PMID- 30105830
OWN - NLM
STAT- MEDLINE
DCOM- 20191010
LR  - 20191010
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 119
IP  - 11
DP  - 2018 Nov
TI  - Study on the relationship between insulin growth factor 1 and liver fibrosis in 
      patients with chronic hepatitis C with type 2 diabetes mellitus.
PG  - 9513-9518
LID - 10.1002/jcb.27267 [doi]
AB  - OBJECTIVE: To investigate the correlation between serum protein level of insulin 
      growth factor 1 (IGF-1) and the degree of liver fibrosis in patients with chronic 
      hepatitis C (CHC) combined with type 2 diabetes mellitus (T2DM). METHODS: The 
      cases are divided into four groups. Then serum levels of IFG-1, alanine 
      aminotransferase (ALT), aspartate aminotransferase (AST), hepatitis C virus (HCV) 
      RNA, and HCV genotypes were detected simultaneously in patients with hepatitis C, 
      liver stiffness measurement (LSM) was measured by transient elastography, and 
      aspartate aminotransferase platelet ratio (APRI) score was determined. RESULTS: 
      There was no significant difference between CHC with T2DM group and CHC group in 
      diabetes family history (P > 0.05), but the difference between the two groups 
      were significantly lower than that of T2DM group ( P < 0.05). The levels of 
      fasting insulin and homeostatic model assessment of insulin resistance (HOMA-IR) 
      in CHC group with T2DM group were significantly higher than those in the other 
      two groups ( P < 0.05), while the IGF-1 RNA and the serum protein level in the 
      two groups were significantly lower than those in the CHC group, and were lower 
      than those in the control group ( P < 0.05). The level of serum IGF-1 was 
      negatively correlated with HOMA-IR, LSM, and APRI score in CHC with T2DM group ( 
      r = -0.71, -0.75, and -0.69; P < 0.01). CONCLUSION: The degree of hepatic 
      fibrosis in patients with CHC combined with T2DM was higher than that in non-T2DM 
      patients with CHC, which was mainly related to insulin resistance (IR) induced by 
      1b genotype HCV infection. IR can lead to impaired synthesis of IGF-1, and the 
      degree of damage has a corresponding relationship with hepatic fibrosis.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Cao, Li-Hua
AU  - Cao LH
AD  - Liver Disease Center, The Third Hospital of Qinhuangdao City, Qinhuangdao, China.
FAU - Lu, Feng-Min
AU  - Lu FM
AD  - Department of Microbiology and Infectious Disease Center, Peking University 
      Health Science Center, Beijing, China.
FAU - Lu, Xiao-Jie
AU  - Lu XJ
AUID- ORCID: 0000-0001-5167-3772
AD  - Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Zhu, Li-Yao
AU  - Zhu LY
AD  - Department of Hepatology, The Fourth People's Hospital of Huai'an, Huai'an, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20180813
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Insulin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alanine Transaminase/metabolism
MH  - Aspartate Aminotransferases/metabolism
MH  - Diabetes Mellitus, Type 2/*blood/*metabolism
MH  - Elasticity Imaging Techniques
MH  - Female
MH  - Genotype
MH  - Hepatitis C, Chronic/*blood/*metabolism
MH  - Humans
MH  - Insulin/blood/metabolism
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Lipid Metabolism/physiology
MH  - Liver Cirrhosis/metabolism
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - chronic hepatitis C
OT  - insulin growth factor 1
OT  - insulin resistance
OT  - liver fibrosis
OT  - type 2 diabetes mellitus
EDAT- 2018/08/15 06:00
MHDA- 2019/10/11 06:00
CRDT- 2018/08/15 06:00
PHST- 2018/01/28 00:00 [received]
PHST- 2018/06/22 00:00 [accepted]
PHST- 2018/08/15 06:00 [pubmed]
PHST- 2019/10/11 06:00 [medline]
PHST- 2018/08/15 06:00 [entrez]
AID - 10.1002/jcb.27267 [doi]
PST - ppublish
SO  - J Cell Biochem. 2018 Nov;119(11):9513-9518. doi: 10.1002/jcb.27267. Epub 2018 Aug 
      13.