Clinical Radiology and Reference Center for Mammography Muenster, University of Muenster and University Hospital Muenster, Germany. FAU - Polzer, Philipp AU - Polzer P AD - Institute of Clinical Radiology and Reference Center for Mammography Muenster, University of Muenster and University Hospital Muenster, Germany. FAU - Tio, Joke AU - Tio J AD - Department of Gynecology and Obstetrics, University of Muenster and University Hospital Muenster, Germany. FAU - Radke, Isabel AU - Radke I AD - Department of Gynecology and Obstetrics, University of Muenster and University Hospital Muenster, Germany. FAU - Heidinger, Oliver AU - Heidinger O AD - Cancer Registry of North Rhine-Westphalia, Bochum, Germany. FAU - Heindel, Walter AU - Heindel W AD - Institute of Clinical Radiology and Reference Center for Mammography Muenster, University of Muenster and University Hospital Muenster, Germany. FAU - Weigel, Stefanie AU - Weigel S AD - Institute of Clinical Radiology and Reference Center for Mammography Muenster, University of Muenster and University Hospital Muenster, Germany. LA - eng LA - ger PT - Journal Article TT - Hohere Detektionsraten biologisch aggressiver Mammakarzinome im Mammografie-Screening als im 2-jahrigen Intervall. DEP - 20180813 PL - Germany TA - Rofo JT - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin JID - 7507497 RN - EC 2.7.10.1 (ERBB2 protein, human) RN - EC 2.7.10.1 (Receptor, ErbB-2) SB - IM MH - Age Factors MH - Aged MH - Breast Neoplasms/*diagnostic imaging MH - Early Detection of Cancer/*methods MH - Female MH - Germany MH - Guideline Adherence MH - Humans MH - Mammography/*methods MH - Middle Aged MH - Prognosis MH - Receptor, ErbB-2/analysis MH - Triple Negative Breast Neoplasms/diagnostic imaging COIS- Disclosure The authors report no conflicts of interest in this work. EDAT- 2018/08/14 06:00 MHDA- 2019/11/20 06:00 CRDT- 2018/08/14 06:00 PHST- 2018/08/14 06:00 [pubmed] PHST- 2019/11/20 06:00 [medline] PHST- 2018/08/14 06:00 [entrez] AID - 10.1055/a-0657-3970 [doi] PST - ppublish SO - Rofo. 2019 Feb;191(2):130-136. doi: 10.1055/a-0657-3970. Epub 2018 Aug 13.