PMID- 30105301
OWN - NLM
STAT- MEDLINE
DCOM- 20190308
LR  - 20190420
IS  - 2373-2822 (Electronic)
IS  - 2373-2822 (Linking)
VI  - 5
IP  - 4
DP  - 2018 Jul-Aug
TI  - Sensory Adaptation to Chemical Cues by Vomeronasal Sensory Neurons.
LID - 10.1523/ENEURO.0223-18.2018 [doi]
LID - ENEURO.0223-18.2018
AB  - Sensory adaptation is a source of experience-dependent feedback that impacts 
      responses to environmental cues. In the mammalian main olfactory system (MOS), 
      adaptation influences sensory coding at its earliest processing stages. Sensory 
      adaptation in the accessory olfactory system (AOS) remains incompletely explored, 
      leaving many aspects of the phenomenon unclear. We investigated sensory 
      adaptation in vomeronasal sensory neurons (VSNs) using a combination of in situ 
      Ca(2+) imaging and electrophysiology. Parallel studies revealed prominent 
      short-term sensory adaptation in VSNs upon repeated stimulation with mouse urine 
      and monomolecular bile acid ligands at interstimulus intervals (ISIs) less than 
      30 s. In such conditions, Ca(2+) signals and spike rates were often reduced by 
      more than 50%, leading to dramatically reduced chemosensory sensitivity. 
      Short-term adaptation was reversible over the course of minutes. Population 
      Ca(2+) imaging experiments revealed the presence of a slower form of VSN 
      adaptation that accumulated over dozens of stimulus presentations delivered over 
      tens of minutes. Most VSNs showed strong adaptation, but in a substantial VSN 
      subpopulation adaptation was diminished or absent. Investigation of same- and 
      opposite-sex urine responses in male and female VSNs revealed that adaptation to 
      same-sex cues occurred at ISIs up to 180 s, conditions that did not induce 
      adaptation to opposite-sex cues. This result suggests that VSN sensory adaptation 
      can be modulated by sensory experience. These studies comprehensively establish 
      the presence of VSN sensory adaptation and provide a foundation for future 
      inquiries into the molecular and cellular mechanisms of this phenomenon and its 
      impact on mammalian behavior.
FAU - Wong, Wen Mai
AU  - Wong WM
AUID- ORCID: 0000-0001-6451-2812
AD  - Department of Neuroscience, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390.
FAU - Nagel, Maximilian
AU  - Nagel M
AD  - Department of Chemosensation, Institute for Biology II, Rheinisch-Westfalische 
      Technische Hochschule Aachen University, Aachen D-52074, Germany.
FAU - Hernandez-Clavijo, Andres
AU  - Hernandez-Clavijo A
AUID- ORCID: 0000-0002-4122-3521
AD  - Neurobiology Group, SISSA, Scuola Internazionale Superiore di Studi Avanzati, 
      Trieste 34136, Italy.
FAU - Pifferi, Simone
AU  - Pifferi S
AUID- ORCID: 0000-0002-3687-3984
AD  - Neurobiology Group, SISSA, Scuola Internazionale Superiore di Studi Avanzati, 
      Trieste 34136, Italy.
FAU - Menini, Anna
AU  - Menini A
AUID- ORCID: 0000-0001-9304-0412
AD  - Neurobiology Group, SISSA, Scuola Internazionale Superiore di Studi Avanzati, 
      Trieste 34136, Italy.
FAU - Spehr, Marc
AU  - Spehr M
AUID- ORCID: 0000-0001-6616-4196
AD  - Department of Chemosensation, Institute for Biology II, Rheinisch-Westfalische 
      Technische Hochschule Aachen University, Aachen D-52074, Germany.
FAU - Meeks, Julian P
AU  - Meeks JP
AUID- ORCID: 0000-0002-7537-4491
AD  - Department of Neuroscience, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390.
LA  - eng
GR  - R01 DC015784/DC/NIDCD NIH HHS/United States
GR  - R21 NS104826/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180813
PL  - United States
TA  - eNeuro
JT  - eNeuro
JID - 101647362
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adaptation, Physiological/*physiology
MH  - Animals
MH  - Calcium/metabolism
MH  - Electrophysiological Phenomena/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Microscopy, Confocal
MH  - Sensory Receptor Cells/*physiology
MH  - Smell/*physiology
MH  - Vomeronasal Organ/*physiology
PMC - PMC6088365
OTO - NOTNLM
OT  - adaptation
OT  - calcium imaging
OT  - chemical senses
OT  - electrophysiology
OT  - olfaction
OT  - vomeronasal system
EDAT- 2018/08/15 06:00
MHDA- 2019/03/09 06:00
PMCR- 2018/08/13
CRDT- 2018/08/15 06:00
PHST- 2018/05/31 00:00 [received]
PHST- 2018/07/13 00:00 [revised]
PHST- 2018/07/18 00:00 [accepted]
PHST- 2018/08/15 06:00 [entrez]
PHST- 2018/08/15 06:00 [pubmed]
PHST- 2019/03/09 06:00 [medline]
PHST- 2018/08/13 00:00 [pmc-release]
AID - eN-NWR-0223-18 [pii]
AID - 10.1523/ENEURO.0223-18.2018 [doi]
PST - epublish
SO  - eNeuro. 2018 Aug 13;5(4):ENEURO.0223-18.2018. doi: 10.1523/ENEURO.0223-18.2018. 
      eCollection 2018 Jul-Aug.