PMID- 30104307
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20191022
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 8
IP  - 8
DP  - 2018 Aug 13
TI  - Cost-effectiveness of habit-based advice for weight control versus usual care in 
      general practice in the Ten Top Tips (10TT) trial: economic evaluation based on a 
      randomised controlled trial.
PG  - e017511
LID - 10.1136/bmjopen-2017-017511 [doi]
LID - e017511
AB  - OBJECTIVE: Ten Top Tips (10TT) is a primary care-led behavioural intervention 
      which aims to help adults reduce and manage their weight by following 10 weight 
      loss tips. The intervention promotes habit formation to encourage long-term 
      behavioural changes. The aim of this study was to estimate the cost-effectiveness 
      of 10TT in general practice from the perspective of the UK National Health 
      Service. DESIGN: An economic evaluation was conducted alongside an individually 
      randomised controlled trial. SETTING: 14 general practitioner practices in 
      England. PARTICIPANTS: All patients were aged >/=18 years, with body mass index 
      >/=30 kg/m(2). A total of 537 patients were recruited; 270 received the usual care 
      offered by their practices and 267 received the 10TT intervention. OUTCOMES 
      MEASURES: Health service use and quality-adjusted life years (QALYs) were 
      measured over 2 years. Analysis was conducted in terms of incremental net 
      monetary benefits (NMBs), using non-parametric bootstrapping and multiple 
      imputation. RESULTS: Over a 2-year time horizon, the mean costs and QALYs per 
      patient in the 10TT group were  pound1889 (95% CI  pound1522 to  pound2566) and 1.51 (95% CI 
      1.44 to 1.58). The mean costs and QALYs for usual care were  pound1925 (95% CI  pound1599 
      to  pound2251) and 1.51 (95% CI 1.45 to 1.57), respectively. This generated a mean 
      cost difference of - pound36 (95% CI - pound512 to  pound441) and a mean QALY difference of 
      0.001 (95% CI -0.080 to 0.082). The incremental NMB for 10TT versus usual care 
      was  pound49 (95% CI - pound1709 to  pound1800) at a maximum willingness to pay for a QALY of 
       pound20 000. 10TT had a 52% probability of being cost-effective at this threshold. 
      CONCLUSIONS: Costs and QALYs for 10TT were not significantly different from usual 
      care and therefore 10TT is as cost-effective as usual care. There was no evidence 
      to recommend nor advice against offering 10TT to obese patients in general 
      practices based on cost-effectiveness considerations. TRIAL REGISTRATION NUMBER: 
      ISRCTN16347068; Post-results.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text of 
      the article) 2018. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Patel, Nishma
AU  - Patel N
AD  - Department of Applied Health Research, University College London, London, UK.
FAU - Beeken, Rebecca J
AU  - Beeken RJ
AD  - Department of Behavioural Science and Health, University College London, London, 
      UK.
AD  - Leeds Institute of Health Sciences, University of Leeds, Leeds, UK.
FAU - Leurent, Baptiste
AU  - Leurent B
AD  - Department of Medical Statistics, London School of Hygiene & Tropical Medicine, 
      London, UK.
FAU - Omar, Rumana Z
AU  - Omar RZ
AD  - Department of Statistical Science, University College London, London, UK.
FAU - Nazareth, Irwin
AU  - Nazareth I
AD  - Department of Primary Care and Population Health, University College London, 
      London, UK.
FAU - Morris, Stephen
AU  - Morris S
AD  - Department of Applied Health Research, University College London, London, UK.
LA  - eng
SI  - ISRCTN/ISRCTN16347068
GR  - G080202/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180813
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Female
MH  - *Habits
MH  - Health Care Costs/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/economics/prevention & control
MH  - Patient Acceptance of Health Care/statistics & numerical data
MH  - Primary Health Care/economics/*methods
MH  - Quality-Adjusted Life Years
MH  - *Weight Reduction Programs/economics/methods
PMC - PMC6091904
OTO - NOTNLM
OT  - cost-effectiveness
OT  - primary care
OT  - weight loss programme
COIS- Competing interests: None declared.
EDAT- 2018/08/15 06:00
MHDA- 2019/10/23 06:00
PMCR- 2018/08/13
CRDT- 2018/08/15 06:00
PHST- 2018/08/15 06:00 [entrez]
PHST- 2018/08/15 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2018/08/13 00:00 [pmc-release]
AID - bmjopen-2017-017511 [pii]
AID - 10.1136/bmjopen-2017-017511 [doi]
PST - epublish
SO  - BMJ Open. 2018 Aug 13;8(8):e017511. doi: 10.1136/bmjopen-2017-017511.