PMID- 30103955
OWN - NLM
STAT- MEDLINE
DCOM- 20190627
LR  - 20190627
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 391
DP  - 2018 Aug 15
TI  - Epilepsy treatment patterns among patients with tuberous sclerosis complex.
PG  - 104-108
LID - S0022-510X(18)30261-2 [pii]
LID - 10.1016/j.jns.2018.06.011 [doi]
AB  - INTRODUCTION: Tuberous sclerosis complex (TSC) is a rare congenital disorder 
      often associated with epilepsy. However, real-world treatment patterns for 
      epilepsy in patients with TSC are not yet well categorized. METHODS: This study 
      included patients with TSC and epilepsy from fifteen clinics in the United States 
      and one in Belgium who were enrolled in the TSC Natural History Database 
      (2006-2014). Patient demographics and epilepsy treatment patterns, including the 
      use of anti-epileptic drugs (AEDs), epilepsy surgeries, and dietary therapies 
      were assessed. RESULTS: Of the 1328 patients with TSC in the database, 1110 
      (83.6%) were diagnosed with epilepsy. The median age of epilepsy diagnosis was 
      0.7 years. Of those who received treatment for epilepsy (92.3%), 99.5% were 
      prescribed AEDs, 25.3% underwent surgery, 7.9% were prescribed special diets, and 
      1% were prescribed mammalian target of rapamycin (mTOR) inhibitors. Of the 
      patients receiving AEDs, over half (64.5%) used >/=3 different AEDs, and 22.5% 
      underwent surgical treatment following AED initiation. Of the patients who 
      underwent surgery, 35.1% had subsequent surgery. CONCLUSION: The use of multiple 
      AEDs and surgical interventions may indicate a need for new therapies to reduce 
      the treatment burden among patients with TSC and epilepsy.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Song, Jinlin
AU  - Song J
AD  - Analysis Group, Inc., 111 Huntington Ave, Floor 14, Boston, MA 02199, United 
      States.
FAU - Swallow, Elyse
AU  - Swallow E
AD  - Analysis Group, Inc., 111 Huntington Ave, Floor 14, Boston, MA 02199, United 
      States. Electronic address: elyse.swallow@analysisgroup.com.
FAU - Said, Qayyim
AU  - Said Q
AD  - Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover, NJ 07936, 
      United States.
FAU - Peeples, Miranda
AU  - Peeples M
AD  - Analysis Group, Inc., 111 Huntington Ave, Floor 14, Boston, MA 02199, United 
      States.
FAU - Meiselbach, Mark
AU  - Meiselbach M
AD  - Analysis Group, Inc., 111 Huntington Ave, Floor 14, Boston, MA 02199, United 
      States.
FAU - Signorovitch, James
AU  - Signorovitch J
AD  - Analysis Group, Inc., 111 Huntington Ave, Floor 14, Boston, MA 02199, United 
      States.
FAU - Kohrman, Michael
AU  - Kohrman M
AD  - Akron Children's Hospital, 1 Perkins Square, Akron, OH 44308, United States.
FAU - Korf, Bruce
AU  - Korf B
AD  - University of Alabama at Birmingham, 1720 2(nd) Ave S, Birmingham, AL 35294, 
      United States.
FAU - Krueger, Darcy
AU  - Krueger D
AD  - Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 
      45229, United States.
FAU - Wong, Michael
AU  - Wong M
AD  - Washington University in Saint Louis, 1 Brookings Dr, St. Louis, MO 63130, United 
      States.
FAU - Sparagana, Steven
AU  - Sparagana S
AD  - Texas Scottish Rite Hospital for Children, 2222 Wellborn St, Dallas, TX 75219, 
      United States.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180615
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adolescent
MH  - Anticonvulsants/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Diet Therapy/trends
MH  - Epilepsy/*complications/epidemiology/genetics/*therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Neurosurgical Procedures/trends
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Tuberous Sclerosis/*complications/epidemiology/genetics/*therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Anti-epileptic drugs
OT  - Epilepsy
OT  - Treatment patterns
OT  - Tuberous Sclerosis Natural History Database
OT  - Tuberous sclerosis complex
EDAT- 2018/08/15 06:00
MHDA- 2019/06/30 06:00
CRDT- 2018/08/15 06:00
PHST- 2018/03/15 00:00 [received]
PHST- 2018/06/01 00:00 [revised]
PHST- 2018/06/13 00:00 [accepted]
PHST- 2018/08/15 06:00 [entrez]
PHST- 2018/08/15 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
AID - S0022-510X(18)30261-2 [pii]
AID - 10.1016/j.jns.2018.06.011 [doi]
PST - ppublish
SO  - J Neurol Sci. 2018 Aug 15;391:104-108. doi: 10.1016/j.jns.2018.06.011. Epub 2018 
      Jun 15.